個(gè)人簡(jiǎn)介模板

個(gè)人簡(jiǎn)介：楊守寧,，男，博士,，副教授,，博士生導(dǎo)師。E-mail: [email protected]

學(xué)習(xí)經(jīng)歷：
 2015.06    華東師范大學(xué)化學(xué)系,，有機(jī)化學(xué)專業(yè),，理學(xué)博士,；

工作經(jīng)歷：

2007.07-2011.09，上海清松制藥有限公司,，高級(jí)研究員,；

2016.至今，河南師范大學(xué) 副教授,，博導(dǎo),；

研究領(lǐng)域與興趣：

1．新型抗菌、抗癌藥物的開發(fā)

2. 功能型納米材料的設(shè)計(jì)合成及生物學(xué)應(yīng)用研究

在研項(xiàng)目：

1.國家自然科學(xué)基金-面上項(xiàng)目  82073699  一種雙酰肼基肽脫甲?；敢种苿┑脑O(shè)計(jì)合成及活性研究     主持

2.國家自然科學(xué)基金-河南省聯(lián)合項(xiàng)目 U1904196  基于惡性腫瘤光熱/光動(dòng)力/免疫協(xié)同治療的鉍基納米復(fù)合材料的構(gòu)筑,、構(gòu)效關(guān)系與機(jī)制研究  第二參與人     

3.河南省科技攻關(guān)項(xiàng)目 172102310618 基于肽脫甲酰基酶為靶點(diǎn)的新型抗生素的設(shè)計(jì)合成與活性研究     主持

4. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目 19A350004 金屬蛋白酶抑制劑關(guān)鍵中間體的合成方法研究    主持

代表性論文：

1.Yang, Shouning; Wang, Yaru; Yang, Yujie; Zhang, Zhiqin; Li, Fengfeng; Tao, Lingling; Han, Ling; Guo, Shenghai; Zhang, Ying; Jiang, Yuqin; Chang, Junbiao; Yang, Huayan;

 Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive 

 and -Negative Bacteria, Journal of Medicinal Chemistry, 2025, 68(3)：2942-2962. (SCI, IF：7.3)

2.Shouning Yang, Xiaoyang Liu, Shengkun Wang, Jian Song, Jichun Wu, Baoxing Shen, Hongyan Jia1, Shenghai Guo, Yaru Wang, Yujie Yang, Yuqin Jiang, Huayan Yang*, Junbiao Chang*.

 Chalcone Derivatives as Dual-sensitive Fluorescent Probe for Protein Aggregation Investigation. Sensors and Actuators B: Chemical 2023, 395, 134514. (SCI, IF：8.4)

3.Shouning Yang, Shengkun Wang, Yaru Wanga, Jian Song, Yuqin Jiang, Liang Chen*, Huayan Yang*. Ultrathin Two-Dimensional BiOCl-Bi2S3-Cu2S Ternary Heterostructures with Enhanced 

LSPR effect for NIR Photonic Bacterial Disinfection. Chemistry - A European Journal. 2023, e202203831. (SCI, IF：5.02)

4.Shouning Yang, Shengkun Wang, Yanmin Zhang, Yijing Wang, Jinhong Yuan, Yuqin Jiang, Xing He, Lihong Liu, Jian Song, Liang Chen*, Huayan Yang*. Heterojunction structured BiOCl-Bi2S3

 nanosheets as mitochondria-targeted near-infrared photothermal and photodynamic therapy agent. Colloids and Surfaces B: Biointerfaces. 2023, 222, 113106. (SCI, IF：5.99)

5.Shouning Yang, Qiaoling Zhang, Huayan Yang, Haimei Shi, Aichun Dong, Li Wang*, Shaoning Yu*. Progress in infrared spectroscopy as an efficient tool for predicting protein secondary structure.

 International Journal of Biological Macromolecules. 2022, 206, 175-187（SCI, IF：8.025）

6.Chunhua Ma, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*.

 Discovery of 1-amino-1h-imidazole-5-carboxamide derivatives as highly selective, covalent Bruton’s Tyrosine Kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2021, 64(21), 16242-16270. 

