王建華，男,，博士，教授,，博士生導師

廣州黃埔杰出人才

中科院“百人計劃”

中科院特聘教授

中國科學院大學客座教授

E-mail：jh_[email protected]

教育經(jīng)歷：

1995.09—1999.07  河南大學???????   生物學        

1999.09—2005.07??中國科學院昆明動物研究所  病毒學  

工作經(jīng)歷：

2005.09—2009.03??美國威斯康星州醫(yī)學院????????  博士后

2009.03—2020.03??中國科學院上海巴斯德研究所?????  研究員

2020.03—2025.02??中國科學院廣州生物醫(yī)藥與健康研究院   研究員

2025.03—至今 ?? 抗病毒性傳染病創(chuàng)新藥物全國重點實驗室  教授  

研究領域與興趣：

聚焦病毒性傳染病關鍵科學問題,，開展病毒致病機制、干預靶點發(fā)現(xiàn)和創(chuàng)新藥物研發(fā),。包括,，針對艾滋病病毒（HIV）潛伏根治缺乏治療靶點這一科學難題，闡述HIV潛伏維持和重激活的宿主動態(tài)調(diào)控機制,，鑒定起關鍵調(diào)控作用的宿主因子和細胞信號通路,，為HIV潛伏根治提供潛在靶點;針對重要傳染病病原,，建立成藥性評價體系，開展抗病毒創(chuàng)新藥物研發(fā),。

近年來主持的主要科研項目：

1.國家自然科學基金面上,，82172242, 從新型冠狀病毒誘導肥大細胞脫顆粒揭示炎癥反應產(chǎn)生的細胞學機制及免疫調(diào)節(jié)劑的研發(fā)，2022/01-2025/12,，直接經(jīng)費55萬,，主持

2.呼吸疾病國家重點實驗室開放課題，SKLRD-OP-2022207, 新冠狀病毒通過誘導肥大細胞脫顆粒增強肺微血管通透性的細胞學機制,，2022/01-2024/12,， 20萬，聯(lián)合主持

3.廣東省自然科學基金面上項目,，2022A1515012053,，從新冠病毒誘導肥大細胞脫顆粒炎癥揭示病毒誘導肺損傷的細胞免疫學機制，2022/01-2024/12,，10萬,，主持

4.中國科學院前沿科學重點研究項目，QYZDB-SSW-SMC059,，艾滋病病毒潛伏感染機制及治療策略研究,，2017/5-2022/12，250萬,，主持,；

5.國家自然科學基金面上，81873965,，HIV潛伏感染人源化小鼠模型的建立及在潛伏激活劑功能評價中的應用,，2019/01-2022/12，直接經(jīng)費80萬,，主持

6.科技部艾滋病和病毒性肝炎重大傳染病專項,，2018ZX10301101，HIV病毒潛伏庫清除新策略研究,。2018/01-2020/12, 183.74萬,，參與；

7.中國科學院科研裝備研制項目, 細胞三維超分辨實時顯微成像系統(tǒng), 2017/01-2018/12, 聯(lián)合申請,，承擔70萬（項目共298萬）,；

8.中國科學院分子病毒與免疫重點實驗室開放基金，人內(nèi)源性逆轉(zhuǎn)錄病毒的免疫應答,， 2017/01-2017/12,，6萬，聯(lián)合主持；

9.國家自然科學基金-NIH聯(lián)合項目,，81561128009,，HIV-1 Nef蛋白與宿主蛋白Naf1相互作用調(diào)控病毒潛伏感染, 2016/01-2018/12，直接經(jīng)費250萬, 主持,；

10.國家自然科學基金面上,，81572001，宿主因子Tollip抑制HIV-1轉(zhuǎn)錄及調(diào)控病毒潛伏感染的分子機制研究,，2016/01-2019/12，直接經(jīng)費50萬, 主持,；

11.科技部艾滋病和病毒性肝炎重大傳染病專項,，2014ZX10001003-003，宿主因子靶向敲除與造血干細胞遺傳改造平臺的建立,，2014/01- 2016/12,，139萬，子課題負責人,；

12.中科院交叉創(chuàng)新團隊人才基金,，利用機器人化三維拾取技術監(jiān)測病毒對宿主細胞的感染， 2013/01-2015/12,，100萬,，已結(jié)題，首席,；

