孔祥會(huì) 博士 教授 博導(dǎo)
孔祥會(huì),，博士,，二級(jí)教授,，博士生導(dǎo)師,。水產(chǎn)動(dòng)物疾病控制河南省工程實(shí)驗(yàn)室主任,，河南省學(xué)術(shù)技術(shù)帶頭人,，河南省科技創(chuàng)新杰出青年,，河南省高校創(chuàng)新人才,，水產(chǎn)一級(jí)學(xué)科帶頭人，水產(chǎn)博士學(xué)位授權(quán)點(diǎn)帶頭人,，河南省創(chuàng)新型科技團(tuán)隊(duì)帶頭人,。獲河南省先進(jìn)工作者，河南省優(yōu)秀黨員,，河南省職業(yè)道德建設(shè)先進(jìn)個(gè)人,，河南師范大學(xué)首屆校園十大育人楷模等稱號(hào)。現(xiàn)為中國水產(chǎn)學(xué)會(huì)理事,，中國魚類學(xué)會(huì)理事,，河南省水產(chǎn)學(xué)會(huì)秘書長。2004年獲廈門大學(xué)博士學(xué)位,；2007年中科院水生所生物學(xué)博士后流動(dòng)站完成博士后研究,；2009-2010年在美國University of California, Los Angeles (UCLA)留學(xué)。
孔祥會(huì)教授長期以來從事水產(chǎn)動(dòng)物免疫和疾病防控,、免疫組學(xué)解析,、疫苗研發(fā)和藥物創(chuàng)新等研究，并取得重要研究成果,。主持國家自然科學(xué)基金3項(xiàng),主持國家863項(xiàng)目子課題,、河南省科技創(chuàng)新杰出青年計(jì)劃和河南省重點(diǎn)科技攻關(guān)項(xiàng)目等20余項(xiàng)；參與完成國家自然科學(xué)基金重點(diǎn)項(xiàng)目,、國家973項(xiàng)目子課題,、國家“藍(lán)色糧倉”重點(diǎn)專項(xiàng)等。在Aquaculture, Vaccine, Fish Shellfish Immun, J Fish Dis,，中國科學(xué)和科學(xué)通報(bào)等重要學(xué)術(shù)刊物上發(fā)表學(xué)術(shù)論文160余篇,，其中SCI源期刊收錄論文80余篇,。出版學(xué)術(shù)專著3部，授權(quán)國家發(fā)明專利5項(xiàng),，獲河南省科技獎(jiǎng)勵(lì)3項(xiàng),。
▊已取得的創(chuàng)新性成果
孔祥會(huì)教授創(chuàng)新性成果及科學(xué)發(fā)現(xiàn)主要有：（1）采用分子免疫學(xué)、免疫組學(xué)和生物信息學(xué)等技術(shù)方法,，系統(tǒng)研究了病原感染后水產(chǎn)動(dòng)物免疫響應(yīng)模式,、信號(hào)調(diào)控通路及其免疫調(diào)節(jié)機(jī)制。學(xué)術(shù)成果發(fā)表在Aquaculture,、Fish & Shellfish Immunology等期刊發(fā)表,。此外，還分別研究了抗菌肽,、抗氧化酶,、溶菌酶等不同的天然免疫相關(guān)基因及其對(duì)病原體的響應(yīng)。（2）系統(tǒng)研究了水產(chǎn)動(dòng)物重要病原的生物學(xué)和流行病學(xué),，弄清病原與機(jī)體互作,、入侵致病過程及其致病機(jī)制，為疾病防控提供指導(dǎo),。取得的重要學(xué)術(shù)成果已在Aquaculture,、Journal of fish disease等期刊發(fā)表上發(fā)表。（3）水產(chǎn)動(dòng)物疫苗研發(fā)和疫苗導(dǎo)入技術(shù),。針對(duì)重要致病病原,，研究和制備高效的滅活疫苗、弱毒疫苗和亞單位疫苗,。取得的重要成果已在Vaccine,、Fish & Shellfish Immunology等期刊發(fā)表；團(tuán)隊(duì)自行研發(fā)的超聲波和高滲食鹽輔助浸浴法高效疫苗導(dǎo)入技術(shù),，對(duì)小規(guī)格魚種免疫有獨(dú)到優(yōu)勢(shì),，已推廣應(yīng)用2000余畝，獲得較好的經(jīng)濟(jì)效益和生態(tài)效益,。（4）新型綠色漁藥創(chuàng)制,。利用代謝組學(xué)篩選水產(chǎn)動(dòng)物小分子代謝物，作為漁藥增效劑,，以大幅減量漁藥使用,。研發(fā)適用于水產(chǎn)動(dòng)物的中草藥制劑和免疫增加劑，以增強(qiáng)機(jī)體免疫,，預(yù)防疾病的發(fā)生,。
▊代表性科研項(xiàng)目
（1）主持國家自然科學(xué)基金聯(lián)合基金項(xiàng)目（U2004154），項(xiàng)目名稱：嗜水氣單胞菌感染后黃河鯉IL-1β生成和分泌調(diào)控的分子機(jī)制研究，在研,，項(xiàng)目執(zhí)行期：2021-2023,。
（2）主持國家自然科學(xué)基金聯(lián)合基金項(xiàng)目(U1604104),，項(xiàng)目名稱：草魚pIgR受體結(jié)合和轉(zhuǎn)運(yùn)IgM的分子機(jī)制研究,，結(jié)項(xiàng)。
（3）主持國家自然科學(xué)基金項(xiàng)目(30770299),，項(xiàng)目名稱: 尺寸控制基因調(diào)控序列在鯉科魚類中的變異及系統(tǒng)演化,，結(jié)項(xiàng)。
（4）主持河南省科技創(chuàng)新杰出青年計(jì)劃(124100510017),，項(xiàng)目名稱：魚類組蛋白H2B衍生抗菌肽基因變異對(duì)抗菌影響及高活性抗菌肽篩選,，結(jié)項(xiàng)。
（5）主持河南省高?？萍紕?chuàng)新團(tuán)隊(duì)支持計(jì)劃（15IRTSTHN018）,，團(tuán)隊(duì)名稱：水產(chǎn)動(dòng)物醫(yī)學(xué)，結(jié)項(xiàng),。
（6）主持河南省高?？萍紕?chuàng)新人才支持計(jì)劃(2011HASTIT012)，項(xiàng)目名稱：魚類低氧誘導(dǎo)因子HIF-1α分子進(jìn)化和基因改造及作用研究,，結(jié)項(xiàng),。
▊代表性學(xué)術(shù)論文
孔祥會(huì)近5年以第一作者或通訊作者發(fā)表的代表性論文：
