郝二軍
| 郝二軍,，男,， 博士，副教授，藥物化學及生物與醫(yī)藥專業(yè)碩士生導師,， 產(chǎn)學研中心主任,，民盟河南師范大學委員會副主委，河南省知識產(chǎn)權專家?guī)鞂＜遥?/span>聯(lián)系電話：0373-3326335,，E-mail:[email protected]
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教育與研究經(jīng)歷： 2014.3-2019.12 河南師范大學化學博士后流動站博士后（合作導師：郭海明 教授） 其中：2014.08-2015.08 受省委組織部派遣河南省博士服務團到許昌豪豐化學科技有限公司掛職副總經(jīng)理,； 2017.10-2019.10 借調河南師范大學科技處大健康中心平臺秘書； 2020.12-至今 河南師范大學化學化工學院產(chǎn)學研中心主任,。 主講課程： 1,、手性核苷類藥物的設計與不對稱合成研究； 2,、含氮雜環(huán)化合物抗腫瘤,、抗病毒活性、構效關系及作用機制研究； 3,、光催化電催化酶催化不對稱合成研究,。 近期發(fā)表的代表性論文： 23.Xian-Jia Li, Meng-Cheng Zhang, Xiang Li, Lu-Lu Guan, Yu-Ru Liang*, Er-Jun Hao*,Yang Wang,* Hai-Ming Guo*, Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction,J. Med. Chem. 2025, 68,5573-5596.(國際藥學領域頂尖期刊,Highlight by 化學谷 )
22. Er-Jun Hao,*Yan Zhao, Min Yu, Xian-Jia Li, Ke-Xin Wang, Fu-Ying Su, Yu-Ru Liang,* Yang Wang,* Hai-Ming Guo*,Discovery, Synthesis and Activity Evaluation of Novel Five-membered Sulfur-containing Heterocyclic Nucleosides as Potential Anticancer Agents in Vitro and in Vivo, J. Med. Chem. 2024, 67, 12553-12570.（國際藥學領域頂尖期刊, Highlight by ACS、CBG,、cDRUGS和X-MOL, Top）
21.Er-Jun Hao, Gong-Xin Li, Yu-Ru Liang, Ming-Sheng Xie, Dong-chao Wang, Xiao-Han Jiang, Jia-Yi Cheng, Zhi-Xian Shi, Yang Wang,* Hai-Ming Guo*;Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo, J. Med. Chem. 2021, 64, 2077-2109. (國際藥學領域頂尖期刊, Highlight by CBG和X-MOL, Top, IF8.039)
20.Yuqing Chen;Xin Wang; Jing-Ran Shan; Zhixian Wu, Renxu Cao;Yonghong Liu;Yunhe Jin,Erjun Hao*;K. N. Houk*; Lei Shi* ,Chemoselective Functionalization of Tertiary C-H Bonds of Allylic Ethers: Enantioconvergent Access to sec,tert-Vicinal Diols，Angew. Chem. Int. Ed. 2025,e202501924.(化學領域頂尖期刊,，SCI一區(qū),，Top，IF16.1)
19. Yuqing Chen; Huaipu Yan; Qian Liao*; Dandan Zhang; Shuangjie Lin;Erjun Hao*; Rukhsana Murtaza;Chenchen Li; Chao Wu; Chunying Duan;Lei shi*;Synthesis of Homoallylic Amines by Radical Allylation of Imines with Butadiene under Photoredox Catalysis,，Angew. Chem. Int. Ed. 2022,e202204516.(化學領域頂尖期刊,，SCI一區(qū)，Top,，IF16.823)
18.Yonghong Liu, Zhixian Wu, Jingran Shan*, Huaipu Yan, Er-Jun Hao*, Lei Shi*,Titanium catalyzed [2σ+2π] cycloaddition of bicyclo[1.1.0]-butanes with 1,3-dienes for ef?cient synthesis of stilbene bioisosteres, Nature Comm. 2024, 15,4374. (化學領域頂尖期刊,，SCI一區(qū)，Top,，IF16.6)
17. Er-Jun Hao, Dan-Dan Fu, Dong-Chao Wang*, Tao Zhang, Gui-Rong Qu,，Gong-Xin Li，Yu Lan*, Hai-Ming Guo*,，Chemoselective Asymmetric Dearomative [3+2] Cycloaddition Reactions of Purines with Aminocyclopropanes,， Org. Chem. Front. 2019,6,863-867. (SCI一區(qū)，Top, IF5.456)
16. Er-Jun Hao, Gong-Xin Li, Zhen-Zhen Lv, Fu-Sheng Li, Yu-Qing Chen, Shuang-Jie Lin, Cai-Zhe Shi, and Lei Shi*,，“In-Situ Immobilization” of Multicomponent Chiral Catalyst (MCC) via Non-covalent Interactions for Heterogeneous Asymmetric Hydrogenation Reactions,，Org. Chem. Front. 2020, 7, 345-349. (SCI一區(qū)，Top, IF5.456)
