常翠芳，1982年2月生,，畢業(yè)于新疆大學(xué),，博士、副教授,，碩士生導(dǎo)師,。2011年博士畢業(yè)后就職于河南師范大學(xué)生命科學(xué)學(xué)院，主要從事細(xì)胞生物學(xué)和分子生物學(xué)的教學(xué)和科研工作,。自工作以來(lái),，主持國(guó)家自然科學(xué)基金項(xiàng)目、河南省自然科學(xué)基金項(xiàng)目,、教育廳項(xiàng)目,、校級(jí)項(xiàng)目等，并參與完成多項(xiàng)國(guó)家級(jí)重大項(xiàng)目,，在J Cell Physiol,、Cell Biochem Funct等期刊發(fā)表論文50多篇，參編的《大鼠肝再生的功能基因組學(xué)研究》專著獲2010年教育部自然科學(xué)二等獎(jiǎng),。

目前主要講授本科生的《細(xì)胞生物學(xué)》,、《分子生物學(xué)》和研究生的《高通量分析生物學(xué)》、《生物技術(shù)制藥》,、《生物學(xué)教學(xué)技能》,、《中學(xué)生物活動(dòng)課設(shè)計(jì)與實(shí)踐》等課程,。

肝纖維化、肝再生的分子調(diào)控機(jī)理

中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)會(huì)員

河南省實(shí)驗(yàn)動(dòng)物學(xué)學(xué)會(huì)理事

1. 國(guó)家自然科學(xué)基金項(xiàng)目：絲氨酸蛋白酶抑制劑III對(duì)大鼠再生肝的肝細(xì)胞增殖調(diào)控機(jī)理研究,，主持

2. 河南省自然科學(xué)基金項(xiàng)目：絲氨酸蛋白酶抑制劑I和III調(diào)控再生肝的肝細(xì)胞機(jī)理研究,，主持

3. 河南省自然科學(xué)基金項(xiàng)目：肝再生相關(guān)孤兒受體GPR50調(diào)控肝細(xì)胞增殖的蛋白組學(xué)及其作用機(jī)制研究，主持

4. 河南省科技攻關(guān)項(xiàng)目：金銀花抗肝癌效應(yīng)物質(zhì)的篩選及應(yīng)用研究,，主持

5. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目：SPINK1調(diào)控大鼠正常肝細(xì)胞和肝癌細(xì)胞增殖機(jī)理的比較研究,，主持

6. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目：干擾SPINK1對(duì)肝纖維化的影響及調(diào)控機(jī)制研究，主持

7. 國(guó)家自然科學(xué)基金項(xiàng)目：一個(gè)大鼠肝再生相關(guān)的新lncRNA（rLALR1）調(diào)節(jié)肝細(xì)胞增殖的作用及機(jī)理研究,，參與

8. 國(guó)家973計(jì)劃前期研究專項(xiàng)：大鼠肝再生的蛋白質(zhì)學(xué)研究，參與

9. 國(guó)家973計(jì)劃前期研究專項(xiàng)：肝臟損傷修復(fù)與再生機(jī)制的蛋白質(zhì)組學(xué)基礎(chǔ)研究,，參與

代表性論文：

1. Zhao WM, Xi LL, Yu GY, Wang GP, Chang CF. High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro. J Cell Commun Signal.2023, 17(4):1435-1447. 

2. Chang CF, Wang DL, Xi LL, Guo XQ, Wang GP, Yu GY. The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells. Biochem Pharmacol. 2022, 202:115117.

3. Chang CF, Xie JJ, Yang QD, Yang J, Luo YR,  Xi LL, Guo JL, Yang GG, Jin W, Wang GP. Serine peptidase inhibitor Kazal type III (SPINK3) promotes BRL‐3A cell proliferation by targeting the PI3K–AKT signaling pathway. Journal of Cellular Physiology. 2020, 235(3): 2209-2219.

4. Li  JJ, Ye CL, Chang CF. Comparative  transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq. BMC  Plant Biol. 2020, 20(1):341.

