| 姓 名： | 郭海明 |
職 稱(chēng)： | 博士，教授，博士生導(dǎo)師，科技處處長(zhǎng) | |
辦公電話： | 0373-3329276 | |
電子郵箱： |
個(gè)人簡(jiǎn)介： 郭海明，博士，教授，博士生導(dǎo)師，科技處處長(zhǎng)，國(guó)家中青年科技創(chuàng)新領(lǐng)軍人才，百千萬(wàn)人才工程國(guó)家級(jí)人選，國(guó)家有突出貢獻(xiàn)中青年專(zhuān)家，教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃獲得者，河南省學(xué)術(shù)技術(shù)帶頭人，河南省杰出人才基金獲得者，河南省杰出青年基金獲得者，河南省青年科技獎(jiǎng)獲得者，河南創(chuàng)新型科技團(tuán)隊(duì)及高校科技創(chuàng)新團(tuán)隊(duì)帶頭人。曾任河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院兼職本科生輔導(dǎo)員，助教，副教授，碩士生導(dǎo)師，教授，博士生導(dǎo)師，副院長(zhǎng)，期間，美國(guó)Scripps研究所，分子生物學(xué)專(zhuān)業(yè)，博士后；河南師范大學(xué)化學(xué)化工學(xué)院教授，博士生導(dǎo)師，教務(wù)處副處長(zhǎng)，博士生導(dǎo)師，科技處處長(zhǎng)。主講課程本科生《波譜分析》，《有機(jī)化學(xué)及實(shí)驗(yàn)》，研究生《不對(duì)稱(chēng)合成》，《有機(jī)及藥物化學(xué)專(zhuān)論》。 | 研究領(lǐng)域： |
1.不對(duì)稱(chēng)合成； 2.核苷合成方法學(xué)研究； 3.分子的熒光標(biāo)記與熒光識(shí)別； 4.核苷類(lèi)藥物的設(shè)計(jì)與合成。 | |
主要學(xué)術(shù)及社會(huì)兼職： | |
主持或參加科研項(xiàng)目情況： | |
1.河南省科技創(chuàng)新杰出人才（164200510008），通過(guò)環(huán)加成反應(yīng)合成糖雜核苷類(lèi)似物，2016.1-2017.12，項(xiàng)目主持人； 2.973計(jì)劃前期研究專(zhuān)項(xiàng)（2014CB560713），具有抗病毒活性的手性非環(huán)核苷類(lèi)藥物的新合成策略研究，2014.10-2016.8，項(xiàng)目主持人； 3.國(guó)家自然科學(xué)基金（21472037），基于9-聯(lián)烯嘌呤構(gòu)建環(huán)狀大小不同的手性碳環(huán)核苷，2015.1-2018.12，項(xiàng)目主持人； 4.國(guó)家自然科學(xué)基金（21272059），三環(huán)及多環(huán)核苷的設(shè)計(jì)、合成及在熒光標(biāo)記中的應(yīng)用，2013.1-2016.12，項(xiàng)目主持人； 5.國(guó)家自然科學(xué)基金（21072047），手性非環(huán)核苷類(lèi)化合物的設(shè)計(jì)、合成及其藥物活性研究，2011.1-2013.12，項(xiàng)目主持人； 6.國(guó)家自然科學(xué)基金（20802016）, 嘌呤類(lèi)核苷新化合物的合成及方法學(xué)研究, 2009.1-2011.12，項(xiàng)目主持人； 7.高等學(xué)校博士學(xué)科點(diǎn)專(zhuān)項(xiàng)科研基金（博導(dǎo)類(lèi)）（20124104110006），“具有熒光活性多環(huán)核苷的綠色合成研究”，2013.1-2015.12，項(xiàng)目主持人； 8.教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃（NCET-09-0122），“冠醚-嘌呤核苷綴合物的合成及其藥理活性研究”，2010.1-2012.12，項(xiàng)目主持人； 9河南杰出青年基金（114100510012），“新型手性非環(huán)核苷類(lèi)化合物的設(shè)計(jì)及合成研究”，2011.1-2013.12，項(xiàng)目主持人； 10.河南省高校科技創(chuàng)新研究團(tuán)隊(duì)支持計(jì)劃(2012IRTSTHN006)：“功能有機(jī)分子的設(shè)計(jì)、合成及活性研究” 2012, 1-2014, 12.團(tuán)隊(duì)負(fù)責(zé)人； 11.河南省科技開(kāi)放合作項(xiàng)目（132106000068）：“腺苷蛋氨酸的合成及產(chǎn)業(yè)化”，2014.1-2015.12，項(xiàng)目主持人； 12.河南省高等教育教學(xué)改革研究項(xiàng)目（2009SJGLX145）“化學(xué)類(lèi)專(zhuān)業(yè)人才培養(yǎng)方案與課程體系綜合改革與實(shí)踐”，2009.9-2011.9，項(xiàng)目主持人； 13.河南省高等教育教學(xué)改革研究項(xiàng)目（）, “分流培養(yǎng)模式下教學(xué)質(zhì)量保障體系的探索與實(shí)踐”，2012.1-2013.12，項(xiàng)目主持人； 14.