白大昌 博士,，副教授,，博士生導(dǎo)師

        本科畢業(yè)于鄭州大學(xué)化學(xué)系,，博士畢業(yè)于中國科學(xué)院上海有機(jī)化學(xué)研究所,，獲2020年“Thieme Chemistry Journal Award”國際學(xué)術(shù)期刊獎(jiǎng)，獲河南省第十五屆青年科技獎(jiǎng),，并獲“河南省優(yōu)秀青年科技專家稱號”，2020年 河南省優(yōu)秀青年基金,，郵箱地址：[email protected]; [email protected]

教育經(jīng)歷：

2005.09 - 2009.07: 鄭州大學(xué),，化學(xué)專業(yè)，理學(xué)學(xué)士

2009.09 - 2014.07: 中國科學(xué)院上海有機(jī)化學(xué)研究所,，有機(jī)化學(xué)專業(yè),，理學(xué)博士（碩博連讀），導(dǎo)師：侯雪龍 研究員

工作經(jīng)歷：

2014.07 - 2015.08: 中科院上海有機(jī)所金屬有機(jī)國家重點(diǎn)實(shí)驗(yàn)室,，助理研究員

2015.10–2016.10: 美國內(nèi)布拉斯加醫(yī)學(xué)研究中心,，博士后

2016.11-2020.04：河南師范大學(xué)，講師

2020.04-至今：河南師范大學(xué),，副教授

研究興趣和領(lǐng)域：

1,，發(fā)展以綠色合成化學(xué)為導(dǎo)向的新反應(yīng)方法和技術(shù)，研究過渡金屬催化碳碳鍵活化以及手性氟化合物的合成新方法,。

2,，研究具有潛在生物活性分子的合成。

近年來主持的主要科研項(xiàng)目:

1,， 國家自然科學(xué)基金-青年項(xiàng)目,，銅催化肟酯與缺電子烯烴的環(huán)加成反應(yīng)，2019-2021,， 26萬

2,， 河南省優(yōu)秀青年科學(xué)基金，過渡金屬催化不對稱C-C/C-O 鍵活化反應(yīng)研,，2020-2023,，25萬

3，國家自然科學(xué)基金-面上項(xiàng)目,，2025.1-2028.12,， 50萬

獲獎(jiǎng)情況：

2020年，“Thieme Chemistry Journal Award”國際學(xué)術(shù)期刊獎(jiǎng)

2024年,，獲河南省第十五屆青年科技獎(jiǎng),，并獲“河南省優(yōu)秀青年科技專家稱號”

代表性論文：

(31). Wu, Hao.; Wang, Yiyao.; Sui, Shiyuan.; Chen, Gongming.; Wang, Lei.; Yang, Jiaxin.; Chang, Junbiao.;* Bai, Dachang*Enantioselective Desymmetrization and Parallel Kinetic Resolution of Cyclopropanes via C–C Activation: Synthesis of Chiral β-Lactams.Chem, 2024, 10, 3503-3516.

(30). Bai, Dachang.;* Zhong, Kangbao.; Chang, Lingna.; Qiao, Yan.; Wu, Fen.; Xu, Guiqing.; Chang, Junbiao.* Nickel-catalyzed regiodivergent hydrosilylation of α-(fluoroalkyl)styrenes without defluorination.Nat. Commun. 2024, 15, 6360.

(29). Bai, Dachang.;* Guo, Xiuli.; Wang, Xinghua.; Xu, Wenjie.; Cheng, Ruoshi. Wei, Donghui.; Lan, Yu.; Chang, Junbiao.* Umpolung reactivity of strained C–C σ-bonds without transition-metal catalysis. Nat. Commun. 2024, 15, 2833.

(28).Bai, Dachang.*; Wu, Fen.; Chang, Lingna.;Wang, Manman.; Wu, Hao.; Chang, Junbiao.* Highly Regio- and Enantioselective Hydrosilylation of gem-Difluoroalkenes by Nickel Catalysis. Angew. Chem. Int. Ed.  2022, 61, e202114918.  (Highlight by Synfacts 2022, 18, 0398)

(27). Bai, Dachang.*; Yu, Yanjiang.; Guo, Haiming.; Chang, Junbiao.; Li, Xingwei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and a,b-Unsaturated Ketones/Imines. Angew. Chem. Int. Ed.  2020, 59, 2740-2744. (Highlight by Synfacts 2020.16.641)

(26). Bai, Dachang.; Wang, Xueli.; Zheng, Guangfan.; Li, Xingwei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates. Angew. Chem. Int. Ed. 2018, 57, 6633-6637. 

(25) Wu, Fen.; Chang, Junbiao.; Bai Dachang*. Synthesis of Sterically Hindered Dialkyl Ethers via Palladium-Catalyzed Fluoro-alkoxylation of gem-Difluoroalkenes.Org. Lett.2024, 26, 4953?4957.

(24). Wu, Fen.; Li, Xin.; Chang, Junbiao.; Bai, Dachang.* Palladium-catalyzed multi components oxy-aminofluorination and aminofluorination of gem-difluoroalkenes. Chin Chem Lett.2024, 35, 109155.

(23). Bai, Dachang.;* Li, Xin.; Wu. Fen.; Chang, Junbiao.* Stereoselective hydrodefluorination of CF3-substituted alkenes and gem-difluoroalkenes by H^?.Org. Chem. Front.,2024,11, 1388–1394.

(22). Tiantian Yin, Shiyuan Sui, Shuqi Li, Junbiao Chang*, Dachang Bai.* Nickel-catalyzed stereospecific reductive cross coupling of vinyl chlorosilanes with axially chiral biaryl electrophiles. Chem. Commun.,2024, 60, 14204.

