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一,、教育經(jīng)歷

2003.07--2006.01美國(guó)俄亥俄州立大學(xué)生物學(xué)院生物化學(xué)系，高級(jí)研究員

2003.01--2003.07美國(guó)俄亥俄州立大學(xué)生物學(xué)院生物化學(xué)系,，博士后研究員

1999.09--2002.07北京大學(xué)藥學(xué)院,，藥物化學(xué)專業(yè),，博士

1986.09--1989.07吉林大學(xué)理論化學(xué)研究所,，物理化學(xué)專業(yè),碩士

1982.09--1986.07吉林大學(xué)化學(xué)系，有機(jī)化學(xué)專業(yè),，學(xué)士

二,、工作經(jīng)歷

2020.09-至今河南師范大學(xué)化學(xué)化工學(xué)院教授，博士生導(dǎo)師

2018.09-2020.09河南師范大學(xué)化學(xué)化工學(xué)院教授,，博士生導(dǎo)師,，研究生院院長(zhǎng)

2012.07-2018.08河南師范大學(xué)化學(xué)化工學(xué)院教授、院長(zhǎng),，省級(jí)特聘教授/博士生導(dǎo)師

1999.11-2012.07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院教授,，特聘教授/博士生導(dǎo)師

1994.11-1999.11河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院副教授

1992.07-1994.11河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院講師

1989.07-1992.07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院助教  

三、榮譽(yù)獎(jiǎng)項(xiàng)

2013年國(guó)務(wù)院特殊津貼專家

2012年全國(guó)優(yōu)秀科技工作者

2011《有機(jī)合成化學(xué)》河南省雙語教學(xué)示范精品課程

2009年河南省勞動(dòng)模范（先進(jìn)工作者）

2008年河南省優(yōu)秀專家

2005年河南省學(xué)術(shù)技術(shù)帶頭人

四,、教學(xué)科研

        教學(xué)：主要承擔(dān)本科生的《有機(jī)合成化學(xué)》和研究生的《糖及核苷化學(xué)》,、《有機(jī)藥物化學(xué)專論》教學(xué)工作；目前研究方向含糖藥物的新藥設(shè)計(jì)與合成,；有機(jī)合成及綠色合成化學(xué),；藥物研發(fā)及藥物生產(chǎn)新工藝研究。

科研：主要從事含糖藥物的新藥設(shè)計(jì)與合成,，有機(jī)合成及綠色合成化學(xué),。迄今為止,，在J. Am. Chem. Soc., ACS Catal., Green Chem., Adv. Synth. Catal., J. Med. Chem., Org. Lett., Chem. Commun., J. Org. Chem.等國(guó)際SCI源期刊上發(fā)表學(xué)術(shù)論文200余篇 (論文被引用2500余次)，以第一發(fā)明人授權(quán)美國(guó)發(fā)明專利和國(guó)際發(fā)明專利各1項(xiàng),，中國(guó)授權(quán)發(fā)明專利15項(xiàng),。

五、研究領(lǐng)域

1.含糖藥物的新藥設(shè)計(jì)與合成

2.有機(jī)合成化學(xué),，綠色有機(jī)合成

3.藥物研發(fā)和藥物生產(chǎn)新工藝研究

六,、聯(lián)系方式

電話：0373-3325250   

E-mail：[email protected]  or  [email protected]

七、主持省級(jí)以上科研項(xiàng)目 

1.2023.01-2026.12國(guó)家自然科學(xué)基金面上項(xiàng)目：鎳/可見光催化劑協(xié)同催化的高效C-糖基化新方法（22277021）

2.2019.01-2022.12河南省高層次人才特殊支持“中原千人計(jì)劃”中原領(lǐng)軍人才：新型藥物等有機(jī)功能分子的設(shè)計(jì),、合成,、結(jié)構(gòu)與性能研究

3.2017.01-2020.12國(guó)家自然科學(xué)基金（聯(lián)合）重點(diǎn)項(xiàng)目：2’,3’-環(huán)鳥苷腺苷酸類似物的設(shè)計(jì)、合成與構(gòu)效關(guān)系研究(U1604285)

4.2019.01-2022.12國(guó)家自然科學(xué)基金面上項(xiàng)目：基于前藥策略的人造TPT3-NaM堿基核苷酸跨膜轉(zhuǎn)運(yùn)系統(tǒng)的構(gòu)建及活性研究(21877026)

