姜玉欽，河南鎮(zhèn)平人。博士，教授，藥物化學(xué)、生物與醫(yī)藥碩士生導(dǎo)師，教務(wù)處副處長。E-mail: [email protected]。
河南省科技創(chuàng)新杰出青年
河南省教育廳學(xué)術(shù)技術(shù)帶頭人
河南省手性醇類藥物工程技術(shù)研究中心主任
化學(xué)制藥及生物醫(yī)用材料河南省工程實驗室主任
河南省藥學(xué)會藥物化學(xué)專業(yè)委員會常委
九三學(xué)社新鄉(xiāng)市第八屆監(jiān)督委員會委員
教育經(jīng)歷：
1998.09-2002.07 河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院，精細化工專業(yè)，工學(xué)學(xué)士，指導(dǎo)教師 婁向東教授；
2002.09-2005.07 河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院，應(yīng)用化學(xué)專業(yè)，工學(xué)碩士，導(dǎo)師 李偉教授；
2005.09-2008.12 南開大學(xué)高分子化學(xué)研究所，高分子化學(xué)與物理專業(yè)，理學(xué)博士，導(dǎo)師 陳永勝教授。
工作經(jīng)歷：
2009.01-2010.12 鄭州大學(xué)化學(xué)系，分析化學(xué)博士后，合作導(dǎo)師 屈凌波教授；
2011.01-2015.03 河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院，講師，碩士生導(dǎo)師；
2015.04-2021.4 河南師范大學(xué)化學(xué)化工學(xué)院，副教授, 教授；
2020.11至今 河南師范大學(xué)教務(wù)處，副處長。
講授課程：
《藥物分析》《化學(xué)制藥工藝學(xué)》《藥物分析及制藥檢測常用技術(shù)》
研究領(lǐng)域與興趣：
1、抗腫瘤創(chuàng)新藥物
2、藥物合成工藝
3、有機反應(yīng)方法學(xué)
4、高分子生物醫(yī)用材料
近年來主持的主要科研項目:
1、河南省科技創(chuàng)新杰出青年人才支持計劃：高品質(zhì)曲克蘆丁原料藥合成關(guān)鍵技術(shù)及產(chǎn)業(yè)化研究，2017.01-2018.12，30萬元。
2、河南省產(chǎn)學(xué)研項目：維腦路通原料藥生產(chǎn)新工藝及產(chǎn)業(yè)化研究，2015.01-2016.12，25萬元。
3、橫向項目：曲克蘆丁化學(xué)合成新工藝，2014.05-2016.12，50萬元。
4、橫向項目：阿托伐他汀鈣原料藥新工藝研究，2017.11-2021.12，100萬元。
5、橫向項目：抗腫瘤新藥的研究與開發(fā)，2019.01-2022.01，100萬元。
6、橫向項目：抗過敏藥物工藝開發(fā)及DMF文件制作，2019.10-2021.02，150萬元。
7、河南省高等教育教學(xué)改革研究與實踐重點項目：生物與醫(yī)藥碩士創(chuàng)新及聯(lián)合培養(yǎng)基地建設(shè)研究與實踐，2019-2021，3萬元。
8、河南省專業(yè)學(xué)位研究生精品教學(xué)案例項目：制藥工藝與技術(shù)，2021-2022，3萬元。
近年來發(fā)表論文：
22. Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-amino-1h-imidazole-5-carboxamide derivatives as highly selective, covalent Bruton’s Tyrosine Kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2021, DOI:10.1021/acs.jmedchem.1c01559.
21、Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2021, DOI: 10.1016/S1872-2067(21)63917-7.
20、Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724(1-23).
19、Chunhua Ma, Ming Chen, Zhiwen Feng, Yan Zhang, Jin Wang, Yuqin Jiang*, and Bing Yu*. Functionalization of imidazo[1,2-a]pyridines via radical reactions. New Journal of Chemistry, 2021, 45, 9302-9314.
18、Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li, Yuqin Jiang* and Bing Yu*. Photocatalytic transition-metal-free direct 3-alkylation of 2-aryl-2h-indazoles in dimethyl carbonate, Organic Chemistry Frontiers, 2021, 8, 3286-3291.
17、Yusang Xia, Ling Yan, Guojiang Mao, Wenli Jiang, Wenxin Wang, Yongfei Li, Yuqin Jiang*, and Chunyan Li*. A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish, Sensors and Actuators B: Chemical, 2021, 340, 129920 (1-7).
16、Yuqin Jiang, Pengfei Li, Jie Zhao, Bingxian Liu*, and Xingwei Li*. Iodonium ylides as carbene precursors in Rh(III)-catalyzed C-H activation, Organic Letters, 2020, 22(19), 7475-7479.
