姓名：

渠桂榮

職稱：

教授、博士生導師

辦公電話：

0373-3329276

電子郵箱：

[email protected]

個人簡介：

渠桂榮,教授、博士生導師，1976年在本校畢業(yè)后留校任教至今。主講課程有《波譜分析與實驗》、《有機化學》、《綠色化學》、《天然藥物化學》、《現代化學實驗技術》等。現任國家級有機化學教學團隊第一負責人、河南省有機重點學科點第一學術帶頭人，功能有機分子化學與技術河南省高校重點學科開放實驗室主任。兼任河南省化學會常務理事，河南省化學會有機專業(yè)委員會主任。河南省勞動模范、河南省十大女杰、全國模范教師、全國三八紅旗手、享受國務院特殊津貼專家、國家級教學名師獎獲得者。在Chem. Eur. J..，Chem.Comm., Green Chem.,   J.Org.Chem. Org. Lett. 等SCI期刊發(fā)表論文100余篇，被SCI引用1000余次。受理國家發(fā)明專利10項。

研究領域：

1.有機合成
2.核苷類化合物的合成與產業(yè)化
3.天然產物的分離、結構鑒定與合成

主要學術及社會兼職：

現任國家級有機化學教學團隊第一負責人、河南省有機重點學科點第一學術帶頭人，功能有機分子化學與技術河南省高校重點學科開放實驗室主任。兼任河南省化學會常務理事，河南省化學會有機專業(yè)委員會主任。

主持或參加科研項目情況：

1.國家自然科學基金（21172059）: 基于C-H鍵活化的偶聯反應綠色合成熒光修飾的核苷類化合物

2.國家自然科學基金（20772024）：脫氧及核苷的綠色合成研究

3.國家自然科學基金（20372018）：微波技術合成核苷類化合物的新方法研究

4.國家自然科學基金（29972010）：裂葉苣荬菜抗乙型肝炎病毒活性成分的研究

5.河南省杰出人才創(chuàng)新基金（074200510020）核苷類化合物的綠色合成研究
6.河南省重點引智項目，（L20064100009）脫氧核苷的合成及產業(yè)化研究

7.拓新生化科技有限公司橫向項目關于“聯合開發(fā)核苷類化合物”
的技術合作協(xié)議

8.拓新生化科技有限公司橫向項目關于“聯合開發(fā)阿糖核苷類化合物”
的合同

學術成果：

代表性論文：

[1] Gui-Rong Qu,* Hong-Liang Zhang, Hong-Ying Niu, Zai-Kun Xue, Xin-Xin Lv, Hai-Ming Guo*, Synthesis of C6-Azolyl Purine Nucleosides via C-N Coupling Reaction of Unprotected 6-Chloropurine Nucleosides and N-Heterocycles under Catalyst- and Solvent-Free Conditions, Green Chem, 2012, DOI: 10.1039/c0xx00000x.
[2] Gui-Rong Qu,* Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo,* John S. Fossey, Cu(OTf)2-catalyzed Ritter reaction: Efficient synthesis of amides  from nitriles and halohydrocarbons in water, RSC Adv, 2012, DOI:10.1039/C2RA20941A.
[3] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization, Chem. Commun, 2012, DOI:10.1039/C2CC32396F.
[4] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*Nickel-Catalyzed sp2 C-H Bonds Arylation of N-Aromatic Heterocycles with Grignard Reagents at Room Temperature Chem. Commun 2011, 47, 11140-11142.
[5] Hai-Ming Guo*TtengFei-Yuan Hong-Ying Niu, JinYing-Liu , Run-Ze Mao Gui-Rong Qu,* , Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides via Organocatalytic Aza Michael Addition Chem. Eur. J. 2011, 17: 4095–4098
[6] Hai-Ming Guo*Wei-Hao Rao Hong-Ying Niu, Li-Li Jiang ,Ge-Meng,   Jia-Jia Jin Xi-Ning Yang, Gui-Rong Qu,* Palladium-Catalyzed C-H Bond Functionalization of C6-Arylpurines, chemical communications2011, 47,  5608-5610
[7] Gui-Rong Qu,*TtengFei-Yuan Hong-Ying Niu, Xin Jin, Xiao-Ting Guo, Xi-Ning Yang, Hai-Ming Guo* Microwave Promoted Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurines with Sodium Tetraarylborate in Water, Tetrahedron 2011, 47, 9099-9103
[8] Hai-Ming Guo*, Li-Li Jiang , Hong-Ying Niu,Wei-Hao Rao Lei Liang, , Run-Ze Mao ,De-Yang Li, Gui-Rong Qu,*Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C?H Activation: A New Strategy for Modification of 6-Arylpurine   Derivatives, Organic Letters2011, 13(8), 2008–2011
[9] Hong-Ying Niu, Chao Xia, Gui-Rong Qu*, Shan Wu, Yi Jiang, Xin Jin, Hai-Ming Guo*, Microwave Promoted One-Pot Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor, Chem. Asian J., 2012, 7,   45-49.
[10] Jia-Jia Jin, Hong-Ying Niu, Gui-Rong Qu, Hai-Ming Guo,* John S. Fossey*, Copper-catalysed addition of ?-alkyl azaarenes to ethyl glyoxylate via direct C(sp3)-H activation, RSC Adv., 2012, DOI:10.1039/C2RA20627G.
[11] Gui-Rong Qu*, Ran Xia, Xi-Ning Yang, Jian-Guo Li, Dong-Chao Wang, Hai-Ming Guo*
Synthesis of Novel C6-phosphonated Purine Nucleosidis Under Microwave Irradiation by SNAr-Arbuzov Reaction.J.Org.Chem .2008,73,2416-2419
[12] Gui-Rong Qu*, Bo Ren, Hong-Ying Niu, Zhi-Jie Mao, Hai-Ming Guo*A Novel One-step Method for The Synthesis of C-5-substituted O6,5’-Cyclopyrimidine Nucleoside Analogues In Ammonia Water.  J.Org.Chem 2008,73,2450-2453
[13] Gui-Rong Qu*, Lin Zhao, Dong-Chao Wang, Jing Wu, Hai-Ming Guo*Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogues in Neat Water,Green Chem. 2008, 10, 287-289
[14] Gui-Rong Qu*, Zhi-Jie Mao, Hong-Ying Niu, Dong-Chao Wang, Chao Xia, Hai-Ming Guo*,Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate, Org. Lett. 2009, 11 (8), 1745-1748.
[15] Gui-Rong Qu*, Jing Wu, Yan-Yan Wu, Feng Zhang Hai-Ming Guo*,Synthesis of novel 6-[N, N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water, Green Chem., 2009, 11, 760-762.
[16] Hai-Ming Guo*, Peng-Yang Xin, Hong-Ying Niu, Dong-Chao Wang, Yi Jiang, Gui-Rong Qu*,Microwave Irradiated C6-Functionalization of 6-Chloropurine Nucleosides with Various Mild Nucleophiles under Solvent-Free Condition, Green Chem., 2010,  12, 2131-2134.
[17] Hai-Ming Guo*, Pu Li, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Direct Synthesis of 6-Arylpurines by Reaction of 6-Chloropurines with Activated Aromatics, J. Org. Chem,2010, 75, 6016-6018.
[18] Hai-Ming Guo*, Yan-Yan Wu, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction, J. Org. Chem, 2010, 75, 3863-3866.
[19] Hai-Ming Guo,a,* Chao Xia,a Hong-Ying Niu,b Xiao-Ting Zhang,a Si-Nan Kong,a Dong-Chao Wang, and Gui-Rong Qua,* Intermolecular Hydrogen Abstraction Reaction between Nitrogen Radicals in Purine Rings and Alkyl Ethers: A Highly Selective Method for the Synthesis of N-9 Alkylated Purine Nucleoside Derivatives. Adv. Synth. Catal. 2011, 353, 53 – 56
[20] Hai-Ming Guo*, Jing Wu, Hong-Ying Niu, Dong-Chao Wang, Feng Zhang, Gui-Rong Qu*,Synthesis of Novel Fluorescent Purine analogues Modified by Azacrown Ether at C6, Bioorg. Med. Chem. Lett., 2010, 20, 3098-3102.