5.2014.01-2017.12國(guó)家自然科學(xué)基金面上項(xiàng)目：蒽醌并三（咪）唑核苷類似物的設(shè)計(jì),、合成及生物活性研究(21372065)

6.2012.01-2015.12國(guó)家自然科學(xué)基金面上項(xiàng)目：手性羥烷基蒽醌糖苷的設(shè)計(jì),、合成及生物活性研究(21172056)

7.2009.01-2011.12國(guó)家自然科學(xué)基金面上項(xiàng)目：新型蒽環(huán)類抗腫瘤先導(dǎo)化合物的水溶性糖基衍生物的合成及藥物活性研究(20872029)

8.2007.01-2009.12國(guó)家自然科學(xué)基金面上項(xiàng)目：稀有糖及蒽環(huán)類抗生素簡(jiǎn)單結(jié)構(gòu)類似物的合成及抗腫瘤活性研究(20672031)

9.1996.01-1998.12國(guó)家自然科學(xué)基金面上項(xiàng)目:無污染穩(wěn)定配體鉻載體試劑的制備及應(yīng)用基礎(chǔ)研究(29577273)

10.2011.01-2013.12教育部“長(zhǎng)江學(xué)者與創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃”創(chuàng)新團(tuán)隊(duì)（300萬）：創(chuàng)新藥物及醫(yī)藥材料的設(shè)計(jì)與合成(IRT1061)

11.2014.01-2017.12教育部“長(zhǎng)江學(xué)者與創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃”創(chuàng)新團(tuán)隊(duì)滾動(dòng)資助（300萬）：創(chuàng)新藥物及醫(yī)藥材料的設(shè)計(jì)與合成(IRT-14R15)

12.2013.01-2015.12河南省科技創(chuàng)新杰出人才計(jì)劃：手性藥物Plavix合成關(guān)鍵技術(shù)及應(yīng)用（50萬）

13.2008.01-2010.12河南省杰出青年計(jì)劃（20萬）：新型蒽環(huán)類抗癌藥物的合成及藥物活性研究(084100510002)

14.2008.01-2010.12河南省高校科技創(chuàng)新研究團(tuán)隊(duì)支持計(jì)劃（60萬）：藥物分子設(shè)計(jì),、合成及活性研究(2008IRTSTHN002)

15.2007.01-2009.12河南省高校新世紀(jì)優(yōu)秀人才支持計(jì)劃（40萬）：含糖結(jié)構(gòu)的抗腫瘤,、抗病毒藥物的設(shè)計(jì)、合成與生物活性研究(2006HANCET-06)

八,、代表性論文和專利  

1.     Kai Sun, Guofeng Li, Yuyang Li, Jie Yu, Qing Zhao, Zhiguo Zhang, Guisheng Zhang, Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin-6(5H)-ones,Adv. Synth. Catal.,2020,362, 1947-1954.

2.QingfengLiu,Tong-XinLiu,JinliangMa,GuishengZhang,Palladium-Catalyzed Three-Component Tandem Coupling-Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes,Org. Lett.,2020,22, 284-289.

3.  Weiwei Ma,Jingjing Bi,Chuanfang Zhao,Zhiguo Zhang,Tongxin Liu,GuishengZhang,Synthesis and biological activities of amino acids functionalized alpha-GalCer analogues,Bioorg. Med. Chem.,2020, 28,

4.  Guo-Jiang Mao,Zhen-Zhen Liang,Guang-Qi Gao,Ying-Ying Wang, Xin-Yu Guo,Li Su,Hua Zhang,Qiu-Juan Ma,Guisheng Zhang,A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke,Anal Chim. Acta,2019,1092, 117-125.

5.Qingfeng Liu, Tong-Xin Liu, Yifei Ru, Xue Zhu,Guisheng Zhang,Palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene: preparation of novel vinyl-substituted [60]fullerene-fusedtetrahydrofurans/pyrans/quinolines,Chem. Commun.,2019,55, 14498-14501.

6.  Nana Ma,Mingyue Lv,Tongxin Liu,Mengxiao Song,Yan Liu,Guisheng Zhang,Second-order nonlinear optical properties of [60]fullerene-fused dihydrocarboline derivates: a theoretical study on switch effect,J. Mater. Chem. C,2019,7, 13052-13058.