13.國家重點基礎研究發(fā)展計劃（973計劃）,，2012CB519004，重要病毒持續(xù)性感染形成和維持的分子機制研究,，2012/1-2016/12,，70萬，已結(jié)題,，子課題參與,；

14.國家自然科學基金面上項目，81171567,，真菌誘導樹突狀細胞的激活增強其介導HIV-1感染T細胞的機制研究,，2012/01-2015/12，58萬,，已結(jié)題,，主持；

15.中科院病毒免疫重點實驗室開放基金,，2012-2014,，5萬，已結(jié)題，共同主持,；

16.上海市啟明星計劃項目,，11QA1407700，從HIV對TLR信號通路的挾持或利用分析樹突狀細胞介導病毒感染的分子機制,，2011/1-2013/12,，15萬，結(jié)題,，主持,；

17.中科院優(yōu)秀青年人才項目，KSCX2-EW-Q-2, 真菌刺激樹突狀細胞的免疫激活與HIV-1的致病機理研究,，2011/1-2013/12,，80萬，結(jié)題,，主持,；

18.中國科學院百人計劃項目，KSCX2-KW-BR-1,，HIV-1與樹突狀細胞的相互作用及病毒的致病機理,，2010/01-2012/12，200萬,，結(jié)題,，主持；

19.上海市自然科學基金面上項目,，10ZR1435200, MHC-Ⅱ分子在DC介導HIV-1感染T細胞中的作用研究, 2010/04-2012/03,10萬,，已結(jié)題，主持,。

20.病毒學國家重點實驗室開放基金,，2010011，樹突狀細胞介導HIV-1感染T細胞的分子機制,，2010/3-2011/2,，3萬，已結(jié)題,，共同主持,；

21.中科院疫苗網(wǎng)絡項目，KSCX2-YW-R-210,，基于樹突狀細胞的HIV-VLP疫苗的免疫策略,，2009-2010，30萬,，已結(jié)題,，子課題負責人,；

22.中科院上海生命科學研究院優(yōu)秀青年人才項目，2009KIP209,，樹突狀細胞介導HIV感染CD4+T細胞的分子機制,，2009-2011，21萬,，結(jié)題,，主持。

獲得榮譽：

2023,，《Journal of Leukocyte Biology》,Editor (2023-2025)

2022, 《Frontiers in Cellular and Infection Microbiology》,Associated Editor

2021, 廣州黃埔杰出人才

2020,，《生命的化學》雜志編委（2020.6-2024.5）

2018, 《Virology Journal》， Section Editor;

2017,，《Virologica Sinica》雜志編委,；

2016，上海市科技系統(tǒng)青年五四獎章,；

2015，中國科學院大學崗位教授,；

2013,，中科院“朱李月華優(yōu)秀教師獎”；

2011,，上海市啟明星計劃（A 類）,；

2010，賽諾菲-安萬特-中國科學院上海生命科學研究院優(yōu)秀青年人才獎,；

2010,，中科院“百人計劃”。

代表性論文：

1. Shuang Zhang, Chu-Lan Xu, Jing-Jing Wang, Xiao-Li Xiong, Jian-Hua Wang*. Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca²⁺ intracellular signaling cascade. J Virol. 2025, Accepted.

2. Tian-Jiao Fan, Chengzuo Xie, Xia Jin, Jie Cui, Jian-Hua Wang. HIV-1 Nef activates proviral DNA transcription via recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function. J Virol. 2025, Accepted.

3. Chengzuo Xie, Xia Jin, Wan-Wei Li*, Jian-Hua Wang*. Host factor Naf1 restricts HIV-1 infection of myeloid cells and compromises the capacity of dendritic cell to prime CD4⁺ T cell. Virol Sin. 2025, online.

4. Wu ML, Xie C, Li X, Sun J, Zhao J, Wang JH. Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia. Front Cell Infect Microbiol. 2024. PMCID: 38638822.

5. Cao JB, Zhu ST, Huang XS, Wang XY, Wu ML, Li X, Liu FL, Chen L, Zheng YT, Wang JH. Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury. Virol Sin. 2024. PMID: 38458399.