15、Yuqin Jiang, Lu Jiang, Yuanyuan Pang, Dan Kai, Xiaoshan Fan*, and Zibiao Li*. Surface migration of fluorinated-siloxane copolymer with unusual liquid crystal behavior for highly efficient oil/water separation, ACS Applied Polymer Materials, 2020, 2, 3612-3620.
14、Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
13、Yuqin Jiang, Pengfei Li, Juanjuan Wang, Jie Zhao, Yang Li, Yawen Zhang, Junbiao Chang*, Bingxian Liu* and Xingwei Li*. Rh(III)-catalyzed coupling of acrylic acids and ynenones via ole?nic C-H activation and Michael addition, Organic Letters, 2020, 22(2), 438-442.
12、Yuqin Jiang, Yanyan Li, Tingting Yang, Xin Shi*, Huajun Suo, Weiwei Zhang* Guiqing Xu and Wei Li*. Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3-triazole moiety, Journal of the Chinese Chemical Society, 2020, 67(1), 165-171.
11、TingtingYang, Xin Shi, Libing Guo, Shaohua Gu, Weiwei Zhang, Guiqing Xu, Wei Li* and Yuqin Jiang*. Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties, Journal of Chemical Research, 2019, 43(7-8), 241-247.
10、Yuqin Jiang, Kai Wu, Qian Zhang,* Keqing Li, Yanyan Li, Pengyang Xin, Weiwei Zhang and Haiming Guo*. A dual-responsive hyperbranched supramolecular polymer constructed by cooperative host-guest recognition and hydrogen-bond interactions, Chemical Communications, 2018, 54, 13821-13824.
9、Yuqin Jiang, Kai Wu, Liming Fan, Jinglin Zhao, Yuqing Yang, Weiwei Zhang* and Guiqing Xu*. Cu(OAc)2H2O/NH2OH·HCl/CH3COONa: A facile and efficient catalyst system for copper-catalyzed azide-alkyne click reactions in water, Journal of the Chinese Chemical Society, 2018, 65, 505-510.
8、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang, Guiqing Xu. An efficient NaHSO3-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water, Chemical Papers, 2018, 72, 1265-1276.
7、Yuqin Jiang, Huajun Suo, Yaru Zhao, Xiyong Li, Yamin Sun, Xingfeng Li, Wenpei Dong, Wei Li, Weiwei Zhang* and Guiqing Xu. DBU-promoted Cu(OAc)2·H2O-catalysed coupling reactions of aryl iodides and sodium azide, Journal of Chemical Research, 2018, 42, 247-250.
6、Yuqin Jiang, Kai Wu, Xuxia Tan, Dandan Zhang, Wenpei Dong, Wei Li, Guiqing Xu and Weiwei Zhang*. [bmim]PF6/KOH: a recyclable catalytic system for an azide-arylacetaldehyde [3+2] cycloaddition, Journal of Chemical Research, 2017, 41, 631-635.
5、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang* and Guiqing Xu*. Design, synthesis, and antifungal evaluation of novel benzoxazole derivatives containing a 1,2,3-triazole moiety, Journal of the Chinese Chemical Society, 2017, 64, 1197-1202.
4、Yuqin Jiang,* Xingfeng Li, Yaru Zhao, Shuhong Jia, Mingrui Li, Zhiqi Zhao, Ruili Zhang, Wei Li and Weiwei Zhang*. An efficient CuI/DBU-catalyzed one-pot protocol for synthesis of 1,4-disubstituted 1,2,3-triazoles, RSC Advances, 2016, 6, 110102-110107.
3、Yuqin Jiang,* Xing He, Weiwei Zhang, Xingfeng Li, Niu Guo, Yaru Zhao, Guiqing Xu* and Wei Li. Metallic copper wire: a simple, clear and reusable catalyst for the CuAAC reaction in supercritical carbon dioxide, RSC Advances, 2015, 5, 73340-73345.
2、Weiwei Zhang, Baoqi Ren, Yuqin Jiang* and Zhiguo Hu*. Carboxymethylpullulan promoted Cu2O-catalyzed Huisgen-click reaction, RSC Advances, 2015, 5, 12043-12047.
1、Weiwei Zhang, Xing He, Baoqi Ren, Yuqin Jiang* and Zhiguo Hu*. Cu(OAc)2·H2O-an efficient catalyst for Huisgen-click reaction in supercritical carbon dioxide, Tetrahedron Letters, 2015, 56, 2472-2475.
