王蘭,，女,，教授,，博士生導(dǎo)師,。國家肺纖維化生物學(xué)過程及防控學(xué)科創(chuàng)新引智基地（111計劃）秘書,，河南省器官纖維化杰出外籍科學(xué)家工作室負(fù)責(zé)人，中國生物物理學(xué)會表型組分會委員,，河南省生物化學(xué)與分子生物學(xué)學(xué)會副理事長,，河南省藥學(xué)會中藥資源委員會委員，河南省藥學(xué)會天然產(chǎn)物委員會委員,，國際期刊《Fibrosis》副主編,。主要從事肺纖維化生物標(biāo)志物和甲狀腺激素調(diào)控肺纖維化的代謝穩(wěn)態(tài)研究。

2011年6月博士畢業(yè)于韓國江原大學(xué)醫(yī)生命學(xué)院,，獲得生物醫(yī)學(xué)博士學(xué)位,。2006.10－2007.10間，作為訪問學(xué)者到丹麥哥本哈根大學(xué)生命科學(xué)學(xué)院合作研究,，2016.7－2017.7 在美國華盛頓州立大學(xué)藥學(xué)院訪問學(xué)者,，主要從事端粒酶基因的表觀遺傳調(diào)控研究, 2017.12--2019.08，復(fù)旦大學(xué)生科院訪問研究,，主要從事多組學(xué)解析疾病機(jī)理研究,。目前主持及參與國家重點研發(fā)專項、國家自然基金,、河南省重點研發(fā)專項,、河南省國際科技合作項目、國家虛擬仿真實驗教學(xué)一流課程,、河南省優(yōu)質(zhì)資源課-雙語教學(xué)示范課等項目10余項,，在Naturecommunications, Advanced Science,Theranostics等國際期刊發(fā)表學(xué)術(shù)論文80余篇，發(fā)明授權(quán)國家專利3項,，受理5項,，主編《肺纖維化小鼠模型構(gòu)建，診斷及治療》,、參編《生物化學(xué)》等教材6部,。

多組學(xué)解析疾病機(jī)理

肺纖維化生物標(biāo)志物

甲狀腺激素調(diào)控肺纖維化的代謝穩(wěn)態(tài)

河南省生物化學(xué)與分子生物學(xué)學(xué)會副理事長

國際期刊《Fibrosis》副主編

中國生物物理學(xué)會表型組分會委員

河南省藥學(xué)會中藥資源委員會委員

河南省藥學(xué)會天然產(chǎn)物委員會委員

1、甲狀腺激素對肺纖維化的治療作用與機(jī)理研究,。國家重點研發(fā)計劃任務(wù)負(fù)責(zé)人

2,、基于S蛋白受體結(jié)合結(jié)構(gòu)域（RBD）的新冠肺炎病毒疫苗研發(fā)及肺纖維化控制。高端外國專家引進(jìn)計劃新冠肺炎防控專項計劃

3,、肺纖維化治療新藥研發(fā),。河南省重點研發(fā)計劃。第一參與人

4,、肺纖維化新藥GC-1研發(fā),。新鄉(xiāng)市重大科技創(chuàng)新專項,。第一參與人

5、器官纖維化杰出外籍科學(xué)家工作室,。河南省外國專家項目,。負(fù)責(zé)人

6、特發(fā)性肺纖維化診斷血清標(biāo)志物的確立,。河南省科技攻關(guān)項目,，主持

7、多組學(xué)解析甲狀腺激素調(diào)控肺纖維化的機(jī)制,。河南省國際科技合作,，主持

8、肺纖維化血清標(biāo)志物的研發(fā),。橫向合作,。主持

9、植物源性抗菌肽生物活性研究,。河南省重點科技攻關(guān)項目,。主持

10、火炬樹果實有效成分抑制結(jié)腸癌機(jī)理研究,。河南省科技攻關(guān)項目。主持

11,、肺纖維化小鼠模型構(gòu)建,、診斷及治療虛擬仿真實驗。國家級一流課程

12,、《高級生物化學(xué)》河南省優(yōu)質(zhì)資源課雙語教學(xué)示范課,，負(fù)責(zé)人

代表性論文：

1. Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Yanlin Zhou, Guoying Yu*, Lan Wang*. The Thyroid Hormone Analog GC-1Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. AdvancedScience. 2024 https:// doi.10.1002/advs.202401931