新鄉(xiāng)市科技創(chuàng)新平臺(tái)建設(shè)項(xiàng)目（），“新型手性非環(huán)核苷類(lèi)藥物的設(shè)計(jì)與合成”，2012-2014，項(xiàng)目主持人； 15.企業(yè)橫向項(xiàng)目，“三種阿糖核苷的合成方法及產(chǎn)業(yè)化研究”，2009.8-2010.8，項(xiàng)目主持人。 16.河南師范大學(xué)杰出青年基金，“手性非環(huán)核苷的不對(duì)稱(chēng)合成”，2011.1-2013.12，項(xiàng)目主持人。 17.國(guó)家自然科學(xué)基金（20772025），5-取代嘧啶碳環(huán)核苷的合成及生物活性研究, 2008.1-2010.12，第3參加人； 18.國(guó)家自然科學(xué)基金（20772024），脫氧核苷的合成新方法新方法研究, 2008.1-2010.12，第3參加人； 19.國(guó)家自然科學(xué)基金（29972010），微波技術(shù)合成核苷類(lèi)化合物的新方法研究, 2003.1-2006.12，第5參加人； 20.國(guó)家自然科學(xué)基金（20472082），手性有機(jī)小分子催化劑設(shè)計(jì)及其在不對(duì)催化反應(yīng)中的應(yīng)用, 2004.1-2007.12，第4參加人； 21.河南省杰出人才創(chuàng)新基金(074200510020)，綠色合成技術(shù)在脫氧及氟代核苷的合成及產(chǎn)業(yè)化中的應(yīng)用研究, 2008.1-2010.12，第3參加人。 | |
學(xué)術(shù)成果： | |
代表性論文： [1] Dong-Chao Wang, Ming-Sheng Xie, Hai-Ming Guo*, Gui-Rong Qu, Meng-Cheng Zhang, Shu-Li You*, Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles, Angew. Chem. Int. Ed. 2016, in press.
[2] Dan-Jie Zhang, Ming-Sheng Xie*, Gui-Rong Qu, Yao-Wei Gao, and Hai-Ming Guo*, Synthesis of Azacyclic Nucleoside Analogues via Asymmetric [3 + 2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines, Org. Lett., 2016, 18(4), 820–823.
[3] Dong-Chao Wang, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu* and Hai-Ming Guo*, Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via?Domino Heck–Sonogashira Reaction in Water, Adv. Synth. Catal., 2016, 358: 494–499.（as a VIP paper. see Inside cover）
[4] Hua Zhang*, Kui Wang, Xiao-peng Xuan, Qing-zhang Lv, Ya-min Nie, Hai-ming Guo*, Cancer Cells-Targeted Two-Photon Fluorescence Probe for the Real-time Ratiometric Imaging of DNA Damage, Chem. Commun., 2016,52, 6308-6311.
[5] Dong-chao Wang, Ran Xia, Ming-sheng Xie, Gui-rong Qu*, Hai-ming Guo*, Synthesis of Cycloalkyl Substituted Purine Nucleosides via a Metal-Free Radical Route, Org. Biomol. Chem., 2016, 14, 4189-4193. (Invited paper )
[6] Huan-Li Sun, Fei Chen, Ming-Sheng Xie, Hai-Ming Guo*, Gui-Rong Qu, Yan-Mei He, Qing-Hua Fan*, Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues, Org. Lett., 2016, 18 (9), 2260–2263.
[7] ????Jianping Li, Yanyan Zhang, Hua Zhang*, Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu, Haiming Guo??*, ??Nucleoside-based Ultrasensitive FluorescentProbe for the Dual-mode Imaging of Microviscosity in Living Cells, Anal.Chem., 2016, 88 (10), 5554–5560.