【1】Yuan Gaoliang#, Zhu Lei#, Jiang Xinyu, Zhang Jie, Pei Chao, Zhao Xianliang, Li Li, Kong Xianghui*. Diagnosis of co-infection with white spot syndrome virus and Aeromonas veronii in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,532: 736010.
【2】Zhu Lei#, Yuan Gaoliang#, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization of Rab5 and Rab6, and their involvement in innate immunity in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,533: 736085.
【3】Zhu Lei, Gao Yuanyuan, Yuan Gaoliang, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Identification and immune functional analysis of a novel C1q domain-containing protein in Yellow River Carp (Cyprinus carpio L.). Aquaculture, 2021,534: 736313.
【4】Wang Li, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization and biological function of a tandem-repeat galectin-9 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2020,103: 366-376.
【5】Wu Limin, Li Yongjing, Xu Yufeng, Wang Lei, Ma Xiao, Dong Chuanju, Zhao Xianliang, TianXue, Li Xuejun*, Kong Xianghui*. The roles of two myostatins and immune effects after inhibition in Qi river crucian carp (Carassius auratus). Fish & Shellfish Immunology, 2020, 98: 710-719.
【6】Zhao Xian-liang, Wu Gan, Chen He, Li Li, Kong Xiang-hui*. Analysis of virulence and immunogenic factors in Aeromonas hydrophila: Towards the development of live vaccines. Journal of Fish Disease, 2020,43:747-755.
【7】Zhang Jie, Zhu Yachen, Chen Zhuo, Li Chunjing, Zhao Xianliang, Kong Xianghui*. Molecular cloning and expression analysis of MyD88 and TRAF6 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2019, 87: 829-838.
【8】Gao Yan, Pei Chao, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Novel subunit vaccine based on grass carp reovirus VP35 protein provides protective immunity against grass carp hemorrhagic disease. Fish and Shellfish Immunology, 2018, 75:91-98.
【9】Zhao Xianliang, Chen He, Jin Zhaohui, Li Li, Zhang Jie, Kong Xianghui*. GC-MS-based metabolomics analysis reveals L‐aspartate enhances the antibiotic sensitivity of neomycin sulfate-resistant Aeromonas hydrophila. Journal of fish diseases, 2018, 41(12): 1831-1841.
【10】Gao Yan #, Pei Chao #, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Plasmid pcDNA3.1-s11 constructed based on the S11 segment of grass carp reovirus as DNA vaccine provides immune protection. Vaccine, 2018, 36:3613-3621.
【11】Kong Xianghui*, Wang Li, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li. Comparison of polymeric immunoglobulin receptor between fish and mammals. Veterinary Immunology and Immunopathology, 2018,202: 63-69.
【12】Zhao Xianliang, Chen He, Zhong Keke, Li Li, Kong Xianghui*. Myo-inositol as an adjuvant to florfenicol against Aeromonas hydrophila infection in common carp Cyprinus carpio. FEMS Microbiology Letters, 2018, 365(20): fny212.