2. Xin Pan, Lan Wang*, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li,Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng li, Saiya Guo, Peishuo Yan, ChenDing, Ivan O. Rosas, Guoying Yu*. TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA. Nature Communication. 2024. DOI : 10.1038/s41467-024-52827-z

3. Bin Li, Jingyi Liu,Wanyu He, Yanlin Zhou, Man Zhao, Cong Xia, Xiaoyue Pan, Zhihua Ji, RuoyuDuan, Hui Lian, Kai Xu, Guoying Yu, Lan Wang*. Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury.Theranostics. 2025; 15(6): 2360-2374. doi: 10.7150/thno.101866.

4. Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, MiaomiaoZhu, Lan Wang* , Guoying Yu*.NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence. Respiratory Research (2024) 25:154.https://doi.org/10.1186/s12931-024-02777-3

5. Minglu Xu, Mengxia Zhao, Miaomiao Zhu, Hongmei Yuan, Zhongzheng Li, Peishuo Yan, Chi Ma, Huabin Zhao, ShenghuiWang, Ruyan Wan, Lan Wang*, Guoying Yu*.Hibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells. Scientific Reports. (2024) 14:8102. https://doi.org/10.1038/s41598-024-58439-3

6. Peishuo Yan, Jingyi Liu, Zhenwei Li, Jiawei Wang, Zhao Zhu, LanWang*，Guoying Yu *. Glycolysis Reprogrammingin Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the LungInt. J. Mol. Sci. 2024, 25, 315. https://doi.org/10.3390/ijms25010315

7. Peishuo Yan, Kun Yang, Mengwei Xu, Miaomiao Zhu, Yudi Duan, Wenwen Li, Lulu Liu, Chenxi Liang, Zhongzheng Li, XinPan, Lan Wang*, Guoying Yu*. CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α mediated lactate production. Journal of Molecular Cell Biology.2024,May

8. Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, Yaxuan Wang, Lianhui Cheng, Huibing Liu, Juntang Yang, Yajun Li, Ivan Rosas, Guoying Yu*.TRIOBP modulates β?catenin signaling by regulation of miR?29b in idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences (2024) 81:13. https://doi.org/10.1007/s00018-023-05080-4

9. Lan Wang, Hongmei Yuan,Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li, Huabin Zhao, ShenghuiWang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan,Ivan Rosas, Guoying Yu*.ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis. BBA - Molecular Basis of Disease 1870 (2024)166960

10. Lan Wang; Zhongzheng Li; Ruyan Wan; Xin Pan; Bin Li; HuabinZhao; Juntang Yang; Weiming Zhao; Shenghui Wang; Qiwen Wang; Peishuo Yan; ChiMa; Hongmei Yuan; Ivan Rosas; Chen Ding; Baofa Sun; Guoying Yu*. Single-cell RNA-seq provides new insights into therapeutic roles of thyroid hormone in the idiopathic pulmonary fibrosis,Am J Respir Cell Mol Biol, 2023 Oct;69(4):456-469. doi:10.1165/rcmb.2023-0080OC

11. Lan Wang; Minghui Zhu; Yan Li; Peishuo Yan; Zhongzheng Li; Xiuping Chen; Juntang Yang; Xin Pan; Huabin Zhao; Shenghui Wang; Hongmei Yuan; Mengxia Zhao; Xiaogang Sun; Ruyan Wan; Fei Li; Xiaobo Wang; Hongtao Yu; IvanRosas; Chen Ding; GuoyingYu*. Serum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis, Molecular & Cellular Proteomics, 2023, 22(4):1-13.doi: 10.1016/j.mcpro.2023.100524