15.Erjun Hao*, Binghui Lu,，Yonghong Liu, Tianxiao Yang, Huaipu Yan, Xiaobo Ding, Yunhe Jin, Lei Shi*,，Difunctionalization of 1,3-Butadiene via Sequential Radical Thiol-ene Reaction and Allylation by Dual Photoredox and Titanium Catalysis，Org. Lett. 2023, 25(27), 5094-5099.(SCI一區(qū),，Top,，IF5.2)
14.Chun Zhang*，Yangbo Cui,，Xiaoyu Zhou,，Yichen Pan，Junqi Zhang,，Dandan Hu,，Hai-Ming Guo，Er-Jun Hao*,，Hongjun Ren* Pd-Catalyzed Decarboxylative Negeshi Coupling of Zinc Aryl Carboxylates with Arylthianthrenium Salts, Org. Lett. 2025, 67（9）, 2256-2261.(SCI一區(qū),，IF=4.9)
13.Huaipu Yan, Dandan Zhang, Yonghong Liu, Xin Wang, Zhixian Wu, Yunhe Jin, Xiaobo Ding, Jingran Shan, Erjun Hao*, Lei Shi*； Photoredox chromium and cobalt dual catalysis for carbonyl allylation with butadiene via allyl radical intermediates,Org. Chem. Front. 2024,11, 684-689. (SCI一區(qū)，IF=5.4,，Top)
12.Huaipu Yan,Jing-Ran Shan,Fengzhi Zhang, Yuqing Chen, Xinyi Zhang, Qian Liao, Erjun Hao*, Lei Shi*; Radical Crotylation of Aldehydes with 1,3-Butadiene by Photoredox Cobalt and Titanium Dual Catalysis,，Org. Lett. 2023, 25,7694-7699.(SCI一區(qū)，Top,，IF5.2)
11. Shuang-Jie Lin, Yu-Qing Chen, Huai-Pu Yan, Yong-Hong Liu, Yu-Chen Sun, Er-Jun Hao*, Cai-Zhe Shi, Dan-Dan Zhang, Nan Zhu, and Lei Shi*,；Activation of Chromium Catalysts by Photoexcited Hantzsch Ester for Decarboxylative Allylation of Aldehydes with Butadiene，Org. Lett. 2021, 23(20), 8077–8081.(SCI一區(qū),，Top,，IF6.072)
10.Lei Shi*, Yong-Hong Liu, Xuehan Qi, Renxu Cao, Yihe Zhu, Jing-Ran Shan, Er-Jun Hao*, Yunhe Jin and xiao Feng*; Rapid Access to Azetidines via Allylation of Azabicyclo[1.1.0]butanes by Dual Copper/Photoredox Catalysis, Chem. Commun. 2025, 61,6352-6355.（SCI二區(qū)）
9. Yonghong Liu,Huaipu Yan, Yuqing Chen, Erjun Hao,* Lei Shi,* Photoinduced copper-catalyzed selective three-component 1,2-amino oxygenation of 1,3-dienes, Chem.Comm. 2023,59,10388-10391. (SCI二區(qū))
8. Jie Ma, Rong Feng, Hao-Lin Zhou, Er-Jun Hao*, Zhen Shi, and Zhi-Bing Dong*,One Pot Synthesis of N,N-diphenyl-2-benzothiazolamines from 1-(2-Iodophenyl)-3-phenylthioureas and Iodobenzenes, J. Org. Chem. 2022, 87(21), 14342–14351. (SCI二區(qū)) 7. Xi Wang, Jin-Quan Chen, Xing-Xing Yang, Er-Jun Hao*, Zhi-Bing Dong*,Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: a Practical C(sp2)-S Bond Construction, Eur. J. Org. Chem. 2022,e202200015.(IF3.261) 6.Yue-Xiao Wu; Kang Peng, Zhi-Chao Hu, Yong-Hao Fan, Zhen Shi; Er-Jun Hao*; Zhi-Bing Dong*; Iodine-mediated cross dehydrogenation coupling of heterocyclic thiols with amines: an easy and practical formation of S-N bond, Eur. J. Org. Chem. , 2021,43: 5889-5894. (IF3.261) 5. Pei-Hua Zhao*, Kuan-Kuan Xiong, Wen-Jun Liang, Er-Jun Hao*，Synthesis, crystal structures and electrocatalytic properties of bridgehead-C- functionalized diiron dithiolate complexes,，J. Coord. Chem. 2015, 68,968-979. 