[8] Hai-Xia Wang, Dan-Dan Xi, Ming-Sheng Xie*, Hui-Xuan Wang, Gui-Rong Qu, Haiming Guo*Nucleoside-Based Diarylethene Photoswitches: Synthesis and Photochromic Properties, ChemBioChem, 2016, 17(13), 1216–1220.
[9] Ming-Sheng Xie, Peng Zhou, Hong-Ying Niu, Gui-Rong Qu*, Hai-Ming Guo*, Enantioselective Intermolecular Cyclopropanations for the Synthesis of Chiral Pyrimidine Carbocyclic Nucleosides, Org. Lett., 2016, 18(17), 4344–4347. (highlighted by Synfacts )
? ? [10] Peng Zhou, Ming-Sheng Xie, Gui-Rong Qu*, Ren-Long Li, Hai-Ming Guo*, Synthesis of Acyclic Nucleoside Analogues via the Insertion of Carbenoids into N-H Bond of Nucleobases, Asion J. Org. Chem. 2016, 5, 1100–1106.
[11]Hui-Li Liu, Ming-Sheng Xie*, Gui-Rong Qu, and Hai-Ming Guo*, Organocatalytic Enantioselective Allylic Etherification of Morita–Baylis–Hillman Carbonates and Silanols, J. Org. Chem., 2016, DOI: 10.1021/acs.joc.6b01931. [12]Ming-Sheng Xie, Yong Wang, Jian-Ping Li,* Cong Du, Yan-Yan Zhang, Er-Jun Hao, Yi-Ming Zhang, Gui-Rong Qu, Hai-Ming Guo* A Straightforward Entry to Chiral Carbocyclic Nucleoside Analogues via Enantioselective [3+2] Cycloaddition of -Nucleobase Substituted Acrylates, Chem. Commun.,2015, 51, 12451 - 12454.
[13]Hua Zhang*, Caixia Wang, Tao Jiang, Haiming Guo*, Ge Wang, Xinhua Cai, Lin Yang, Yi Zhang, Haichuan Yu, Hui Wang, and Kai Jiang, Microtubule-Targetable Fluorescent Probe: Site-Specific Detection and Super-Resolution Imaging of Ultratrace Tubulin in Microtubules of Living Cancer Cells, Anal. Chem., 2015，87 (10), 5216–5222.
[14]Hong-Ying Niu*,Cong Du, Ming-Sheng Xie, Yong Wang, Qian Zhang,Gui-Rong Qu, and Hai-Ming Guo*,Diversity-Oriented Synthesis of Acyclic Nucleosides via Ring-Opening of Vinyl Cyclopropanes with Purines, Chem. Commun.,2015, 15, 3328-3331.
[15]Ming-Sheng Xie, Hong-Ying Niu*, Gui-Rong Qu, and Hai-Ming Guo*，The development for the synthesis of chiral acyclic nucleosides and their phosphonates,Tetrahedron Letters 55 (2014), pp. 7156-7166.（Invited Digest Paper）
[16]Qi-Liang Yang, Ming-Sheng Xie, Chao Xia, Huan-Li Sun, Dan-Jie Zhang, Ke-Xin Huang, Zhen Guo, Gui-Rong Qu*, and Hai-Ming Guo*，A rapid and divergent access to chiral azacyclic nucleoside analogues via highly enantioselective 1,3-dipolar cycloaddition of β-nucleobase substituted acrylates,Chem. Commun., 2014,50, 14809-14812.
[17]Shao-Hua Gao,Ming-Sheng Xie, Hai-Xia Wang, Hong-Ying Niu, Gui-Rong Qu,*and Hai-Ming Guo*,Highly Selective Detection of Hg2+ ion by Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensor, Tetrahedron, 2014, 70, 4929-4933.
[18]Qian Zhang*, Bai-Wei Ma, Qian-Qian Wang, Xing-Xing Wang, Xia Hu, Ming-Sheng Xie, Gui-Rong Qu, and Hai-Ming Guo*, The Synthesis of Tenofovir and its Analoguesvia Asymmetric Transfer Hydrogenation,Org. Lett. 2014,16, 2014-2017.