5. Wang GP, Chu PP, Chen M, Cheng LY, Zhao CC, Chen SS, Li XF, Yang GG, Chang CF. Osteopontin promotes rat  hepatocyte proliferation both in vitro and in vivo. Artificial Cells, Nanomedicine and Biotechnology. 2019, 47(1): 3745-3757.

6. Wang GP; Guo XQ, Cheng LY, Chu PP, Chen M, Chen YH, Chang CF. An integrated analysis of the circRNA-miRNA-mRNA  network reveals novel insights into pot ential mechanisms of cell proliferation during liver regeneration, Artificial Cells, Nanomedicine and  Biotechnology. 2019, 47(1): 3873-3884.

7. Chang CF, Zhao WM, Luo YR, Xi LL, Chen SS, Zhao CC, Wang GP, Guo JL, Xu CS. Serine peptidase inhibitor Kazal type I (SPINK1) promotes BRL-3A cell proliferation via p38, ERK, and JNK pathways. Cell Biochem Funct. 2017, 35(6):339-348.

8. Chang CF, Niu ZP, Gu NN,  Zhao WM, Wang GP, Jia YF, Li DM, Xu CS. Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level. BMC Cell Biology, 2015, 16:25.

9. Chang CF, Xu CS. Transcriptome atlas of aromatic amino acid family metabolism-related genes in eight liver cell types uncovers the corresponding metabolic pathways in rat liver regeneration. Int J Biochem Cell Biol, 2010, 42(10):1708-1716.

10. Xu CS, Chang CF. Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration. Amino Acids. 2008, 34(1):91-102.

11. Chang CF, Yang J, Li XF, Zhao WM, Li Y, Guo PJ, Wang GP, Xu CS. Thrombopoietin signaling pathway regulates the hepatocytes activation in rat liver regeneration. Biochem  Genet, 2015, 53(9-10): 244-259.

12. Chang CF, Yang J, Li XF, Zhao WM, Chen SS, Wang GP, Xu CS. SPINK3: A novel growth factor that promotes rat liver regeneration. Molecular Biology, 2016, 50(3):398-404.

13. Chang CF, Zhao WM, Yang J, Li MH, Zhou Y, Xu CS. Study on activity of the signaling pathways regulating hepatocyte differentiation during rat liver regeneration. Anim Cells Syst, 2014, 18(6): 416-424.

14. Chang CF, Xu CS. Transcriptome atlas of glutamine family amino acid metabolism-related genes in eight regenerating liver cell types. Cell Biol Int, 2010, 34(12):1189-1198.

15. Chang CF, Fan JY, Zhang FC, Ma J, Xu CS. Transcriptome atlas of eight liver cell types uncovers effects of histidine catabolites on rat liver regeneration. J Genet, 2010, 89(4):425-436.

16. Chang CF, Yang J, Zhao WM, Li Y, Guo PJ, Li MH, Zhou Y, Xu CS. Gene expression profiling analysis of  5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells. Genet Mol Res, 2015, 14(2): 3409-3420.

17. Chang CF, Zhao WM, Mei JX, Zhou Y, Pan CY, Xu TT, Xu CS. Branches of NF-κb signaling pathway regulate  hepatocyte proliferation in rat liver regeneration. Genet Mol Res, 2015,14 (3):7643-7654.

18. Geng XF, Chang CF, Zang XY, Sun JY, Li PF, Guo JL, Xu CS. Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration. Gene, 2016, 575(2 Pt 1):224-232.

19. Ding Y, Chang CF, Niu ZP, Dai KQ, Geng  XF, Li DM, Guo JL, Xu CS. Overexpression of Transcription Factor Foxa2 and Hnf1α induced Rat Bone Mesenchymal Stem Cells into Hepatocyte. Cytotechnology, 2016, 68(5):2037-2047.

專利成果： 

1.基于OPN基因誘導(dǎo)的肝細(xì)胞體外增殖方法（專利號(hào): ZL201510773582.1）

2.一種表達(dá)人血清白蛋白的質(zhì)粒和重組菌以及它們的應(yīng)用(ZL 201310078906.0)

3.表達(dá)人血清白蛋白的質(zhì)粒和重組菌以及它們的應(yīng)用(ZL 201310078280.3)

4 一種抗癌藥物及其應(yīng)用（ZL 2018 10968867.4）