12. Lan Wang;Wenyu Zhao; Cong Xia; Zhongzheng Li; Weiming Zhao; Kai Xu; Ningdan Wang; HuiLian; Ivan O. Rosas; Guoying Yu. TRIB3 mediates fibroblast activation and fibrosis though interaction with ATF4 in IPF, International Journal of Molecular Sciences, 2022, 23(24):1-17. doi: 10.3390/ijms232415705

13. Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan,Weiming Zhao, Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas and Guoying Yu*. Fenbendazole attenuates bleomycin-Induced pulmonary fibrosis in mice via suppression of fibroblast-to-myofibroblast differentiation. Int J Mol Sci. 2022 Nov 15;23(22):1-14. doi: 10.3390/ijms232214088

14. Yaxuan Wang, Lan Wang, Shuaichen Ma, Lianhui Cheng, Guoying Yu*. Repair and regeneration of the alveolar epithelium in lung injury.The FASEB journal, 2024;38(8), e23612. https://doi.org/10.1096/fj.202400088R

15. Ruyan Wan, Lan Wang, Miaomiao Zhu, Wenwen Li, Yudi Duan and Guoying Yu*. Cellular Senescence:A Troy Horse in Pulmonary Fibrosis. Int. J. Mol. Sci. 2023, 24(22), 16410; https://doi.org/10.3390/ijms242216410

16. Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu*. ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts. Cell Death Discovery; doi:10.1038/s41420-023-01702-9

17. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, YuexiaYang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li,Ivan Rosas, Lan Wang* and GuoyingYu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Respiratory Research (2023) 24:318. https://doi.org/10.1186/s12931-023-02633

18. Zhongzheng Li, Liu Xin, Lan Wang, Huabin Zhao, Shenghui Wang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han. Integrated analysis of single-cell RNA-seq and bulk RNA-seqreveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia. Front. Immunol. Volume 14 - 2023. doi:10.3389/fimmu.2023.1281687

19. Zhao H, Wang J, Li Z, Wang S, Yu G and Wang Lan* (2023) Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease. Frontiers in Molecular Neuroscience. 16:1280639.doi: 10.3389/fnmol.2023.1280639

20. Weiming Zhao; Lan Wang;Juntang Yang; Xinyu Chen; Xiaoshu Guo; Kai Xu; Ningdan Wang; Wenyu Zhao; CongXia; Hui Lian; Ivan Rosas; Guoying Yu*. Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration, Cell Communication and Signaling, 2023, 21(56): 1-17. doi:10.1186/s12964-023-01040-4

21. Weiming Zhao; Lan Wang;Yaxuan Wang; Hongmei Yuan; Mengxia Zhao; Hui Lian; Shuaichen Ma; Kai Xu; Zhongzheng Li; Guoying Yu*. Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis, International Journal of Molecular Sciences, 2023,24(10):8749-8766. doi: 10.3390/ijms24108749

22. Juntang Yang, Xin Pan, Min Xu,Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu*.Down regulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts. Respiratory research(2024),25(1), 176. https://doi.org/10.1186/s12931-024-02816-z

23. Juntang Yang; ChenxiLiang; Lulu Liu; Lan Wang; Guoying Yu*. High-Fat Diet RelatedLung Fibrosis-Epigenetic Regulation Matters, Biomolecules, 2023, 13(3):558-575.doi: 10.3390/biom13030558

24. Zhongzheng Li; ShenghuiWang; Huabin Zhao; Peishuo Yan; Hongmei Yuan; Mengxia Zhao; Ruyan Wan; Guoying Yu; Lan Wang*. Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports, 2023, 13(1):1-15. doi: 10.1038/s41598-023-28536-w

25. Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu*. Inhibition of MAD2L1 mediates pulmonary fibrosis through impairment of mitochondrial function and induction of cell senescence. Can Respir J. 2022 Oct 4;2022:1-13. doi:10.1155/2022/9663354

