呂楠,，男,，博士,，講師
E-mail：[email protected]
教育經(jīng)歷：
2020-2024 廈門大學(xué) 理學(xué)博士
2017-2020 廣東藥科大學(xué)/中山大學(xué)（聯(lián)合培養(yǎng)） 醫(yī)學(xué)碩士
2010-2014 廣東藥科大學(xué) 理學(xué)學(xué)士
工作經(jīng)歷：
2014-2017 華蘭生物股份有限公司 疫苗研發(fā)部 研發(fā)員
2024-至今 河南師范大學(xué) 抗病毒性傳染病創(chuàng)新藥物全國(guó)重點(diǎn)實(shí)驗(yàn)室 講師
研究領(lǐng)域與興趣：
理論與計(jì)算化學(xué)生物學(xué),、計(jì)算機(jī)輔助藥物設(shè)計(jì)、生物信息學(xué)
主要研究蛋白-蛋白,，蛋白-藥物相互作機(jī)制、藥物篩選與設(shè)計(jì),、分子動(dòng)力學(xué)相關(guān)的算法開發(fā),，機(jī)器學(xué)習(xí)等
代表性論文：
(1)Lv, N.; Cao, Z. Subpocket-Based Analysis Approach for the Protein Pocket Dynamics. J. Chem. Theory Comput.2024, 20 (11), 4909–4920.
(2)Jiao, Q.; Ye, H.; Lv, N.; Huang, M.; Wu, R.; Yang, T.; Cao, Z.; Lei, Q.; Fang, W.; Xie, H. How the Strength of Proteins Interactions Affects the Phase Behavior of Protein Complexes. Food Hydrocoll.2024, 149, 109654. (Co-first)
(3)Liu, C.; Lv, N.; Song, Y.; Dong, L.; Huang, M.; Shen, Q.; Ren, G.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. Interaction Mechanism between Zein and β-Lactoglobulin: Insights from Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2023, 135, 108226. (Co-first)
(4)Liu, C.; Lv, N.; Xu, Y.-Q.; Tong, H.; Sun, Y.; Huang, M.; Ren, G.; Shen, Q.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. pH-Dependent Interaction Mechanisms between β-Lactoglobulin and EGCG: Insights from Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2022, 133, 108022. (Co-first)
(5)Lv, N.; Cao, Z. RBD Spatial Orientation of the Spike Protein and Its Binding to ACE2: Insight into the High Infectivity of the SARS-CoV-2 Delta Variant from MD Simulations. Phys. Chem. Chem. Phys.2022, 24 (39), 24155–24165.
(6)Liu, C.; Lv, N.; Ren, G.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. Explore the Interaction Mechanism between Zein and EGCG Using Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2021, 120, 106906. (Co-first)
(7)Wang, K.; Lyu, N.; Diao, H.; Jin, S.; Zeng, T.; Zhou, Y.; Wu, R. GM-DockZn: A Geometry Matching-Based Docking Algorithm for Zinc Proteins. Bioinformatics2020, 36 (13), 4004–4011. (Co-first)
(8)Lyu, N.; Wang, K.; Zhang, F.; Qin, H.; Zhao, Y.; Wu, R.; Si, Y.; Wang, L. Recognition of PDL1/L2 by Different Induced-Fit Mechanisms of PD1: A Comparative Study of Molecular Dynamics Simulations. Phys. Chem. Chem. Phys.2020, 22 (3), 1276–1287.