授權(quán)專利：
7、姜玉欽 等，一種阿托伐他汀鈣中間體ATS-9的純化方法，ZL 201811169986.X，2020年。
6、姜玉欽 等，一種高純度福多司坦的制備方法，ZL 201810560947.6，2020年。
5、姜玉欽 等，一種高含量曲克蘆丁的制備方法，ZL 201710119984.9，2020年。
4、姜玉欽 等，一種奈拉西坦的制備方法，ZL 201410766319.5，2017年。
3、姜玉欽 等，一種采用自吸式攪拌高壓釜制備曲克蘆丁的方法，ZL 201410766698.8，2017年。
2、姜玉欽 等，具有抑菌活性的烯唑醇-1,2,3-三氮唑類化合物及其制備方法，ZL 201410184618.8，2016年。
1、姜玉欽 等，一種沙坦聯(lián)苯的制備方法，ZL 201310383875.X，2015年。
科技獎勵：
2、曲克蘆丁合成關(guān)鍵技術(shù)創(chuàng)新及產(chǎn)業(yè)化，河南省教育廳科技成果獎一等獎，第一完成人，2020年。
1、阿托伐他汀鈣關(guān)鍵技術(shù)研究與產(chǎn)業(yè)化，河南省科學(xué)技術(shù)進步獎叁等獎，第四完成人，2014年。
個人榮譽：
獲河南省抗擊新冠肺炎疫情先進個人；河南省科技創(chuàng)新杰出青年；河南省優(yōu)秀碩士學(xué)位論文指導(dǎo)教師；河南省高校科技管理工作先進工作者；河南省高等學(xué)校優(yōu)秀共產(chǎn)黨員；新鄉(xiāng)市九三學(xué)社抗擊新冠肺炎疫情先進個人暨社會服務(wù)先進個人；中國“互聯(lián)網(wǎng)+”大學(xué)生創(chuàng)新創(chuàng)業(yè)大賽全國銅獎指導(dǎo)教師；河南師范大學(xué)首屆“盧錦梭師德楷模獎教金”獲得者、“急難險重先進個人”“青年五四獎?wù)隆薄皟?yōu)秀教師”“三育人先進個人”“研究生優(yōu)秀指導(dǎo)教師”等。
Individual Profile: Yuqin Jiang, PhD, associate professor, School of Chemistry and Chemical Engineering, Henan Normal University. E-mail: [email protected].
Education:
1998.09-2002.06 School of Chemistry and Environmental Sciences, Henan Normal University, Bachelor of Engineering;
2002.09-2005.06 School of Chemistry and Environmental Sciences, Henan Normal University, Master of Engineering;
2005.09-2008.12 Institute of Polymer Chemistry, Nankai University, Doctor of Science.
Professional Experience:
2011.01, School of Chemistry and Environmental Sciences, Henan Normal University;
2015.04, School of Chemistry and Chemical Engineering, Henan Normal University, associate professor;
2009.01-2011.01, Department Chemistry, Zhengzhou University, analytical chemistry postgraduate.
Research Interests:
1、Anti-tumor Drug Design and Synthesis
2、Pharmaceutical Technology
3、Methodology of Organic Synthesis
4、Functional Polymer Materials
Research Support:
1、Innovative Talents Program of Henan Province (No. 174100510025): Research on the key technology and industrialization of high-purity bulk drug troxerutin, Role: PI, 2017.1-2018.12, ￥300K.
2、Research on the new technology and industrialization of drug Venoruton, Role: PI, 2015.1-2016.12,￥250K.
3、New synthetic process for troxerutin, Role: PI, 2014.5-2016.12, ￥500K.
4、New synthetic process for atorvastatin calcium, Role: PI, 2017.11-2021.12, ￥1000K.
5、Anti-tumor drug design and synthesis, Role: PI, 2019.01-2022.01, ￥1000K.
6、New synthetic process for antiallergic agent, Role: PI, 2019.10-2021.02, ￥1500K.
7 、Postgraduate Education Reform Project of Henan Province, Role: PI, 2019-2021, ￥30K.
Representative Publications:
22. Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-amino-1h-imidazole-5-carboxamide derivatives as highly selective, covalent Bruton’s Tyrosine Kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2021, DOI:10.1021/acs.jmedchem.1c01559.
21、Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2021, DOI: 10.1016/S1872-2067(21)63917-7.
20、Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724(1-23).
19、Chunhua Ma, Ming Chen, Zhiwen Feng, Yan Zhang, Jin Wang, Yuqin Jiang*, and Bing Yu*. Functionalization of imidazo[1,2-a]pyridines via radical reactions. New Journal of Chemistry, 2021, 45, 9302-9314.
18、Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li, Yuqin Jiang* and Bing Yu*. Photocatalytic transition-metal-free direct 3-alkylation of 2-aryl-2h-indazoles in dimethyl carbonate, Organic Chemistry Frontiers, 2021, 2021, 8, 3286-3291.
17、Yusang Xia, Ling Yan, Guojiang Mao, Wenli Jiang, Wenxin Wang, Yongfei Li, Yuqin Jiang*, and Chunyan Li*. A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish, Sensors and Actuators B: Chemical, 2021, 340, 129920 (1-7).