6. Hou J, Peng Y, Liu B, Zhang Q, Wang JH, Yu W, Chang J. 4'-Ethynyl-2'-deoxy-2'-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection. J Med Chem. 2023. PMID: 37535016.

7. Huang X, Fan W, Sun J, Yang J, Zhang Y, Wang Q, Li P, Zhang Y, Zhang S, Li H, Wang J, Feng L, Zhao J, Chen L, Qu L. SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril. Antiviral Res. 2023. PMID: 37207821.

8. Jia J, Zhao Y, Wang JH, Kuang YQ. Isolating peripheral blood mononuclear cells from HIV-infected patients for single-cell RNA sequencing and integration analysis. STAR Protoc. 2023. PMID: 37060557.

9. Song S, Lin Z, Zhao C, Wen J, Chen J, Xie S, Qi H, Wang J, Su X. Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia. Virol Sin. 2023. PMID: 37172825.

10. Qin J, Hu B, Song Q, Wang R, Zhang X, Yu Y, Wang JH. The transmembrane replacement H7N9-VLP vaccine displays high levels of protection in mice. Front Microbiol. 2022. PMID: 36274725.

11. Jia J, Zhao Y, Yang JQ, Lu DF, Zhang XL, Mao JH, Wang KH, Wang JH, Kuang YQ. Na?ve B cells with low differentiation improve the immune reconstitution of HIV-infected patients. iScience. 2022. PMID: 36465118

12. Han J, Zhou YH, Ma Y, Zhu G, Zhang D, Zhu B, Cheng T, Wang L, Wang JH, Li L, Zhang C. A New HIV-1 K28E32-Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men. Microbiol Spectr. 2022. PMID: 36214682.

13. Wu ML, Liu FL, Sun J, Li X, Qin JR, Yan QH, Jin X, Chen XW, Zheng YT*, Zhao JC*, Wang JH*. Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice. Zoological Research. 2022.  PMID: 35503561

14. Song ST, Wu ML, Zhang HJ, Su X*, Wang JH*. Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection. Front. Microbiol. 2022. PMID: 35197951.

15. Wen J, Li X, Zhao QX, Yang XF, Wu ML, Yan Q, Chang J, Wang H, Jin X, Su X, Deng K, Chen L, Wang JH*. Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 + T cells. Emerg Microbe Infect. 2022. PMID: 34985411.

16. Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi H, Wang J, Su X. Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. Cell Insight. 2022. PMID: 37193048.

17. Yu Y, Wan Z, Wang JH, Yang X, Zhang C. Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication. Virulence. 2022. PMID: 35132924.

18. Shi X, Yang Y, Zhang X, Chang X, Chen J, Wang C, Wang A, Wang J, Qin J, Ye X, Jin W, Zhang G. miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7. Viruses. 2022. PMID: 35062330.

19. Dong Y, Wan Z, Li S, Wang JH, Jin X, Yu G, Zhang C. Genomic phylogenetic analyses of four major hand, foot and mouth disease-related enteroviruses. Acta Virol. 2022. PMID: 35380863.

20. Wu ML, Liu FL, Sun J, Li X, He XY, Zheng HY, Zhou YH, Yan Q, Chen L, Yu GY, Chang J, Jin X, Zhao J, Chen XW*, Zheng YT*, Wang JH*. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury. Sig Transduct Target Ther. 2021. PMID: 34921131

21. Li T, Yang Y, Li Y, Wang Z, Ma F, Luo R, Xu X, Zhou G, Wang J, Niu J, Lv G, Crispe IN, Tu Z. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein. J Clin Invest, 2021. PMID: 34964720

22. Yan Q, Li P, Ye X, Huang X, Feng B, Ji T, Chen Z, Li F, Zhang Y, Luo K, Chen F, Mo X, Wang J, Feng L, Hu F, Lei C, Qu L, Chen L. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. J Immunol. 2021. PMID: 33846224.

