朱博，男,，博士,，副教授，博士生導(dǎo)師
博士后創(chuàng)新人才支持計(jì)劃獲得者
河南省優(yōu)秀青年科學(xué)基金獲得者
河南省青年拔尖人才（D類）
河南省藥學(xué)會(huì)副理事長(zhǎng)
E-mail：[email protected],；[email protected]
教育經(jīng)歷：
2005.09—2009.07 河南大學(xué) 藥學(xué)院
2009.09—2012.07 河南大學(xué) 藥學(xué)院
2013.09—2016.7 河南大學(xué) 化學(xué)化工學(xué)院
工作經(jīng)歷：
2012.08—2013.08 漯河醫(yī)學(xué)高等?？茖W(xué)校??藥學(xué)系
2017.04—2022.10 河南師范大學(xué) 化學(xué)化工學(xué)院
2022.10—2023.04 河南師范大學(xué) 省部共建國(guó)家重點(diǎn)實(shí)驗(yàn)室（籌）
2023.04—至今 河南師范大學(xué) 抗病毒性傳染病創(chuàng)新藥物全國(guó)重點(diǎn)實(shí)驗(yàn)室
主講課程：
本科：《有機(jī)化學(xué)實(shí)驗(yàn)》、《現(xiàn)代化學(xué)進(jìn)展》
研究生：《藥物合成中的元素化學(xué)》
研究領(lǐng)域與興趣：
1. 核苷類,、莨菪堿類活性分子的合成,、優(yōu)化及其活性研究
2. 抗腫瘤藥物設(shè)計(jì)合成與活性研究
近年來主持的主要科研項(xiàng)目：
1.國(guó)家自然科學(xué)基金指南引導(dǎo)類原創(chuàng)探索計(jì)劃項(xiàng)目子課題（82151525），主持
2.河南省自然科學(xué)基金-優(yōu)秀青年基金（212300410051）,，主持
3.國(guó)家自然科學(xué)基金青年基金（81903465）,，主持
4.博士后創(chuàng)新人才支持計(jì)劃（BX201700071），主持
5.博士后面上基金（2017M622348）,，主持
獲獎(jiǎng)情況：
新鄉(xiāng)市文明教師
新鄉(xiāng)市抗擊新冠肺炎疫情先進(jìn)個(gè)人
河南師范大學(xué)立德樹人先進(jìn)個(gè)人
河南師范大學(xué)急難險(xiǎn)重先進(jìn)個(gè)人
代表性論文：
(23) Shan, M.; Yu,Y.; Sun, M.; Yang, S.; Wang, M.; Zhu, B.*; Chang, J.* Bifunctional Organocatalyst-Catalyzed Dynamic Kinetic Resolution of Hemiketals for Synthesis of Chiral Ketals via Hydrogen Bonding Control. Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2024.109781.
(22) Mao, H.; Zhang, Y.; Cao, H.; Shi, Q.*; Lan,Y.; Chang, J.*; Zhu, Bo.* Thiourea as a precatalyst for the electron donor–acceptor complex photoactivation platform of oxime esters. Organic Chemistry Frontiers,2024, 11, 3204–3213.
(21) Wang, L.; Zhu, X.; Wang, B.; Wang, Y.; Wang, M.; Yang, S.; Su, C.; Chang, J.*; Zhu, B.* Design, Synthesis, and Activity Evaluation of Fluorine-Containing Scopolamine Analogues as Potential Antidepressants. J. Med. Chem., 2024, 67, 5391–5420. (Front cover picture)
(20) Wang, M.; Li, L.; Yang, S.; Guo, F.; Zhu, G.*; Zhu, B.*; Chang, J.* Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation. Bioorg. Chem., 2023, 135, 106505.
(19) Zhu, B.*; Zhang, T.; Yu, Y.; Pan, D.; Mao, H.; Zhu, G.; Chang, J.* Synthesis of γ-hydroxy-γ-perfluoroalkyl butenolides and exocyclic double bond butanolides via regioselective allylic alkylations of MBH carbonates with 2-perfluoroalkyl-oxazol-5(2H)-ones. Organic Chemistry Frontiers,2022, 9, 2955-2962.
(18) Zhu, B.*; Sun, H.; Fan, H.; Wang, M.; Guo, F.; Zhai, Y.; Zhu M.; Chang, J.*Asymmetric Br?nsted base-catalyzed aza-Michael addition and [3 + 2] cycloaddition reactions of N-ester acylhydrazones and enones. Organic Chemistry Frontiers, 2022, 9, 6631-6639.
(17) Zhu, B.*, Fan, H., Ding, Y., Zhai, Y., Wang, L., Wang, M., Zhu, G., Chang, J.* Copper(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-ester acylhydrazones an β-trifluoromethyl-α,β-unsaturated ketones. Organic Chemistry Frontiers, 2022, 9, 5544-5550.
(16) Zhu, B.*; Yang, T.; Gu, Y.; Zhu, S.; Zhu, G.; Chang, J*. Enantioselective organocatalytic amination of 2-perfluoroalkyl-oxazol-5(2H)-ones towards the synthesis of chiral N,O-aminals with perfluoroalkyl and amino groups. Organic Chemistry Frontiers, 2021, 8, 4160-4165.
