團(tuán)隊(duì)負(fù)責(zé)人

余國營教授,，博士生導(dǎo)師，中科院百人計(jì)劃,，俄羅斯自然科學(xué)院院士,、河南師范大學(xué)生命科學(xué)學(xué)院院長(zhǎng)、卓越人才特聘教授,，國家肺纖維化生物學(xué)過程及防控學(xué)科創(chuàng)新引智基地（111計(jì)劃）主任,，河南省-科技部共建細(xì)胞分化調(diào)控國家重點(diǎn)實(shí)驗(yàn)室培育基地主任，中國細(xì)胞生物學(xué)學(xué)會(huì)理事,，河南省呼吸學(xué)科學(xué)術(shù)帶頭人,。從事呼吸疾?。ㄌ匕l(fā)性肺纖維化、急性肺損傷和新冠肺炎等）的分子機(jī)制和藥物研發(fā)研究,，重點(diǎn)關(guān)注肺泡上皮細(xì)胞損傷及其所營造微環(huán)境的改變,，靶向上皮細(xì)胞損傷修復(fù)過程，提出了“甲狀腺激素緩解肺部損傷應(yīng)激”理論,，發(fā)現(xiàn)甲狀腺激素的第四大功能,。在國際上首次報(bào)道了甲狀腺素能夠顯著抑制肺纖維化進(jìn)展，研發(fā)的靶向藥物GC-1已完成II期臨床試驗(yàn),。小分子藥物(MRG201)開發(fā)取得明顯成效,，正在進(jìn)行臨床前試驗(yàn)。在Nature Medicine,、PNAS,、AJRCCM、EMBO 等國際頂刊發(fā)表論文120 余篇,，主持國家重點(diǎn)研發(fā)計(jì)劃,、科技部新冠防控專項(xiàng)，獲得美國專利授權(quán)11項(xiàng),，中國專利受權(quán)1項(xiàng),。曾獲得中國科協(xié)青年科學(xué)家獎(jiǎng)、國際肺及肺泡纖維化組織青年科學(xué)家,，肺纖維化基金會(huì)Albert科學(xué)家成就獎(jiǎng),。

一、團(tuán)隊(duì)成員

團(tuán)隊(duì)現(xiàn)有骨干成員8名,，其中,，教授1人，副教授2人,，博士5人（博士后2人）,。近年來團(tuán)隊(duì)發(fā)展迅速，以團(tuán)隊(duì)帶頭人為核心,，已匯聚形成了一支學(xué)歷層次高,、年齡結(jié)構(gòu)、知識(shí)結(jié)構(gòu)合理,、密切協(xié)作的科研創(chuàng)新團(tuán)隊(duì),。

二、研究平臺(tái)

團(tuán)隊(duì)依托河南師范大學(xué)（一）國家肺纖維化生物學(xué)過程及防控學(xué)科創(chuàng)新引智基地(111計(jì)劃),、 （二）平原實(shí)驗(yàn)室、 （三） 河南省-科技部共建細(xì)胞分化調(diào)控國家重點(diǎn)實(shí)驗(yàn)室培育基地,、 （四）河南省生物工程研究應(yīng)用中心,、（五）河南省生物工程重點(diǎn)實(shí)驗(yàn)室,、（六）河南省生物工程制藥工程實(shí)驗(yàn)室、（七）河南省肺纖維化國際聯(lián)合實(shí)驗(yàn)室,、 （八）河南省纖維化生物學(xué)杰出外籍科學(xué)家工作室,、（九）河南師范大學(xué)生物醫(yī)學(xué)研究院，在肺纖維化細(xì)胞分化調(diào)控的分子生物學(xué)過程與機(jī)理研究,、肺纖維化生物標(biāo)志物的篩選與應(yīng)用,、靶向藥物研發(fā)等領(lǐng)域開展研究，取得了一系列創(chuàng)新性成果,。

三,、研究方向及成果

（一）亞裔肺纖維化遺傳與環(huán)境易感性研究

（二）肺纖維化細(xì)胞分化調(diào)控的分子生物學(xué)過程與機(jī)理研究

（三）肺纖維化生物標(biāo)志物的篩選與應(yīng)用

（四）靶向藥物研發(fā) 