[19]Ren-Long Li, Lei Liang, Ming-Sheng Xie, Gui-Rong Qu,* Hong-Ying Niu, Hai-Ming Guo,*Copper-Catalyzed Intramolecular Cyclization of N-Propargyl-Adenine: Synthesis of Purine-Fused PolycyclicsJ. Org. Chem. 2014,79, 3665-3670.
[20]Jian-Ping Li, Hui-Xuan Wang, Hai-Xia Wang,* Ming-Sheng Xie, Gui-Rong Qu, Hong-Ying Niu, Hai-Ming Guo,*Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensors for the Selective Detection of Pd2+ in Aqueous Buffer,Eur. J. Org. Chem.2014, 2225-2230.
[21]Qian Zhang,* Yong-Zhen Huang, Jun-Hui Yang, Bai-Wei Ma, Gui-Rong Qu, Hai-Ming Guo,* Synthesis of 9-oxiranyl-9H-purine derivatives in β-cyclodextrin cavity, Tetrahedron Letters2014, 55, 1203-1206.
[22]Ming-Sheng Xie; Zhi-Liang, Chu, Hong-Ying Niu, Gui-Rong Qu,* Hai-Ming Guo*, A Copper-Catalyzed Domino Route toward Purine-Fused Tricyclic Derivatives, J. Org. Chem.2014, 79, 1093-1099.
[23] Tao Wei, Ming-Sheng Xie, Gui-Rong Qu,* Hong-Ying Niu, and Hai-Ming Guo*, A New Strategy to Construct Acyclic Nucleosides via Ag(I)-Catalyzed Addition of Pronucleophiles to 9-Allenyl-9H-Purines,Org. Lett.2014, 16, 900-903.
[24]Ran Xia, Ming-Sheng Xie, Hong-Ying Niu, Gui-Rong Qu,* and Hai-Ming Guo*, Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water,Green Chem.2014, 16, 1077-1081.
[25]Ran Xia, Ming-Sheng Xie, Hong-Ying Niu, Gui-Rong Qu,* and Hai-Ming Guo,* Radical Route for the Alkylation of Purine Nucleosides at C6 via Minisci Reaction,Org. Lett.2014, 16, 444-447.
[26] Dong-Chao Wang, Hong-Ying Niu, Ming-Sheng Xie, Gui-Rong Qu,* Hui-Xuan Wang, and Hai-Ming Guo,*Highly Regioselective Three-Component Domino Heck?Negishi Coupling Reaction for the Functionalization of Purines at C6,Org. Lett.2014, 16, 262-265.
[27].Jian-Ping Li, Yu Huang, Ming-Sheng Xie,Gui-Rong Qu, Hong-Ying Niu,* Hai-Xia Wang, Bo-Wen Qin, and Hai-Ming Guo,* One-Pot Synthesis of 7,9-Dialkyl-Purin-8-One Analogues: Broad Substrate Scope, J. Org. Chem. 2013, 78, 12629-12636.(Highlighted by JOC Homepage)
[28]Hai-Ming Guo,* Run-Ze Mao, Qiao-Tian Wang, Hong-Ying Niu,Ming-Sheng Xie,and Gui-Rong Qu* , Pd(II)-Catalyzed One-Pot, Three-Step route for the Synthesis of Unsymmetrical Acridines, Org. Lett.2013, 15, 5460-5463.
[29].Qian Zhang,* Bai-Wei Ma, Yong-Zhen Huang, Qian-Qian Wang, Xing-Xing Wang, Gui-Rong Qu, and Hai-Ming Guo*Efficient Synthesis of Purine Derivatives by one-pot three-component mannich type reaction,Heterocyclics, 2013, 87, 2081-2091.
[30]Jia-jia Jin, Dong-chao Wang, Hong-ying Niu*, Shan Wu, Gui-rong Qu, Zhong-bo Zhang and Hai-Ming Guo*,Br?nsted Acid Catalyzed Synthesis of 1,3-Di(2-quinolyl)propane Derivatives via Tandem C(sp3)-H Functionalization, Tetrahedron, 2013, 69, 6579-6584.
[31] Qian Zhang*, Gang Cheng, Yong-Zhen Huang, Gui-Rong Qu, Hong-Ying Niu, Hai-Ming Guo*, Regioselective N9 alkylation of purine rings assisted by b-cyclodextrin, Tetrahedron, 2012, 68, 7822-7826.