(SCI, IF：8.03)

7.Dandan Zhang, Guiqing Xu, Jie Zhao, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for 

imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724(1-23). (SCI, IF：7.08)

8.Shouning Yang, Xiaoyang Liu, Sijia Lu, Zhuo Li, Yanmin Zhang, Shaoning Yu, Jian Song, Chuanfan Ding, and Huayan Yang. Novel Facile One-Pot Synthesis of Bi2S3-BiOCl Ultrathin Hetero-nanosheets for 

Selective Alcohol Oxidation. ChemCatChem. 2021, 13, 2293 -2302. (SCI, IF：5.49)

9.Huayan Yang, Sijia Lu, Shengkun Wang, Lihong Liu, Bo Zhu, Shaoning Yu, Shouning Yang* and Junbiao Chang*. Evolution of the protein corona affects macrophage polarization. 

International Journal of Biological Macromolecules. 2021, 191,192-200. (SCI, IF：8.02)

10.Shouning Yang, Yanmin Zhang, Sijia Lu, Lin Yang, Shaoning Yu, and Huayan Yang. CaCO3‐Encapsulated Au Nanoparticles Modulate Macrophages toward M1-like Phenotype.

 ACS Applied Bio Mater. 2021, 4, 3214-3223.

11.Shouning Yang, Yuyan Xue, Yanmin Zhang, Sijia Lu, Junli Wu, Lin Yang, Huayan Yang*, and Shaoning Yu*. Mitochondrial Targeting Strategy for Enhanced Photothermal Cancer Therapy.

 ChemNanoMat, 2021, 7, 1–11. (SCI, IF：3.83)

12.Shouning Yang, Yanmin Zhang, Sijia Lu, Lihong Liu, Lin Yang, Yuming Guo, Shaoning Yu, and Huayan Yang*. Labeled-protein corona-coated Bi2S3 nanorods targeted to lysosomes for bioimaging and efficient

 photothermal cancer therapy. Colloids and Surfaces B: Biointerfaces. 2020, 196, 111291. (SCI, IF：5.99)

13.Shouning Yang*, Yanmin Zhang, Yuyan Xue, Sijia Lu, Huayan Yang, Chuanfan Ding, Shaoning Yu*. Cross-linked Polyamide Chains Enhanced the Fluorescence of Polymer Carbon Dots.

 ACS Omega. 2020, 5(14), 8219-8229. (SCI, IF：4.13)

14.Huayan Yang, Yanmin Zhang, Jian Song, Meng Wang, Shaoning Yu, Liang Chen, Xiaomin Li, Shouning Yang*, Lin Yang*. Boosting Phototherapeutic Efficiency with Single NIR Laser-Activated Ultrasmall Bismuth Sulfide

 Quantum Dots. Chemical Engineering Journal. 2019. 375: 121941. (SCI, IF：16.27)

15.Huayan Yang, Meng Wang, Yanmin Zhang, Xiaoyang Liu, Shaoning Yu, Yuming Guo, Shouning Yang*, Lin Yang*. Detailed insight into the formation of protein corona:

 Conformational change, stability and aggregation. International Journal of Biological Macromolecules, 2019. 135: 1114-1122. (SCI, IF：8.02)

16.Huayan Yang, Meng Wang, Yanmin Zhang, Feng Li, Shaoning Yu, Lin Zhu, Yuming Guo, Lin Yang*, Shouning Yang*. Conformational-transited protein corona regulated cell-membrane penetration and induced 

cytotoxicity of ultrasmall Au nanoparticle. RSC Advances, 2019. 9(8): 4435-4444. (SCI, IF：4.04)

17.Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao, Fengping Lv, Liping Yang, Yushe Yang, Wenhao Hu*. Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel 

potent peptide deformylase inhibitors against drug-resistant bacteria. European Journal of Medicinal Chemistry, 2014, 86: 133-152. (SCI, IF：7.08).

18.Huayan Yang, Shouning Yang, Jilie Kong, Aichun Dong*, Shaoning Yu*. Obtaining information about protein secondary structures in aqueous solution using Fourier transform IR spectroscopy.

 Nature Protocols, 2015, 10: 382-396. (SCI, IF：17.02).