【13】Zhang Jie, Wang Li, Zhao Yanjing, Kong Xianghui*, Wu Fan, Zhao Xianliang. Molecular characterization and expression analysis of toll-like receptors 5 and 22 from natural triploid Carassius auratus.Fish and Shellfish Immunology,2017,64:1-13.
【14】Kong Xianghui*, Wu Xiangmin, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li, Nie Guoxing, Li Xuejun. H2A and Ca-L-hipposin gene: Characteristic analysis and expression responses to Aeromonas hydrophila infection in Carassius aurutus. Fish and Shellfish Immunology, 2017,63: 344-352.
【15】Di Guilan, Li Hui, Zhang Chao, Zhao Yanjing, Zhou Chuanjiang, Naeem Sajid, Li Li, Kong Xianghui*. Label-free proteomic analysis of intestinal mucosa proteins in common carp (Cyprinus carpio) infected with Aeromonas hydrophila. Fish and Shellfish Immunology, 2017, 66: 11-25.
【16】Wang Li, Zhang Jie, Kong Xianghui*, Zhao Xianliang, Pei Chao, Li Li. A C-type lectin, Nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: Binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria. Fish and Shellfish Immunology, 2017, 67: 382-392.
【17】Kong Xianghui*, Qiao Dan, Zhao Xianliang, Wang Li, Zhang Jie, Liu Dandan , Zhang Hongxu. The molecular characterizations of Cu/ZnSOD and MnSOD and its responses of mRNA expression and enzyme activity to Aeromonas hydrophila or lipopolysaccharide challenge in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2017, 67: 429-440.
【18】Wang Li, Zhang Jie, Kong Xianghui*, Pei Chao, Zhao Xianliang, Li Li. Molecular characterization of polymeric immunoglobulin receptor and expression response to Aeromonas hydrophila challenge in Carassius auratus. Fish and Shellfish Immunology, 2017, 70: 372-380.
【19】Zhao Yanjing, Jiang Xinyu, Kong Xianghui*, Di Guilan, Nie Guoxing，Li Xuejun. Effects of hypoxia on lysozyme activity and antioxidant defences in the kidney and spleen of Carassius auratus. Aquaculture Research, 2017, 48: 223-235.
【20】Wang Meijuan, Zhao Xianliang, Kong Xianghui*, Wang Li, Jiao Dan, Zhang Hongxu. Molecular characterization and expressing analysis of the c-type and g-type lysozymes in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2016, 52: 210-220.
【21】Jiang Xinyu, Zhang Chao, Zhao Yanjing, Kong Xianghui*,Pei Chao, Li Li, Nie Guoxing, Li Xuejun. Immune effects of the vaccine for live attenuated Aeromonas hydrophila screened using rifampicin on common carp (Cyprinus carpio L.). Vaccine, 2016, 34(27):3087-3092.
【22】Zhang Jie, Chen Zhuo, Zhou Chuanjiang, Kong Xianghui*. Molecular phylogeny of the subfamily Schizothoracinae (Teleostei: Cypriniformes: Cyprinidae) inferred from complete mitochondrial genomes. Biochemical Systematics and Ecology, 2016,64: 6-13.
【23】Jiang Hongxia, Kong Xianghui*, Wang Shuping, Guo Huiyun. Effect of copper on growth, digestive and antioxidant enzyme activities of juvenile Qihe crucian carp during exposure and recovery. Bulletin of Environmental Contamination and Toxicology, 2016, 96:333-340.
【24】趙燕靜,，狄桂蘭,，孔祥會(huì)*，張杰,，李莉,，聶國興，李學(xué)軍. 低氧環(huán)境下poly I:C刺激對(duì)淇河鯽肝胰臟抗氧化防護(hù)的影響,，水產(chǎn)學(xué)報(bào),，2016, 40: 1830-1841.
▊科研團(tuán)隊(duì)理念
做一流學(xué)問，樹一流人品,，育一流人才
▊研究生招生和博士后入站
碩士生招生：水產(chǎn)一級(jí)碩士點(diǎn)
學(xué)術(shù)型碩士：水產(chǎn)動(dòng)物醫(yī)學(xué)方向,；
專業(yè)型碩士：水產(chǎn)動(dòng)物疾病防控方向。
博士生招生：水產(chǎn)一級(jí)博士點(diǎn)
招生方向：水產(chǎn)動(dòng)物醫(yī)學(xué)（水產(chǎn)動(dòng)物免疫和疾病防控）,；
博士后入站：生物學(xué)博士后流動(dòng)站常年招收博士后
▊聯(lián)系方式
河南省新鄉(xiāng)市建設(shè)路46號(hào),，河南師范大學(xué)水產(chǎn)學(xué)院，郵編：453007
電子郵件：[email protected]；[email protected]
歡迎有志之士加盟我們的科研團(tuán)隊(duì),，走進(jìn)科學(xué)殿堂,，探索科學(xué)奧秘。