四、科研成果

（一）發(fā)表國際學(xué)術(shù)論文 (2018-2023)：

1. Lan Wang; Zhongzheng Li; Ruyan Wan; Xin Pan; Bin Li; Huabin Zhao; Juntang Yang; Weiming Zhao; Shenghui Wang; Qiwen Wang; Peishuo Yan; Chi Ma; Hongmei Yuan; Ivan Rosas; Chen Ding; Baofa Sun; Guoying Yu*; Single-Cell RNA-seq Provides New Insights into Therapeutic Roles of Thyroid Hormone in the Idiopathic Pulmonary Fibrosis, Am J Respir Cell Mol Biol, 2023

2. Lan Wang; Minghui Zhu; Yan Li; Peishuo Yan; Zhongzheng Li; Xiuping Chen; Juntang Yang; Xin Pan; Huabin Zhao; Shenghui Wang; Hongmei Yuan; Mengxia Zhao; Xiaogang Sun; Ruyan Wan; Fei Li; Xiaobo Wang; Hongtao Yu; Ivan Rosas; Chen Ding; Guoying Yu*; Serum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis, Molecular & Cellular Proteomics, 2023, 22(4):100524

3. Weiming Zhao; Lan Wang; Juntang Yang; Xinyu Chen; Xiaoshu Guo; Kai Xu; Ningdan Wang; Wenyu Zhao; Cong Xia; Hui Lian; Ivan Rosas; Guoying Yu*; Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration, Cell Communication and Signaling, 2023, 21(56): 1-17

4. Weiming Zhao; Lan Wang; Yaxuan Wang; Hongmei Yuan; Mengxia Zhao; Hui Lian; Shuaichen Ma; Kai Xu; Zhongzheng Li; Guoying Yu*; Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis, International Journal of Molecular Sciences, 2023, 24(10):8749

5. Juntang Yang; Chenxi Liang; Lulu Liu; Lan Wang; Guoying Yu*; High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters, Biomolecules, 2023, 13(3):558

6. Zhongzheng Li; Shenghui Wang; Huabin Zhao; Peishuo Yan; Hongmei Yuan; Mengxia Zhao; Ruyan Wan; Guoying Yu,，Lan Wang; Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports, 2023, 13(1): 1-15

7. Wang, G; Tong, J; Li, Y; Qiu, X; Chen, A; Chang, C; Yu, G. Overview of CircRNAs Roles and Mechanisms in Liver Fibrosis. Biomolecules 2023, 13, 940.

8. Gaiping Wang, Anqi Chen , Yu Wu , Danlin Wang , Cuifang Chang , Guoying Yu *. Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation. Cellular & Molecular Biology Letters. 2022,，27(1)：98.

9. Lan Wang; Wenyu Zhao; Cong Xia; Zhongzheng Li; Weiming Zhao; Kai Xu; Ningdan Wang; Hui Lian; Ivan O. Rosas; Guoying Yu ; TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF, International Journal of Molecular Sciences, 2022, 23(24):15705

10. Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan, Weiming Zhao, Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas and Guoying Yu*. Fenbendazole attenuates bleomycin-Induced pulmonary fibrosis in mice via suppression of fibroblast-to-myofibroblast differentiation. Int. J. Mol. Sci. 2022,23, 14088.

11. Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu*. Inhibition of MAD2L1 mediates pulmonary fibrosis through impairment of mitochondrial function and induction of cell senescence. 2022, Article ID 9663354, 13

12. Maurizio Chioccioli, Subhadeep Roy, Rachel Newell, Linda Pestano, Brent Dickinson, Kevin Rigby, Jose Herazo-Maya, Gisli Jenkins, Steward Ian, Gauri Saini, Simon R. Johnson, Rebecca Braybrooke, Guoying Yu, Maor Sauler, Farida Ahangari, Shuizi Ding, Joseph DeIuliis, Nachelle Aurelien, Rusty L. Montgomery, and Naftali Kaminski. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis. eBioMedicine 2022;85: 104304. https://doi.org/10.1016/j.ebiom.2022.104304

13. Chunyan Zhang, Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Quo, Bingyu Ye*, GuoYing Yu*. Overview of microRNAs as diagnostic and prognostic biomarkers for high-incidence cancers in 2021. International Journal of Molecular Sciences, 2022, 23(19): 11389.

14. Chunyan Zhang, Yabin Zhao, Qiwen Wang, Jianru Qin, Bingyu Ye, Cunshuan Xu*, GuoYing Yu*. Overexpression of miR-125a-5p inhibits hepatocyte proliferation through the STAT3 regulation in vivo and in vitro. International Journal of Molecular Sciences, 2022, 23: 8661

15. Bingyu Ye, Wenlong Shen, Chunyan Zhang, Mengli Yu, Xinru Ding, Man Yin, Yahao Wang, Xinjie Guo, Ge Bai, Kailin Lin, Shu Shi, Ping Li, Yan Zhang, Guoying Yu*, Zhihu Zhao*. The role of ZNF143 overexpression in rat liver cell proliferation. BMC Genomics, 2022, 23: 483.