7.   Guo-Jiang Mao,Guang-Qi Gao,Zhen-Zhen Liang,Ying-Ying Wang,Li Su,Zhuo-Xi Wang,Hua Zhang, Qiu-Juan Ma,Guisheng Zhang,A mitochondria-targetable two-photon fluorescent probe with a far-red to near-infrared emission for sensing hypochlorite in biosystems,Anal Chim. Acta,2019,1081, 184-192.

8.  Zhiguo Zhang, Xiang Li,Mengmeng Song,Yameng Wang,Dan Zheng,Guisheng Zhang,Gong Chen,Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation,J. Org. Chem.,2019,84, 12792-12799.

9.     Tong-Xin Liu,Juan Wei,Pengling Zhang,Yifei Ru,Jinliang Ma,Xingjie Zhang,Nana Ma, Guisheng Zhang,Copper-Catalyzed N-H/C-H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-FusedTetrahydrocyclopenta[b]indoles,Org. Lett.,2019,21, 6461-6465.

10.Anlian Zhu,Xiaofang Xing,Shilei Wang,Donghe Yuan,Gongming Zhu, Mingwei Geng,Yuanyang Guo,Guisheng Zhang,Lingjun Li,Multi-component syntheses of diverse 5-fluoroalkyl-1,2,3-triazoles facilitated by air oxidation and copper catalysis,Green Chem.,2019,21, 3407-3412.

11.Qingfeng Liu,Tong-Xin Liu,Nana Ma,Chenhao Tu,Ruoya Wang,Guisheng Zhang,Cu(II)/Mn(III)-Promoted Synergistic Radical N-Heteroannulation Reaction: Synthesis of [60]Fullerene-Fused Tetrahydroquinoline Derivatives,J. Org. Chem.,2019,84, 7255-7264.

12.Zhiguo Zhang,Songnan Wang,Yong Zhang,Guisheng Zhang,Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors,J. Org. Chem.,2019,84, 3919-3926.

13.   Xiaopeng Zhang, Zhengwei Li, Qianqian Ding,Xiaochuan Li,Xuesen Fan, Guisheng Zhang,Alkylamino-Directed One-Pot Reaction of N-Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3-Dihydroquinazolin-4(1H)-ones,Adv. Synth. Catal.,2019,361, 976-982.

14.Guo-Jiang Mao,Zhen-Zhen Liang,Jingjing Bi,Hua Zhang,Hong-Min Meng,Li Su,Yi-Jun Gong,Suling Feng,Guisheng Zhang,A near-infrared fluorescent probe based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatoryresponse,Anal Chim. Acta,2019,1048, 143-153.

15.Yameng Wan,Zhiguo Zhang,Nana Ma,Jingjing Bi,Guisheng Zhang,Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation,J. Org. Chem.,2019,84, 780-791.

16.Tong-Xin Liu,Shuaishuai Yue,Changgeng Wei,Nana Ma,Pengling Zhang,Qingfeng Liu,Guisheng Zhang,Solvent-promoted catalyst-free regioselective N-incorporation multicomponent domino reaction: rapid assembly of -functionalized [60]fullerene-fuseddihydrocarbolines, Chem. Commun.2018,54, 13331-13334.

17.Lei Shi, Jingjing Xu, Jingjing Bi, Zhiguo Zhang, Tongxin Liu, Xiaolan Yang, Guisheng Zhang,Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds,Chinese J. Org. Chem.,2018,38, 3016-3025.

18.Nana Ma,Changgeng Wei,Shujun Li,Guisheng Zhang,Theoretical insight on ethylene polymerization catalyzed by carborane-containing metal complexes: the role of carborane,Dalton T.,2018,47, 14421-14425.

19.Lingjun Li,Shenlong Huang,Tongpeng Shang,Bo Zhang,Yuanyang Guo,Gongming Zhu,Demin Zhou,Guisheng Zhang,Anlian Zhu,Lihe Zhang,Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands,J. Org. Chem.,2018,83, 13166-13177.

20.Hao Wu,Zhiguo Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu, Guisheng Zhang,Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions,J. Org. Chem.,2018,83, 12880-12886.

21.Zhiguo Zhang,Xiaolong Gao,Haifeng Yu,Guisheng ZhangJianming Liu,Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides,Adv. Synth. Catal.,2018,360, 3406-3411.