23. Sun L, Peng Y, Yu W, Zhang Y, Liang L, Song C, Hou J, Qiao Y, Wang Q, Chen J, Wu M, Zhang D, Li E, Han Z, Zhao Q, Jin X, Zhang B, Huang Z, Chai J*, Wang JH*, Chang J*. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J. Med. Chem. 2020. PMID: 32678592

24. Lyu T, Yue Y, Hsieh E, Han Y, Zhu T, Song X, Cao W, Lyu W, Wang J, Li T. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC Infect Dis, 2020, PMID: 31964364

25. Zuo L, Liu K, Liu H, Hu Y, Zhang Z, Qin J, Xu Q, Peng K, Jin X, Wang JH, Zhang C. Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017). EClinicalMedicine. 2020, PMID: 31922125.

26. Ma L, Jiang QA, Sun L, Yang X, Huang H, Jin X, Zhang C, Wang JH*. X-linked RNA-binding Motif Protein modulates HIV-1 infection of CD4⁺ T cells by maintaining the tri-methylation of histone H3 lysine 9 at the downstream region of the 5′ long terminal repeat of HIV proviral DNA. mBio, 2020, PMID: 32317327.

27. Xie L, Chen L, Zhong C, Yu T, Ju Z, Wang M, Xiong H, Zeng Y, Wang J, Hu H, Hou W, Feng Y. MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6. Retrovirology. 2020. PMID: 32600399.

28. Fan TJ, Sun L, Yang XG, Jin X, Sun WW*, Wang JH*. The Establishment of an in vivo HIV-1 Infection Model in Humanized B-NSG Mice. Virolocia Sinica, 2019.  PMID: 31863357.

29. Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X*, Wang JH*. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway to Promote HIV-1 Infection and Reactivation. mBio, 2019. PMID:31848275.

30. Qu D, Sun WW, Li L, Ma L, Sun L, Jin X, Li T*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, PMID: 30788509.

31. Li Y, Fu X, Ma J, Zhang J, Hu Y, Dong W, Wan Z, Li Q, Kuang YQ, Lan K, Jin X, Wang JH*, Zhang C*. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nat Commun, 2019, PMID:31123265

32. Sun WW, Jiao S, Sun L, Zhou Z, Jin X, Wang JH*.SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin. mBio, 2018.PMID: 29717016.

33. Ma L, Sun L, Jin X, Xiong SD, Wang JH*.Scaffold attachment factor B suppresses HIV-1 infection of CD4⁺ cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat.J Bio. Chem. 2018.  PMID: 29887524.

34. Ren XX, Ma L, Sun WW, Kuang WD, Li TS, Jin X, Wang JH*.Dendritic cells maturated by co-culturing with HIV-1 latently infected Jurkat T cells or stimulating with AIDS-associated pathogens secrete TNF-alpha to reactivate HIV-1 from latency.Virulence, 2017. PMID: 28762683

35. Kuang WD, Zhou YH, Zhong P, Zhang C, Wang JH*. Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4. J Med Virol. 2017. PMID: 28500742.

36. Li C, Wang HB, Kuang WD, Ren XX, Song ST, Zhu HZ, Li Q, Xu LR, Guo HJ, Wu L*, Wang JH*. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4⁺ T cells. J Virol. 2016, PMID:27795436.

37. Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB*, Wang JH*.Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells.J Virol. 2015.PMID:26719250

38. Jiang AP, Jiang JF, Guo MG, Jin YM, Li YY, Wang JH*. Human blood circulating basophils capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26018157,；

39. Ren XX, Wang HB, Li C, Jiang JF, Xiong SD, Jin X, Wu L, Wang JH*. HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA.J Bio. Chem. 2016.PMID:26733199

40. Qian YW, Li C, Jiang AP, Ge S, Gu P, Fan X, Li TS, Jin X, Wang JH*, Wang ZL*. HIV-1 gp120 glycoprotein interacting with dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) down-regulates tight junction proteins to disrupt the blood retinal barrier and increase its permeability. J Bio. Chem. 2016.  PMID: 27605665.

41. Shen CJ, Jia YH, Tian RR, Ding M, Zhang C, Wang JH*. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J, 2012;PMID 22835829.

42. Ren XX, Li C, Xiong SD, Huang Z, Wang JH*, Wang HB*. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. Virulence. 2015. PMID: 26399965.