16. Deming Li, Xiaoshu Guo, Wenyu Zhao , Jingyu Chen , Cong Xia , Guoying Yu*. Genome-wide DNA methylation dynamics in carbon tetrachloride-induced mice liver fibrosis Iran J Basic Med Sci 2023; 26: 85-92.

17. Chang C, Wang D, Xi L, Guo X, Wang G, Yu G*. The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells. Biochem Pharmacol. 2022 Aug;202:115117. doi: 10.1016/j.bcp.2022.115117. Epub 2022 Jun 6. PMID: 35671788

18. Wang Y, Gong W, Zhou H, Hu Y, Wang L, Shen Y, Yu Guoying, Cao J. A novel miRNA from egg-derived exosomes of Schistosoma japonicum promotes liver fibrosis in murine schistosomiasis. Front. Immunol., 27 April 2022| https://doi.org/10.3389/fimmu.2022.860807.

19. Dong Yajuan, Zhao Yongjuan, Li Shenwei, Wan Zhenzhou, Lu Renfei, Yang Xianguang, Yu Guoying, Reboud Julien, Cooper Jonathan M, Tian Zhengan, Zhang Chiyu*. Multiplex, variant-tolerant, real-time RT-LAMP for SARS-CoV-2 detection using HFman probe. ACS Sensors, 2022. 25;7(3):730-739. DOI: 10.1021/acssensors.1c02079

20. Dong Y, Wan Zhengzhou, Li Shenwei, Wang Jian-Hua, Jin Xia, Yu Guoying*, Zhang Chiyu*. Genomic phylogenetic analyses of four major Hand, Foot and Mouth Disease-related Enteroviruses. Acta virologica. 2022. 66(1):27-38. DOI: 10.4149/av_2022_104

21. Zhang Y, Yu Guoying, Kaminski N, Lee PJ.PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury. AJP Lung Cellular and Molecular Physiology, 320(2), 2021 DOI: 10.1152/ajplung.00598.2020

22. Wu MengLi, Liu FengLiang, Sun Jing, Li Xin, He Xiaoyan, Zheng Hongyi ,Zhou Yanheng, Qin Qihong, Chen Ling, Yu Guoying, Chang Junbiao, Jin Xia, Zhao Jincun, Chen Xinwen, Yong Tangzheng and Wang Jian-Hua*. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury. Signal transduction and targeted therapy, 2021.Dec.17;6(1), 1-15. https://doi.org/10.1038/s41392-021-00849-0.

23. Dong Y, Wu X, Li S, Lu R, Li Y, Wan Z, Qin J, Yu Guoying, Jin X, Zhang C.Comparative evaluation of 19 reverse transcription loop-mediated isothermal amplification assays for detection of SARS-CoV-2. Scientific Reports 11: 2936, 2021. DOI:10.1038/s41598-020-80314

24. Yang J, Pan X, Wang L, Yu Guoying*.Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis. Molecular medicine 2020, 26(1).

25. Zhang F, Yang B, Wang Y, Zhu J, Liu J, Yu Guoying, Qin J, Song W, Ding C.Time- and dose-resolved proteome of PM (2.5)-exposure-induced lung injury and repair in rats. J Proteome Res 2020 Aug 7;19(8):3162-3175.

26. Yang X, Chen X, Ding C, Bai Z, Zhu J, Sun G, Yu Guoying*.Epidemiological investigation and prevention control analysis of the longitudinal distribution of COVID-19 in Henan Province, China. mSphere 2020, 5(5).

27. Ye B, Yang G, Li Y, Zhang C, Wang Q, Yu Guoying*. ZNF143 in chromatin looping and gene regulation. Front Genet 2020, 11.