22.Beibei Hu,Tong-Xin Liu,Pengling Zhang,Qingfeng Liu,Jingjing Bi,Lei Shi,Zhiguo Zhang,Guisheng Zhang,N-Heterocyclic Carbene-Catalyzed alpha,beta-Unsaturated Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-FusedCyclopentan-1-ones and Cyclohex-2-en-1-ones,Org. Lett.2018,20, 4801-4805.

23.Ning Lu,Zhiguo Zhang,Nana Ma,Conghui Wu,Guisheng Zhang, QngfengLiu,Tongxin Liu,Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-alpha-lodomethyl Vinylsulfones,Org. Lett.2018,20, 4318-4322.

24.Hao Wu,Zhiguo Zhang,Qingfeng Liu,Tongxin Liu,Nana Ma, Guisheng Zhang,Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o-Aminoacetophenones and Arylboronic Acids,Org. Lett.2018,20, 2897-2901.

25.Nana Ma,Jinjin Gong,Jie Zhang,Shangning Han,Mengxiao Song,Guisheng Zhang,Theoretical Exploration of the Layered Sandwich Cobaltacarborane as a Multi-State NLO Molecular Switch Triggered by Redox,J. Phys. Chem. C,2018,122, 6818-6825.

26.Zhiguo Zhang,Dan Zheng,Yameng Wan,Guisheng Zhang,Jingjing Bi,Qingfeng Liu,Tongxin Liu, Lei Shi,Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides,J. Org. Chem.2018,83, 1369-1376.

27.Shilu Xia,Tong-Xin Liu,Pengling Zhang,Jinliang Ma,Qingfeng Liu,Nana Ma,Zhiguo Zhang,Guisheng Zhang,Broad Synthesis of Disubstituted Dihydrofuran-Fused [60]Fullerene Derivatives via Cu(I)/Ag(I)-Mediated Synergistic Annulation Reaction,J. Org. Chem.2018,83, 862-870.

28.Tong-Xin Liu,Shaoshuai Hua,Nana Ma,Pengling Zhang,Jingjing Bi,Zhiguo Zhang,Guisheng Zhang,Reactivity and Synthetic Applications of alpha-Functionalized Oxime Acetates: Divergent Access to Fulleropyrrolidines and Mono- and Disubstituted 1-Fulleropyrrolines via Copper-Catalyzed Redox-Neutral N-Heteroannulation with [60]Fullerene,Adv. Synth. Catal.,2018,360, 142-152.

29.Yan Yan, Zhiguo Zhang,Yameng Wan,Guisheng Zhang,Nana Ma,Qingfeng Liu,Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles,J. Org. Chem.2017,82, 7957-7963.

30.Lingjun Li,Qianqian Li,Shengqiang Ding,Pengyang Xin,Yuqin Zhang,Shenlong Huang, Guisheng Zhang, ADP-ribosyl-N-3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds,Molecules,2017, 22, 1346.

31.Zhiguo Zhang,Yongchao Zhang,Guoqing Huang,Guisheng Zhang,Organoiodine reagent-promoted intermolecular oxidative amination: synthesis of cyclopropyl spirooxindoles,Org. Chem. Front.,2017,4, 1372-1375.

32.Xuna Zhao,Tong-Xin Liu,Nana Ma,Guisheng Zhang,In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of beta-Oxoamides with Amine Hydrochlorides for the Synthesis ofPyrrolin-4-ones,J. Org. Chem.2017,82, 6125-6132.

33.Yueyang Liu,Zhiguo Zhang,Yameng Wan,Guisheng Zhang,Zhonglian Li,Jingjing Bi, Nana Ma, Tongxin Liu, Qingfeng Liu, Oxidation of beta-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides,J. Org. Chem.,2017,82, 3901-3907.

34.Xin Wan,Kai Sun,Guisheng Zhang,Metal-free tetra-n-butylammonium bromide-mediated aerobic oxidative synthesis of beta-ketosulfones from styrenes,Sci. China Chem.,2017,60, 353-357.

35.Zhiguo Zhang,Xiaolong Gao,Zhonglian Li,Guisheng Zhang,Nana Ma,Qingfeng Liu, Tongxin Liu, PIFA-Mediated oxidative cyclization of 1-aroyl-N-arylcyclopropane-1-carboxamides and their application in the synthesis of pyrrolo[3,2-c]quinolinones,Org. Chem. Front.,2017,4, 404-408.