4.Gao, Chun; Liu, xin; Wang, Minghui; Liu, Shuxian; Zhu, Tingting; Zhang, Yikang; Hao, Erjun*; Yang, Qiliang*;Advances in Electrochemical Asymmetric Synthesis,，Chin.J.Org.Chem. 2024,44,673-727. 3.Hao, Erjun*, Ding, Xiaobo, Wang, Kexin, Zhou, Honghao, Yang, Qiliang, Shi, Lei*. Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds[J]. Chinese Journal of Organic Chemistry,Chin.J.Org.Chem. 2023, 43：4057-4074. 2. Er-Jun Hao, Qing Zhang, Qi-Ying Zhang*,Gui-Rong Qu, Xi-Ning Yang, Hai-Ming Guo*, Efficient Synthesis of Spirocyclic Nucleosides via Michael-initiated Intermolecular Cyclopropanation Reaction, Chin.J.Org.Chem. 2019, 39,3237-3243. 1. Er-Jun Hao, Xiao-Han Jiang, Dan-Dan Fu, Dong-Chao Wang*, Ming-Sheng Xie, Hai-Ming Guo, Synthesis of 3-Cyanomethyl Oxoindoles via Palladium- catalyzed Domino Heck/Cyanation Reaction in Water, Chin.J.Org. Chem. 2016, 36, 2746-2751. 近年來主持的主要科研項目: 2、河南省高等學校重點科研項目（21A150002）,，2021.01-2022.12,； 3、河南省博士后基金項目（一等資助）(2015071),，2016.01-2019.12,； 4、河南省產(chǎn)學研項目142107000082 ）,，2015.01-2018.10,； 5、河南省高等教育教學改革研究與實踐重點項目（2021SJGLX105）,，2022.01-2023.12,。 6、河南省教育廳教師教育課程改革研究重點項目（2014-JSJYZD-012）,，2014.07-2016.07,； 7、河南省教師教育課程改革一般項目（2020-JSJYYB-026 ）,，2020.06-2021.06,； 8、企業(yè)橫向科技合作項目(H20200003),，2020.03-2024.03; 9,、企業(yè)橫向科技合作項目(HJX201819)，2013.11-2018.10,； 10,、河南師范大學研究生教育改革與質量提升工程項目：研究生課程思政示范課程項目,，現(xiàn)代藥劑學選論（XY2023SZ02），2023.03-2025.03,。 近年來參加的主要科研項目: 1,、國家自然科學基金聯(lián)合基金重點項目：糖雜環(huán)核苷的設計合成、抗腫瘤活性及構效關系研究,，U22A20378,，2023.01-2026.12，參與,，在研,； 2、國家自然科學基金：電化學調控的不對稱反應合成手性碳環(huán)核苷,，21602045，2017.01-2019.12,，參與（第二參與人）,，已結題； 3,、國家自然科學基金：負載手性催化劑的毛發(fā)狀納米載體的設計及其在不對稱反應中的應用,，21204019，2013.01-2015.12,，參與（第二參與人）,，已結題； 獲得榮譽與獎勵： 1,、國培計劃,、省培計劃等培訓項目可持續(xù)發(fā)展研究與實踐，河南省教師教育教學成果獎二等獎(豫教〔2021〕58527),； 2,、吉西他濱鹽酸鹽生產(chǎn)新工藝研究，河南省人民政府,，河南省科技進步三等獎（證書編號：2012-J-256-R05/06）,； 3、河南師范大學優(yōu)秀教師,； 4,、河南師范大學優(yōu)秀班主任； 5,、河南師范大學優(yōu)秀實習指導教師,； 6、優(yōu)秀創(chuàng)新創(chuàng)業(yè)指導老師獎,； 7,、河南師范大學文明教師,； 8、河南省教育廳優(yōu)秀科技論文二等獎,； 9,、化學化工學院優(yōu)秀共產(chǎn)黨員； 10,、挑戰(zhàn)杯優(yōu)秀指導老師獎,； 11、河南省優(yōu)秀盟員,。 代表性授權國家發(fā)明專利： 1,、郝二軍、郭海明等,；[3+2]環(huán)加成不對稱脫芳構化合成手性非芳香嘌呤核苷的方法,，授權專利號：ZL201810894271.4； 2,、郝二軍,、郭海明等；一種磷酸氟達拉濱的制備方法,，授權專利號：ZL201610278259.1,； 3、郝二軍,、郭海明等,；一種合成2′-螺環(huán)基取代的三元碳環(huán)核苷的方法，授權專利號：ZL201910374991.2,。 4,、郭海明、王洋,、郝二軍等,；非環(huán)核苷先導化合物及其制備方法和在制藥中的應用，授權專利號：ZL202011489709.4,。 English version: Dr. Er-Jun Hao School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang, 453007, China E-mail: [email protected] Tel: +86-03733326335 . Education and Academic career： Lecturer, Henan Normal University, China(2008) Ph.D.: Nankai University, China (2010, supervisor: Prof. Xiao-Qing Zhu and Prof. Jin-Pei Cheng) M.S.: Henan Normal University, China (2005) B.S.: Henan Normal University, China (2002) Major Research Interests： 1. Design and synthesis of chiral nucleoside drugs,； 2. Antitumor activity and structure-activity relationship study； 3. Photocatalytic and Electrocatalysis and Enzyme Catalysis asymmetric synthesis,； |