專利成果：

(1)渠桂榮，董春紅，楊西寧，蔡玉瑛，田鄭剛，郭海明，王秀強
專利名稱：化學合成法生產腺苷的工藝
授權時間：2005.01 授權編號：ZL 01127525.1

(2)渠桂榮，楊西寧，申艷紅，董春紅，郭海明，王秀強，王東超
專利名稱：化學合成法生產胞苷的工藝
授權時間：2009.05 授權編號：ZL200710053853.1

(3)渠桂榮，楊西寧，郭海明，蔡玉瑛，何元慶，王秀強，徐紹紅，李建平
專利名稱：化學合成法生產2，6-二氯嘌呤核苷的工藝
授權時間： 2009.02      授權編號： ZL 200710053919.7
(4)郭海明，渠桂榮，吳靜，王東超，楊西寧，張新迎，牛紅英，夏然，王菲菲，蔡玉瑛，王秀強

專利名稱：具有抗癌活性的6-位被單氮雜冠醚修飾的嘌呤核苷類新化合物及制備方法

授權時間：2010.12 授權編號：No 200910064796.6

獎勵：

(1)渠桂榮等《系列核苷生產新工藝》2007年獲國家科技進步二等獎。

(2)渠桂榮等《化學法生產腺苷的工藝》2006年獲中國發(fā)明專利獎優(yōu)秀獎。
(3)渠桂榮*，趙琳，王東超吳靜，郭海明發(fā)表在Green Chem. 2008,10,295-29上的論文：Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogus In neat Water，2010年獲河南省自然

科學優(yōu)秀論文一等獎。

(4)渠桂榮*，夏然，郭海明，楊西寧，王東超發(fā)表在 J.Org.Chem 2008,73,2416-2419 上的論文：Synthesis of Novel C6-Phosphonated Purine Nucleosides under Microwave Irradiation by SNAr-Arbuzov Reaction  2010年獲河南省自然科學優(yōu)秀論文二等獎。
(5)渠桂榮*，任博，牛紅英 毛志杰，郭海明，發(fā)表在 J.Org.Chem 2008,73,2450-2453 的論文：A Novel One-Step Method for the Synthesis of C-5-substituted O6,5′-cyclopyrimidine Nucleoside Analogues in Ammonia Water 2010年4月，獲得河南省自然科學優(yōu)秀論文獎，二等獎。
(6)渠桂榮，毛志杰，牛紅英，王東超發(fā)表在的論文Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate， 2011年1月，獲得河南省自然科學優(yōu)秀論文獎，一等獎。