(21). Tiantian Yin, Ming Jin, Tiantian Zhao, Junbiao Chang,* Dachang Bai*. Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes.Org. Lett. 2024, 26, 8194?8199

(20). Ma, Dandan.; Chang, lingna.; Cai, Yue; Bai, Dachang.* Visible-Light-Induced Photoredox Construction of Trifluoromethylated Quaternary All-Carbon Centers and Tertiary Alcohols via C(sp3)–Si Bond Cleavage. Synthesis 2024, DOI: 10.1055/s-0040-1720139.

(19). Wang, Manman.; Xi, Wenhui.; Wu, Hao.; Bai, Dachang.* Recent Advances in Transition-metal Catalyzed C–H bond Activation for the Synthesis of C(sp³)-fluoroalkyl Compounds. Chin. J. Org. Chem. 2024, DOI: 10.6023/cjoc202406033

(18). Wu, Hao.; Liu, Zhen.; Bai, Dachang.*¹H NMR Spectrum of Amide Compounds.Univ. Chem. 2024, 39, 231.

(17). Bai, Da-Chang.*; Guo, Yuanyuan.; Ma, Dandan.; Guo, Xiuli.; Wu, Hao. Copper-Catalyzed Hydroamination of gem-Difluoroalkenes Access to Diversified α?Difluoromethyl Amines. Org. Lett. 2023, 25, 533-537.

(16).Chen, Junyan.; Bai, Dachang.;^* Guo, Xiuli.; Wang, Yiyao.;Li, Xingwei.* Diastereodivergent [4+2] Annulation of Biphenylenes with Enones via Nickel(0)-catalyzed C-C bond Activation. Chin Chem Lett. 2022. 33, 5056-5060.

(15). Bai, Dachang.;*  Liu, Song.; Chen, Junyan.; Yu, Yanjiang.; Wang, Manman.; Chang, Junbiao.; Lan., Yu.;* Li, Xingwei.* Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis via C–C activation of diarylcyclopropenones.Org. Chem. Front., 2021, 8, 3023-3031.

(14). Bai, Dachang.;* Chen, Junyan.; Zheng, Bingbing.;  Li, Xueyan.; Chang, Junbiao*. Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenones via C(sp3)-O/C-C Bond Cleavage under Transition-Metal Free Conditions. Chin. J. Chem. 2021, 39, 2769-2773.

(13). Xu, Guiqing.; Chen, Qi.; Wu, Fen.; Bai, Dachang.;* Chang, Junbiao.;* Li, Xingwei.* Rh(III)-Catalyzed Chemodivergent Coupling of N?Phenoxyacetamides and Alkylidenecyclopropanes via C?H Activation.Org. Lett. 2021, 23, 2927?2932.

(12). Cheng, Ruoshi.; Bai, Dachang.* Enantiodivergent Relay Coupling for Nickel-Catalyzed Stereoselective Functionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem. 2021, 41, 1746-1748.

(11). Cui, Yixin.; Bai, Dachang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation. Chem. Commun., 2020, 56, 15631-15634.

(10). Li, Xue-yan.; Yu, Yanjiang.; Qi, Ruobing.; Bai, Dachang*. Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile. Tetrahedron Lett. 2020. 61, 151858-151861. 

(9). Dai, Hongxue.; Wu, Fen.; Bai, Dachang*. Recent Advances in Ni-Catalyzed C-C bond Activation Reactions. Chin. J. Org. Chem. 2020. 40. 1423-1436.

(8). Bai, Dachang. ^(#); Xia, Jintao. ^(#); Song, Fangfang .; Li, Xueyan.; Liu, Bingxian.; Liu, Lihong.; Zheng, Guangfan.; Yang, Xifa.; Sun, Jiaqiong, * Li, Xingwei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp³/sp² C–H activation and 1,4-rhodium migration. Chem. Sci. 2019, 10. 3987-3993. (#: co-first authors)

(7) Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue, Bai Dachang.* Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates. Chin. J. Org. Chem., 2019, 39, 1623-1629.

(6).Bai, Dachang.*;Xu, Teng.; Ma, Chaorui.; Zheng, Xin.; Liu, Bingxian.; Xie, Fang.; Li, Xingwei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C?H Activation: Facile Access to Bridged Cycles.  ACS Catal. 2018, 8, 4194-4200.  

(5). Yu, Feile.^(#); Bai, Dachang.^(#) ; Liu, Xiuyan.^(#); Jiang, Yangjie.; Ding, Changhua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers. ACS Catal. 2018, 8, 3317–3321.(#: co-first authors)

(4) Bai. Dachang.; Jia, Qingqian.; Xu, Teng.; Zhang, Qiuqiu.; Wu, Fen.; Ma, Chaorui.; Liu, Bingxian.; Chang, Junbiao.; * Li, Xingwei.* Rhodium(III)-Catalyzed C–H Activation of Nitrones and Annulative Coupling with Nitroalkenes. J. Org. Chem. 2017, 82, 9877–9884.

(3) Bai. Da-chang.; Liu, Xiu-Yan.; Li, Hao.; Ding, Changhua.;* Hou. Xue-Long.* Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity.Chem. Asian J. 2017, 12, 212–215.

Before HTU

(2) Bai, Da-chang.; Yu, Feile.; Wang, Wanying.; Chen, Di.; Li, Hao.; Liu, Qingrong.; Ding, Changhua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism. Nat. Commun.  2016, 7, 11806–11817. 

(1) Bai, Da-chang.; Wang, Wanying.; Ding, Changhua.; Hou, Xue-Long.* Kinetic Resolution of Unsymmetrical Acyclic Allyl Carbonates Using Trimethylsilyl Cyanide via Palladium-Catalyzed Asymmetric Allylic Alkylation. Synlett2015, 26, 1510–1514.