28. Nikos Xylourgidis, Kisuk Min, Farida Ahangari, Guoying Yu, Jose D. Herazo-Maya,Theodoros Karampitsakos, Vassilis Aidinis, Leonhard Binzenh?fer, Anton M. Bennett ,Naftali Kaminski, Argyrios Tzouvelekis. Role of mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis, Am J Physiol Lung Cell Mol Physiol. 2019 Sep 4. doi: 10.1152/ajplung.00264.2018

29. Yin L, Wang Y, Lin Y, Yu Guoying, Xia Q. Explorative analysis of the gene expression profile during liver regeneration of mouse: a microarray-based study. Artificial cells, nanomedicine, and biotechnology 2019, 47(1):1113-1121

30. Zhang C, Ye B, Wei J, Wang Q, Xu C, Yu Guoying*. MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/ CASPASE8/CASPASE3 signaling pathway. Atif Cells Nanomed Biotechnol. 2019;47(1):4110-4118

31.  Lan Wang，Ming Lu Xu,，Ling Xin,，Chi Ma，Guoying Yu. Oxidative stress induced apoptosis mediated anticancer activity of Rhus typhina fruits extract in human colon cancer. Medicinal Chemistry Research, 2019, (28), 6, 917–925

32. Wang Q, Ye B, Wang P, Yao F, Zhang C, Yu Guoying*. Overview of microRNA-199a regulation in Cancer. Cancer Management 2019; 11: 10327–10335

33. Yin L, Wang Y, Guo X, Xu C, Yu Guoying*. Comparison of gene expression in liver regeneration and hepatocellular carcinoma formation, Cancer Management and Research 2018:10 5691–5708

34. Wandi Zhu , Song Li , Chao Wang , Guoying Yu , Mark R Prausnitz , Bao-Zhong Wang. Enhanced immune responses conferring cross-protection by skin vaccination with a tri-component influenza vaccine using a microneedle patch. Front. Immunol. 9:1705. doi: 10.3389/fimmu.2018.01705

35. Zhu W, Li S, Wang C, Yu Guoying, Prausnitz MR, Wang BZ. Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination with a Tri-Component Influenza Vaccine Using a Microneedle Patch. Front Immunol. 2018 Jul 30;9:1705. doi: 10.3389/fimmu.2018.01705. PMID: 30105019; PMCID: PMC6077188.

36. Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu Guoying, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ. Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7758-E7767. doi: 10.1073/pnas.1805713115. Epub 2018 Jul 31. PMID: 30065113; PMCID: PMC6099848.

37. Zhang X, Jin Z, Shen M, Chang Z, Yu Guoying, Wang L, Xia X. Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish, Fish and Shellfish Immunology (2022), doi: https://doi.org/10.1016/j.fsi.2022.05.005 

38. Yuyuan Zhang , Mengguo Han , Xiaoxue Sun , Guojun Gao , Guoying Yu, Liong Huang, Ying Chen. EGCG Promotes Neurite Outgrowth through the Integrinβ1/FAK/p38 Signaling Pathway after Subarachnoid Hemorrhage. Evid Based Complement Alternat Med. 25;2021:8810414.  doi: 10.1155/2021/8810414.

39. Guoying Yu, Gabriel Iberra, Naftali Kaminksi. Fibrosis: Lessons from OMICS analyses of the human lung [J]. Matrix Biology 2018.68-69: 422-434

40. Guoying Yu; Tzouvelekis Argyris; Graham Morven; Liu Xinran; Homer Robert J.; Scanlan Thomas S.; Mannam Praveen; Lee Patty J.; Herzog Erica L.; Bianco Antonio C.; Kaminski Naftali ; Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function, Nature Medicine, 2018, 24(1): 39-49.

（二）中國專利：

1,、甲狀腺激素及其藥學(xué)上可接受的鹽或前藥在制備治療和/或預(yù)防皮膚疾病的藥物中的應(yīng)用,。授權(quán)公告號(hào)：CN 106983738 B

2、特發(fā)性肺纖維化疾病診斷標(biāo)志物及其制備診斷或預(yù)后工具中的應(yīng)用,。201911277110.1

3,、特發(fā)性肺纖維化疾病診斷標(biāo)志物CBR1及其制備診斷或預(yù)后工具中的應(yīng)用。 202011218094.1

4,、特發(fā)性肺纖維化疾病診斷標(biāo)志物CCT6A及其制備診斷或預(yù)后工具中的應(yīng)用,。202011218095.6

5、特發(fā)性肺纖維化血漿蛋白標(biāo)志物及其在制備檢測(cè)試劑或診斷工具中的應(yīng)用,。202210506078.5

（三）美國專利：

1,、Methods of Treating or Preventing Acute Respiratory Distress Syndrome. Pub.No: 20210008020

2、Compositions and Methods of Treating or Preventing Fibrotic Lung Diseases. Pub.No: 20200113863

（四）科研項(xiàng)目（2018-2023）：