36.Nana Ma,Jinjin Gong,Shujun Li,Jie Zhang,Yongqing Qiu,Guisheng Zhang,Second-order NLO responses of two-cavity inorganic electrides Li-n@B20H26 (n=1, 2): evolutions with increasing excess electron number and variousB-B connection sites of B20H26,Phys. Chem. Chem. Phys.,2017,19, 2557-2566.

37.Lingjun Li,Shengqiang Ding,Yanping Yang,Anlian Zhu,Xincui Fan,Mengchao Cui,Changpo Chen,Guisheng Zhang,Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling,Chem. Eur. J.,2017,23, 1166-1172.

38.Xiaopeng Zhang,Shuxiang Dong,Xueli Niu,Zhengwei Li, Xuesen Fan, Guisheng Zhang,Palladium-Catalyzed Ortho-Selective C-H Oxidative Carbonylation of N-Substituted Anilines with CO and Primary Amines for the Synthesis of o-Aminobenzamides,Org. Lett.,2016,18, 4634-4637.

39.Tong-Xin Liu, Jinliang Ma,Di Chao,Pengling Zhang,Nana Ma, Qingfeng Liu,Lei Shi,Zhiguo Zhang,Guisheng Zhang,Synthesis of C-60-Fused Tetrahydrocarbazole/Dibenzothiophene/Benzothiophene and Dibenzofuran Derivatives via Metal-Free OxidativeDehydrogenative Carboannulation,Org. Lett.,2016,18, 4044-4047.

40.Zhiguo Zhang,Jingjing Qian,Guisheng Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu,Kai Sun,Lei Shi,Copper(I) catalyzed C(sp(2))-N bond formation: synthesis of pyrrolo[3,2-c]quinolinone derivatives,Org. Chem. Front.,2016,3, 344-348.

41.Yi-Jun Gong,Xiao-Bing Zhang,Guo-Jiang Mao,Li Su,Hong-Min Meng,Weihong Tan,Suling Feng,Guisheng Zhang,A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast,Chem. Sci.,2016,7, 2275-2285.

42.Di Chao,Tong-Xin Liu,Nana Ma,Pengling Zhang,Zheng Fu,Jinliang Ma,Qingfeng Liu, FengjinZhang,Zhiguo Zhang,Guisheng Zhang,Silver(I)-mediated three-component annulation reaction of [60]fullerene, sulfonylhydrazones, and nitriles: leading to diverse disubstituted[60]fullerene-fused dihydropyrroles,Chem. Commun.,2016,52, 982-985.

43.Kai Sun,Xin Wang,Lulu Liu,Jingjing Sun,Xin Liu,Zhenduo Li,Zhiguo Zhang, Guisheng Zhang,Copper-Catalyzed Cross-Dehydrogenative C-N Bond Formation of Azines with Azoles: Overcoming the Limitation of Oxidizing N-O Activation Strategy,ACS Catal.,2015,5, 7194-7198.

44.Zhiguo Zhang,Feisong Zhang,Huanhuan Wang,Hao Wu,Xinyu Duan,Qingfeng Liu,Tongxin Liu,Guisheng Zhang, Catalyst-Free Domino Reaction of 1-Acryloyl-1-N-arylcarbamyl-cyclopropanes with Amines: One-Pot Approach to 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones,Adv. Synth. Catal.,2015,357, 2681-2686.

45.Zhiguo Zhang,Junlong Li,Guisheng Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu,Iron-Catalyzed Intramolecular C(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives,J. Org. Chem.,2015,80, 6875-6884.

46.Tong-Xin Liu,Jinliang Ma,Di Chao,Pengling Zhang,Qingfeng Liu,Lei Shi, Zhiguo Zhang, Guisheng Zhang,AgNO2-mediated cleavage of the N-N bond of sulfonylhydrazones and oxygen transfer: access to fulleroisoxazolines via radical cyclization with[60]fullerene,Chem. Commun.,2015,51, 12775-12778.

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3. 多重耐藥抗癌藥蒽環(huán)類,，授權(quán)發(fā)明專利號(hào)：200680016329.0。

4. 一種用于化學(xué)反應(yīng)過程中的新型分水器, 授權(quán)實(shí)用專利號(hào)：201020181503.0,。

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