26. Lan Wang,，Ming Lu Xu,，Ling Xin，Chi Ma,，Guoying Yu. Oxidative stress induced apoptosis mediated anticancer activity of Rhus typhina fruits extract in human colon cancer. Medicinal Chemistry Research 2019,28:917–925

27. Lan Wang, Ming Lu Xu, Jie Liu , You Wang , Jian HeHu, Myeong-Hyeon Wang. Sonchus asper extracti nhibits LPS-induced oxidative stress and pro-inflammatory cytokine productionin RAW264.7 macrophages. Nutrition Research and Practice, 2015;9(6):579-585

28. Wang Y, Gong W, ZhouH, Hu Y, Wang L, Shen Y, Yu Guoying, Cao J. A novel miRNA fromegg-derived exosomes of Schistosoma japonicum promotes liver fibrosis in murine schistosomiasis. Front. Immunol., 27 April 2022| https://doi.org/10.3389/fimmu.2022.860807.

29. Juntang Yang, Xin Pan, Lan Wang, Guoying Yu. Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis. Mol Med (2020) 26:95

30. Xiaobo Wang, Minghui Zhu, Xiaoying Mo, Yiqiang Yuan, Xia Gao,Juntang Yang, Kai Xu, Pan Xin, Lan Wang, Guoying Yu. Practice and Reflection on the Ethical Review on Covid-19 Pandemic. Cancer Stud Ther J 5(2):1–4, 2020

31. Minghui Zhu, Ruyan Wan, Fei Li, Xiaobo Wang, Hongtao Yu, Lan Wang, Guoying Yu. Serum biomarkers in idiopathic pulmonary fibrosis. International Journal of Respiratory. 2020,12, (40),23,1801-1805

32. Yong-Chao Li, Lan Wang, Ben-zhai Hai and Ming-Lu Xu. Effect of Various Treatment Methods on the Bisphenol A Concentration in Edible Mushroom Segments during Cultivation. Advance Journal of Food Science and Technology 13(1): 40-48, 2017

33. Lan Wang, Ming Lu Xu, Jian He Hu,S?ren K. Rasmussen, Myeong-Hyeon Wang. Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells - Involvement of ROS generation and polyamine depletion. Food and Chemical Toxicology 2011, 49:149-154.

34. Lan Wang, Ming Lu Xu, Li Jie Guo , Lin Song Wang. Antioxidant activities and phenolic compounds of various extracts of Rhus typhina fruits and leaves. Advance Journal of Food Science and Technology 2015 ,7(4): 223-229.

35. Lan Wang, Hee Jeong Son, Ming-LuXu, Jian-He Hu, and Myeong-Hyeon Wang*. Anti-inflammatory and anticancer properties of dichloromethane and butanol fractions from the stem bark of Broussonetia papyrifera. Journal Korean Social Application Biology Chemistry 2010, 53(3):297-303.

36. Lan Wang, Ming Lu Xu, S?ren K.Rasmussen, Myeong-Hyeon Wang*. Vomifoliol 9-O-α-arabinofuranosyl(1→6)-β-D-glucopyranoside from the leaves of Diospyros Kaki stimulates the glucose uptake in HepG2 and 3T3-L1cells. Carbohydrate Research. 2011, 346:1212-1216. 

37. Lan Wang, Gui-Fang Xu, Xiao-Xia Liu,Ai-Xia Chang, Ming-Lu Xu, Amal Kumar Ghimeray, Jing-Pei Piao and DongHa Cho*.In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction from Liriodendron tulipifera.  Journal of Medicinal Plants Research 2012, 6(3):424-432.

38. Ming-Lu Xu,，Lan Wang, Gui-FangXu, Jian-He Hu, and Myeong-Hyeon Wang*. Antioxidant and anti-proliferative activities of different solvent fractions from methanol extracts of Sparganiun stoloniferum. Horticulture Environment and Biotechnology. 2010, 51(6):539-544.  