(15) Zhang, J.; Li, Y.; Wang, L.; Liu, H.; Lu, S.; Liu, Y.; Li, K.; Liu, B.; Li, S.; Shao, F.; Wang, K.; Shen, M.; Li, R.; Cui, J.; Sun, P.; Ma, C.; Zhu, B.; Wang, Z.; Wan, Y.; Yu, S.; Che, Y.; Wang, C.; Wang, C.; Zhang, Q.; Zhao, L.; Peng, X.*; Cheng, Z.; Chang*, J.*; Jiang, J*. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduction and Targeted Therapy, 2021, 6, 414.
(14) 李路瑤,，徐鑫堯，朱博??,，?？?biāo)??吡唑酮化合物在催化不對(duì)稱反應(yīng)中的應(yīng)用. 化學(xué)進(jìn)展, 2020, 32, 1710-1728.
(13) Li, L.; Yang, T.; Zhang, T.; Zhu, B.*; Chang, J.* Organocatalytic Asymmetric Tandem Cyclization/Michael Addition via Oxazol-5(2H)-One Formation: Access to Perfluoroalkyl-Containing N,O-Acetal Derivatives. J. Org. Chem. 2020, 85, 12294-12303.
(12) Li, L.; Zhu, B.*; Fan, H.; Jiang, Z.; Chang, J.* Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles. Organic Chemistry Frontiers2020, 7, 1343–1348.
(11) Xu, X.; He, Y.; Zhou, J.; Li, X.; Zhu, B.*; Chang, J.* Organocatalytic Asymmetric Michael Addition of Pyrazol-5-ones to β?Trifluoromethyl-α,β-unsaturated Ketones: Stereocontrolled Construction of Vicinal Quaternary and Tertiary Stereocenters. J. Org. Chem. 2020, 85, 574?584.
(10) Lu, B.; Xin, S.; Zhu, B.*; Chang, J.* Enantioselective Conjugate Addition–Protonation of 5H-Oxazol-4-ones and 5-Methylene 1,3-oxazolidine-2,4-diones: 2,2'-Biphenol-Induced Diastereoselectivity Switch. Chin. J. Chem. 2019, 37, 689-694.
(9) Zhu, B.; Lu, B.; Zhang, H.; Xu, X.; Jiang, Z.*; Chang, J.* Phase-Transfer-Catalyzed, Enantioselective Vinylogous Conjugate Addition?Cyclization of Olefinic Azlactones To Access Multifunctionalized Chiral Cyclohexenones. Org. Lett.2019, 21, 3271-3275.
(8) Xia, X.; Zhu, Q.; Wang, J.; Chen, J.; Cao, W.; Zhu, B.*; Wu, X.* Direct Asymmetric Vinylogous Mannich Addition of 3,5-Disubstituted-4-nitroisoxazoles to Isatin-Derived Imines Catalyzed by a Bifunctional Phase-Transfer-Catalyst. J. Org. Chem. 2018, 83, 14617–14625.
(7) Zhu, B.; Li, F.; Lu, B.; Chang, J.*; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of 5-Alkyl-4-Nitroisoxazoles to Paraformaldehyde. J. Org. Chem.2018, 83, 11350–11358.
(6) Zhu, B.; Lee, R.; Yin, Y.; Li, F.; Coote, M.*; Jiang, Z.* Enantioselective Vinylogous Amination of 5-Alkyl-4-nitroisoxazoles with a Dipeptide-Based Guanidinium Phase-Transfer Catalyst. Org. Lett. 2018, 20, 429?432.
(5) Li, S.; Zhu, B.(共一); Lee, R.; Qiao, B.; Jiang, Z.* Visible light-induced selective aerobic oxidative transposition of vinyl halides using a tetrahalogenoferrate(III) complex catalyst. Organic Chemistry Frontiers.2018, 5, 380?385.
(4) Zhu, B.; Qiu, S.; Li, J.; Coote, M. L.; Lee, R.; Jiang, Z.* Asymmetric [4+2] annulation of 5H-thiazol-4-ones with a chiral dipeptide-based Br?nsted base catalyst. Chem. Sci.2016, 7, 6060–6067.
(3) Zhu, B.; Lee, R.; Li, J.; Ye, X.; Hong, S.-N.; Qiu, S.; Coote, M. L.; Jiang, Z.* Chemoselective Switch in Asymmetric Organocatalysis of 5H-oxazol-4-ones and N-Itaconimides towards Tandem Conjugate Addition?Protonation or [4+2] Cycloaddition. Angew. Chem. Int. Ed.2016, 55, 1299?1303.
(2) Zhu, B.; Zhang, W.; Lee, R.; Han, Z.; Yang, W.; Tan, D.; Huang, K.-W.; Jiang, Z.* Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3-Hydroxy-2-Oxindole Derivatives. Angew. Chem. Int. Ed. 2013, 52, 6666–6670 (Inside back cover picture) (Highlighted by Synfacts 2013, 9, 0784–0784; Contributors: Benjamin List, Mattia Riccardo Monaco).
(1) Zhu, B.; Yan, L.; Pan, Y.; Lee, R.; Liu, H.; Han, Z.; Huang, K.-W.; Tan. C.-H.; Jiang, Z. Lewis Base Catalyzed Enantioselective Allylic Hydroxylation of Morita-Baylis-Hillman Carbonates with Water. J. Org. Chem. 2011, 76, 6894–6900.