43. Zhang Y, Li SK, Yi Yang K, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J*, Kwok-Wing Tsui S*. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Sci Rep. 2015. 5:10806. PMID:26039376

44. Yang FC, Kuang WD, Li C, Sun WW, Qu D, Wang JH*. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLoS ONE, 2015; PMID:25915421

45. Ma L, Shen CJ, Cohen E, Xiong SD, Wang JH*. MiRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. PLoS ONE, 2014; PMID: 24932481.

46. Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF*, Wang JH*. Histamine enhances HIV-1-induced modulation of dendritic cells to skew na?ve T cell differentiation toward regulatory T cells. Virology, 2013; PMID 23652320.

47. Liu W, Qin Y, Bai L, Lan K, Wang JH*. Kaposi's-sarcoma -associated-herpesvirus -activated dendritic cells promote HIV-1 trans-infection and suppress CD4⁺ T cell proliferation. Virology, 2013; PMID23510674.

48. Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K*, Wang JH*. Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4⁺ T cells. PLoS One. 2011; PMID 22110688.

49. Qin Y, Li Y Y, Jiang A P, Jiang J F, Wang JH*. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection. Biochem Biophys Res Commun; 2012; PMID 22704932.

50. Tian RR, Guo HX, Wei JF, Yang CK, He SH*, Wang JH*. IFN-lambda inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. Antiviral Res. 2012; PMID: 22584351.

51. Ji H, Jiang Z, Lu P, Ma L, Li C, Pan H, Fu Z, Qu X, Wang P, Deng J, Yang X, Wang J, Zhu H.Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter.Mol Ther. 2016. PMID:26775808

52. Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res, 2013; PMID: 23804764.

53. Ren XX, Ma L, Liu QW, Li C, Huang Z, Wu L, Xiong SD, Wang JH, Wang HB.The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection. Virol J. 2014; PMID:24620896.

54. St Gelais C, Coleman CM, Wang JH, Wu L. HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation. PLoS One. 2012; PMID: 22479639.

55. Zhang C, de Silva S, Wang JH, Wu L. Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One. 2012; PMID: 22574228.

56. Li S K, Leung R K, Guo H X, Wei J F, Wang JH, Kwong K T, Lee S S, Zhang C, and Tsui S K. Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults. Clin Microbiol Infect. 2012,；PMID: 22084916.

57. Liu J, Chen K, Wang JH, and Zhang C. Molecular evolution of the primate antiviral restriction factor tetherin. PLoS One. 2010; PMID:20689591.

58. Guo D, Ding N, Xu Y, Guo H, Wei J F, Wang JH, He G, Yang R, and Zhang C.  Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: evidence of two independent introductions from Fujian. AIDS Res Hum Retroviruses, 2009; PMID:19534629.

59. Wang JH, Kwas C, Wu L. Intercellular adhesion molecules (ICAM)-1, but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission. J. Virol. 2009;PMID: 19211748.

60. Wang JH, Wells C, Wu L. Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ T cells. Virology, 2008; PMID: 18804253.

61. Janas AM, Dong C, Wang JH, Wu L. Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry. Virology, 2008; PMID: 18329684.

62. Dong C, Janas AM, Wang JH, Olson WJ, Wu L. Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection. J. Virol.2007; PMID: 17686876.

63. Wang JH, Janas AM, Olson WJ, Wu L. Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells. J. Virol. 2007; PMID: 17567699.

64. Wang JH, Janas AM, Olson WJ, KewalRamani VN, Wu L. CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. J. Virol. 2007; PMID: 17151103.

65. Wang JH, Kong J, Li W, Molchanova V, Chikalovets I, Belogortseva N, Luk'yanov P, Zheng YT. A beta-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2006; PMID:16316787.

66. Wang JH, Tam SC, Huang H, Ouyang DY, Wang YY, and Zheng YT. Site-directed PEGylation of richosanthin retained its anti-HIV activity with reduced potency in vitro. Biochem. Biophys. Res. Commun. 2004; PMID:15094363.

67. Wang JH., Nie HL, Huang H, Tam SC, and Zheng YT. Independency of anti-HIV-1 activity from ribosome-inactivating activity of trichosanthin. Biochem. Biophys. Res. Commun. 2003; PMID:12593852.

68. Wang JH, Nie HL, Tam SC, Huang H, and Zheng YT. Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett. 2002; PMID: 12417329.