39. Li Wang, Lan Wang, Fang-JunLi, Lin-Song Wang*, and Myeong-Hyeon Wang Modulation of endogenous peroxidase by exogenous peroxidase in chinese red radish seedling. Hort. Environ.Biotechnol. 2011, 52(5):448-454.

40. Huan Liu, Lan Wang, and Myeong-Hyeon Wang*. Antioxidant and nitric oxide release inhibition activities of methanolic extract from Manyflower Glorybower. Horticulture, Environment, andBiotechnology. 2011, 52(3):1-6.

41. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities and related polyphenolic constituents of the methanol extract fractions from Broussonetia papyrifera stem bark and wood. Food Sci. Biotechnol. 2010, 19(3):677-682.

42. Xiao Xia Liu, Lan Wang,Yu Jie Wang, Li Ling Cai. D-glucose Enhanced 5-Aminolevulinic Acid Productionin Recombinant Escherichia coli Culture. 2010, 160:822-830.

43. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities andrelated polyphenolic constituents of the methanol extract fractions from Broussonetia papyrifera stem bark andwood. Food Sci. Biothechnol. 2010, 19(3):677-682.

44. Ming-Lu Xu, Lan Wang andMyeong-Hyeon Wang*. The Antioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera. Korean J. PlantRes. 2011, 24(1):23-29.

45. Ming-LuXu, Lan Wang, Gui-Fang Xu and Myeong-Hyeon Wang*. Antidiabetes and Angiotensin Converting Enzyme Inhibitory Activity of Sonchus asper (L) Hill Extract. Kor. J. Pharmacogn. 2011,42(1):61-67.

46. 朱明慧，萬汝燕,，李飛,，王曉博，于洪濤,，王蘭,，余國營。特發(fā)性肺纖維化血清生物指示物的研究,。國際呼吸雜志2020年12月第40卷第23期,，1801-05

47. 邢雙濤,，馮世杰，張一凡,，王蘭,，余國營。不同運動方式對哮喘患兒肺功能影響的網(wǎng)狀Meta分析.[J].河南師范大學(xué)學(xué)報(自然科學(xué)版),2023（02）

發(fā)明專利：

1. 王蘭,，李中正,，趙華斌，王勝輝,，余國營,。特發(fā)性肺纖維化血漿蛋白標(biāo)志物及其在制備檢測試劑或診斷工具中的應(yīng)用。ZL 2022 1 0506078.5,，國家發(fā)明專利,，2025

2.王蘭，邱宗波,，許明錄,，常愛霞，周春娥, 李建軍,。一種從火炬樹果實中提取木犀草素和木犀草素-7-O-β-D-吡喃葡萄糖苷的方法,。ZL201510050991.9，國家發(fā)明專利,，2017

3. 王蘭,，潘新，余國營,。甲狀腺激素通路活化劑抗肺纖維化的應(yīng)用,。202311399981.7

4. 王蘭，余國營,。特發(fā)性肺纖維化疾病血液診斷標(biāo)志物 CBRI 及其在制備診斷或預(yù)后工具中的應(yīng)用, 2020-11-05, 中國, 202011218094.1 (專利)

5.王蘭,，閆培碩，余國營,。特發(fā)性肺纖維化疾病診斷標(biāo)志物 CCT6A 及其制備診斷或預(yù)后工具中的應(yīng)用,2020-11-5, 中國, 202011218095.6 (專利)

6.王蘭,，余國營。特發(fā)性肺纖維化疾病診斷標(biāo)志物及其制備診斷或預(yù)后工具中的應(yīng)用, 2019-12-13, 中國, 201911277110.1 (專利)

著作：

1.《肺纖維化小鼠模型構(gòu)建,、診斷及治療》數(shù)字化教材,，高等教育出版社，主編,，2022

2.《動物源性抗菌肽》,，科學(xué)出版社，副主編，2015年

3.《基因工程》,，科學(xué)出版社,，參編，2012年

4.《生物化學(xué)》,，科學(xué)出版社,，參編，2011,，2016年

5.《生物化學(xué)習(xí)題集》,，科學(xué)出版社，參編,，2012年