16、Yuqin Jiang, Pengfei Li, Jie Zhao, Bingxian Liu,* and Xingwei Li*. Iodonium ylides as carbene precursors in Rh(III)-catalyzed C-H Activation, Organic Letters, 2020, 22(19), 7475-7479.
15、Yuqin Jiang, Lu Jiang, Yuanyuan Pang, Dan Kai, Xiaoshan Fan*, and Zibiao Li*. Surface migration of fluorinated-siloxane copolymer with unusual liquid crystal behavior for highly efficient oil/water separation, ACS Applied Polymer Materials, 2020, 2, 3612-3620.
14、Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
13、Yuqin Jiang, Pengfei Li, Juanjuan Wang, Jie Zhao, Yang Li, Yawen Zhang, Junbiao Chang*, Bingxian Liu* and Xingwei Li*. Rh(III)-catalyzed coupling of acrylic acids and ynenones via ole?nic C-H activation and Michael addition, Organic Letters, 2020, 22(2), 438-442.
12、Yuqin Jiang, Yanyan Li, Tingting Yang, Xin Shi*, Huajun Suo, Weiwei Zhang* Guiqing Xu and Wei Li*. Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3-triazole moiety, Journal of the Chinese Chemical Society, 2020, 67(1), 165-171.
11、TingtingYang, Xin Shi, Libing Guo, Shaohua Gu, Weiwei Zhang, Guiqing Xu, Wei Li* and Yuqin Jiang*. Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties, Journal of Chemical Research, 2019, 43(7-8), 241-247.
10、Yuqin Jiang, Kai Wu, Qian Zhang,* Keqing Li, Yanyan Li, Pengyang Xin, Weiwei Zhang and Haiming Guo*. A dual-responsive hyperbranched supramolecular polymer constructed by cooperative host-guest recognition and hydrogen-bond interactions, Chemical Communications, 2018, 54, 13821-13824.
9、Yuqin Jiang, Kai Wu, Liming Fan, Jinglin Zhao, Yuqing Yang, Weiwei Zhang* and Guiqing Xu*. Cu(OAc)2H2O/NH2OH·HCl/CH3COONa: A facile and efficient catalyst system for copper-catalyzed azide-alkyne click reactions in water, Journal of the Chinese Chemical Society, 2018, 65, 505-510.
8、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang, Guiqing Xu. An efficient NaHSO3-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water, Chemical Papers, 2018, 72, 1265-1276.
7、Yuqin Jiang, Huajun Suo, Yaru Zhao, Xiyong Li, Yamin Sun, Xingfeng Li, Wenpei Dong, Wei Li, Weiwei Zhang* and Guiqing Xu. DBU-promoted Cu(OAc)2·H2O-catalysed coupling reactions of aryl iodides and sodium azide, Journal of Chemical Research, 2018, 42, 247-250.
6、Yuqin Jiang, Kai Wu, Xuxia Tan, Dandan Zhang, Wenpei Dong, Wei Li, Guiqing Xu and Weiwei Zhang*. [bmim]PF6/KOH: a recyclable catalytic system for an azide-arylacetaldehyde [3+2] cycloaddition, Journal of Chemical Research, 2017, 41, 631-635.
5、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang* and Guiqing Xu*. Design, synthesis, and antifungal evaluation of novel benzoxazole derivatives containing a 1,2,3-triazole moiety, Journal of the Chinese Chemical Society, 2017, 64, 1197-1202.
4、Yuqin Jiang,* Xingfeng Li, Yaru Zhao, Shuhong Jia, Mingrui Li, Zhiqi Zhao, Ruili Zhang, Wei Li and Weiwei Zhang*. An efficient CuI/DBU-catalyzed one-pot protocol for synthesis of 1,4-disubstituted 1,2,3-triazoles, RSC Advances, 2016, 6, 110102-110107.
3、Yuqin Jiang,* Xing He, Weiwei Zhang, Xingfeng Li, Niu Guo, Yaru Zhao, Guiqing Xu* and Wei Li. Metallic copper wire: a simple, clear and reusable catalyst for the CuAAC reaction in supercritical carbon dioxide, RSC Advances, 2015, 5, 73340-73345.
2、Weiwei Zhang, Baoqi Ren, Yuqin Jiang* and Zhiguo Hu*. Carboxymethylpullulan promoted Cu2O-catalyzed Huisgen-click reaction, RSC Advances, 2015, 5, 12043-12047.
1、Weiwei Zhang, Xing He, Baoqi Ren, Yuqin Jiang* and Zhiguo Hu*. Cu(OAc)2·H2O-an efficient catalyst for Huisgen-click reaction in supercritical carbon dioxide, Tetrahedron Letters, 2015, 56, 2472-2475.
