個(gè)人簡(jiǎn)介：馬春華，男，博士，講師，中國(guó)化學(xué)會(huì)會(huì)員。E-mail: [email protected]
教育經(jīng)歷：
2004.09-2008.06 山東大學(xué)藥學(xué)院，藥學(xué)專(zhuān)業(yè)，理學(xué)學(xué)士；
2008.09-2013.12 山東大學(xué)藥學(xué)院，藥物化學(xué)專(zhuān)業(yè)，理學(xué)博士；
工作經(jīng)歷：
2013.12-2015.12，復(fù)旦大學(xué)藥學(xué)院，藥物化學(xué)專(zhuān)業(yè)，博士后；
2016.03-至今，河南師范大學(xué)化學(xué)化工學(xué)院講師。
研究領(lǐng)域與興趣：
1、小分子抗腫瘤藥物的設(shè)計(jì)合成
2、基于靶點(diǎn)的先導(dǎo)化合物的設(shè)計(jì)和結(jié)構(gòu)優(yōu)化
近年來(lái)主持的主要科研項(xiàng)目:
1、國(guó)家自然科學(xué)基金青年基金：基于腺嘌呤替代物的雙底物SAHH抑制劑的設(shè)計(jì)、合成及活性研究，項(xiàng)目批準(zhǔn)號(hào)：82003585, 2021.01-2023. 12, 24.00萬(wàn)元
2、河南省自然科學(xué)基金：小分子神經(jīng)生長(zhǎng)因子模擬物的設(shè)計(jì)、合成及作用機(jī)制研究，項(xiàng)目編號(hào)：162300410182, 2017.1-2018.12, 10萬(wàn)元
3、河南省高等學(xué)校重點(diǎn)科研項(xiàng)目基礎(chǔ)研究計(jì)劃：小分子NGF模擬物的設(shè)計(jì)、合成及應(yīng)用研究，項(xiàng)目編號(hào)：17A350008, 2017.1-2018.12，3萬(wàn)元
4、高端外國(guó)專(zhuān)家項(xiàng)目：I類(lèi)新藥布魯頓酪氨酸激酶抑制劑（BTK inhibitor HB040）的研究與開(kāi)發(fā)，項(xiàng)目編號(hào)：GDW20186300346, 30萬(wàn)元
5、企業(yè)橫向：新型BTK抑制劑的研究與開(kāi)發(fā)，合同編號(hào)：XH2019059，50萬(wàn)元
代表性論文：
12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors. Journal of Medicinal Chemistry, 2021, https://doi.org/10.1021/acs.jmedchem.1c01559.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2021, DOI: 10.1016/S1872-2067(21)63917-7
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724.
9）Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers, 2021, 8, 3286-3291.
8）Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.
6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides, Organic Letter 2019, 21(17), 7179-7183.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
獲得榮譽(yù)與獎(jiǎng)勵(lì)：
河南師范大學(xué)優(yōu)秀教師
Individual profile：Chunhua Ma，Male，Ph D，lecturer，Membership of China Chemical Society.E-mail: [email protected]
Education experience：
2004.09-2008.06 School of pharmaceutical sciences Shandong University, Pharmacology, Bachelor of Science;
2008.09-2013.12 School of pharmaceutical sciences Shandong University,Medicinal chemistry, Doctor of Medicine.
Work experience：
2013.12-2015.12, School of Pharmacy Fudan University, Medicinal chemistry, Post doctor;
2016.03-until now, School of Chemistry and Chemical Engineering, Henan Normal University, Lecturer.
Research Interest：
1、The design and synthesis of small molecular compounds with antitumor activity
2、Target-based design and structure optimization of lead compounds
近年來(lái)主持的主要科研項(xiàng)目:
1、Henan Natural Science Foundation：The design, synthesis and mechanism of small molecular never growth factor mimics, Project number：162300410182, 2017.1-2018.12, 0.1Million
2、Basic Research Plan of Key Scientific Research Projects in Henan Higher Education Institutions：The design, synthesis and application of small molecular never growth factor mimics, Project number：17A350008, 2017.1-2018.12，0.03 Million
3、High-end Foreign Expert Project：Research and Development of Bruton Tyrosine Kinase Inhibitor (BTK inhibitor HB040), Project number：GDW20186300346，3 Million
代表性論文：
12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors. Journal of Medicinal Chemistry, 2021, https://doi.org/10.1021/acs.jmedchem.1c01559.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2021, DOI: 10.1016/S1872-2067(21)63917-7
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724.
9）Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers, 2021, DOI: 10.1039/D1QO00064K.
8）Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.
6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides, Organic Letter 2019, 21(17), 7179-7183.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
獲得榮譽(yù)與獎(jiǎng)勵(lì)：
Excellent Teachers of Henan Normal University