[32] Ran Xia, Hong-Ying Niu, Gui-Rong Qu,* Hai-Ming Guo*, CuI Controlled C-C and C-N Bond Formation of Heteroaromatics through C(sp3)-H Activation, Org. Lett.,2012, 14, 5546–5549.(Highlighted by SYNFACTS, 2013, 2(9), 0197.and Org. Chem. Portal.)
[33] Hong-Ying Niu, Shi-Xia Bai, Shan Wu, Gui-Rong Qu,* Hai-Ming Guo*, Synthesis of Chiral N-(Purin-6-yl)amino Acids Derivatives: Using Natural Amino Acids as Starting Materials, Asian J. Org. Chem., 2012, 1, 238–244.
[34] Gui-Rong Qu, Lei Liang, Hong-Ying Niu, Wei-Hao Rao, Hai-Ming Guo,* John S. Fossey,* Copper-Catalysed Synthesis of Purine-Fused Polycyclics, Org. Lett., 2012,14(17),4494–4497.
[35]. Jin-Ying Liu,Hong-Ying Niu,Shan Wu, Gui-Rong Qu,* Hai-Ming Guo,*Metal Catalyzed C(sp3)-H Bond Amination of 2-Alkyl Azaarenes with Diethyl Azodicarboxylate, Chem. Commun., 2012, 48 (78), 9723-9725.(Top ten most accessed articles in August)
[36]Ge Meng, Hong-Ying Niu, Gui-Rong Qu, John S. Fossey, Jian-Ping Li,* Hai-Ming Guo,* 'Synthesis of Fused N-Heterocycles via Tandem C-H Activation' Chem. Commun.,2012, 48, 9601-9603. (Top ten most accessed articles in July)
[37] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization, Chem. Commun.,2012, 48, 6717-6719. (Highlighted by SYNFACTS, 2012, 8(8), 0901.)
[38] Jia-Jia Jin, Hong-Ying Niu, Gui-Rong Qu, Hai-Ming Guo,* John S. Fossey*, Copper-catalysed addition of a-alkyl azaarenes to ethyl glyoxylate via direct C(sp3)-H activation, RSC Adv., 2012, 2, 5968-5971 .
[39] Gui-Rong Qu,* Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo,* John S. Fossey,Cu(OTf)2-catalyzed Ritter reaction: Efficient synthesis of amides from nitriles and halohydrocarbons in water, RSC Adv., 2012, 2, 6161-6163 . (Highlighted by Chemistry in Water of Organic & Biomolecular Chemistry Blog, 2014-3-20至2014-4-21)
[40]. Gui-Rong Qu,* Hong-Liang Zhang, Hong-Ying Niu, Zai-Kun Xue, Xin-Xin Lv, Hai-Ming Guo*, Synthesis of C6-Azolyl Purine Nucleosides via C-N Coupling Reaction of Unprotected 6-Chloropurine Nucleosides and N-Heterocycles under Catalyst- and Solvent-Free Conditions, Green Chem.,2012, 14, 1877-1879 .
[41] Hong-Ying Niu, Chao Xia, Gui-Rong Qu*, Shan Wu, Yi Jiang, Xin Jin, Hai-Ming Guo*Microwave Promoted One-Pot Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor, Chemistry - An Asian Journal, 2012, 7(1), 45-49.
專(zhuān)利成果： 1. 化學(xué)合成法生產(chǎn)腺苷的工藝，(ZL01127525.1)，授權(quán)時(shí)間2005.1.26；(第6完成人) 2. 化學(xué)合成法生產(chǎn)2,6-二氯嘌呤核苷的工藝，(ZL200710053919.7)，授權(quán)時(shí)間2009.1.26；(第3完成人) 3. 化學(xué)合成法生產(chǎn)胞苷的工藝，(ZL200710053853.1)，授權(quán)時(shí)間2009.5.3。(第5完成人) 4. 具有抗癌活性的6-位被單氮雜冠醚修飾的嘌呤核苷類(lèi)新化合物及制備方法，（ZL 2009 1 0064796.6），授權(quán)時(shí)間2010.12.9，(第1完成人) 5. 5-環(huán)己基阿糖尿苷、制備方法及其應(yīng)用，（ZL201310428434.7），授權(quán)時(shí)間2015.05.27，(第2完成人) 6. 8-環(huán)己基-2-氟阿糖腺苷、制備方法及其應(yīng)用,（ZL201310428421.X），授權(quán)時(shí)間2015.05.27，(第1完成人) |
