個人簡介：馬春華,，男，博士，副教授,，河南省高?？萍紕?chuàng)新人才,，中國化學(xué)會會員。E-mail: [email protected]
教育經(jīng)歷：
2004.09-2008.06 山東大學(xué)藥學(xué)院,，藥學(xué)專業(yè),，理學(xué)學(xué)士,；
2008.09-2013.12 山東大學(xué)藥學(xué)院，藥物化學(xué)專業(yè),，理學(xué)博士,；
工作經(jīng)歷：
2013.12-2015.12，復(fù)旦大學(xué)藥學(xué)院,，藥物化學(xué)專業(yè),，博士后；
2016.03-至今,，河南師范大學(xué)化學(xué)化工學(xué)院講師,。
研究領(lǐng)域與興趣：
1,、小分子抗腫瘤藥物的設(shè)計合成
2、基于靶點的先導(dǎo)化合物的設(shè)計和結(jié)構(gòu)優(yōu)化
1,、國家自然科學(xué)基金青年基金：基于腺嘌呤替代物的雙底物SAHH抑制劑的設(shè)計,、合成及活性研究，項目批準(zhǔn)號：82003585, 2021.01-2023. 12, 24萬元
2,、河南省高?？萍紕?chuàng)新人才：基于腺嘌呤替代物的nsp14 N7-Mtase抑制劑的設(shè)計、合成及抗新冠活性研究,，項目批準(zhǔn)號：24HASTIT069,，2024.01-2026.12，30萬元
3,、河南省自然科學(xué)基金：小分子神經(jīng)生長因子模擬物的設(shè)計,、合成及作用機制研究，項目編號：162300410182, 2017.1-2018.12, 10萬元
4,、河南省高等學(xué)校重點科研項目基礎(chǔ)研究計劃：小分子NGF模擬物的設(shè)計,、合成及應(yīng)用研究，項目編號：17A350008, 2017.1-2018.12,，3萬元
5,、高端外國專家項目：I類新藥布魯頓酪氨酸激酶抑制劑（BTK inhibitor HB040）的研究與開發(fā)，項目編號：GDW20186300346, 30萬元
6,、企業(yè)橫向：新型BTK抑制劑的研究與開發(fā),，合同編號：XH2019059，50萬元
代表性論文：
25) Chunhua Ma*, Qing Guo, Hui Meng, Shengnan Yan, Qingjie Ding, Yuqin Jiang*, Bin Yu *, Photoredox-catalyzed carbamoyl radical-initiated dearomative spirocyclization to access spiro-cyclohexadiene oxindoles. Organic Letters, 2024, 26, 8503-8508.
24）Chunhua Ma*, Mengjiao Liu, Siyu Ouyang, Zhenwei Cui, Jingjing Bi, Yuqin Jiang*, Zhiguo Zhang*, Metal-free construction of diverse 1,2,4-triazolo[1,5-a]pyridines on water. Chinese Chemical Letters, 2025, 36, 109755.
23）Yinghui Huang (本科生), Linhui Shen (本科生), Chunhua Ma*, Yuqin Jiang,* Bing Yu*, Functionalization of 1,3-butadiene derivatives under photo/electrocatalysis. European Journal of Organic Chemistry, 2024, 27, e202400403.
22）Jingyi Liu(本科生), Zhenwei Cui, Jingjing Bi, Xing He, Qingjie Ding*, Hong Zhu*, Chunhua Ma*, Photocatalytic fluoroalkylation by ligand-to-metal charge transfer. Frontiers in Chemistry, 2024, 12, 1481342.
21）Guiqing Xu, Jiayuan Lv, Qingjie Ding, Chunhua Ma,* Yuqin Jiang,* Bin Yu,* Direct C–H alkylation of benzothiadiazoles via organic photoredox catalysis. The Journal of Organic Chemistry, 2024, 89 (4), 2777-2781.
20) Chunhua Ma, Xiaofeng Li, Xiya Chen, Xing He, Shu-Ting Zhang,* Yu-Qin Jiang,* and Bing Yu*, Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives. Organic Letters, 2023, 25, 44, 8016-8021.
19) Chunhua Ma, Yu Tian, Junyan Wang, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Driven Transition-Metal-Free Site-Selective Access to Isonicotinamides.Organic Letters, 2022, 24, 8265-8270.
18) Danfeng Wang (本科生), Jin Wang, Chunhua Ma,* Yuqin Jiang,* Bing Yu*, C-3 functionalization of 2-aryl-2H-indazoles under photo/electrocatalysis. Chinese Journal of Organic Chemistry, 2022, 42, 4024-4036.
17) Jin Wang, Qingyuan Song, Xing He, Chunhua Ma,* Yuqin Jiang,* and Jing Fan,* Visible light-promoted, photocatalyst-free decarboxylative alkylation of 2H-indazoles via electron donor-acceptor complex activation. New Journal of Chemistry, 2022, 46, 16436-16439.
16) Chunhua Ma, Hui Meng, Jing Li, Xianguang Yang, Yuqin Jiang*, Bing Yu*, Photocatalytic Transition-Metal-Free Direct 3-Acetalation of Quinoxaline-2(1H)-ones, Chinese Journal of Chemistry, 2022, 40, 2655-2662.
15) Chunhua Ma, Yue Wang, Guang Chen, Jingyi Li, Yuqin Jiang, Xinying Zhang,* and Xuesen Fan*. Divergent construction of 3-(indol-2-yl)succinimide/maleimide and fused benzodiazepine skeletons from 2-(1H-indol-1-yl)anilines and maleimides. Organic Chemistry Frontiers, 2022, 9, 4663-4669.
14) Chunhua Ma, Hui Meng, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Construction of 3-Perfluoroalkylated Thioflavones, Frontiers in Chemistry, 2022, 10, 953978.
13) Chunhua Ma, Lu Zhao, Xing He, Yuqin Jiang,* and Bing Yu*, Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water, Organic Chemistry Frontiers, 2022, 9, 1445-1450.
12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors. Journal of Medicinal Chemistry, 2021, 64, 16242?16270.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2022, 43, 571-583.
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724.
9) Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers, 2021, 8, 3286-3291.
8）Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.
6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides, Organic Letter 2019, 21(17), 7179-7183.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters2013, 23 (17), 4948-4952.
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
獲得榮譽與獎勵：
河南師范大學(xué)優(yōu)秀教師
Individual profile：Chunhua Ma,，Male,，Ph D，lecturer,，Membership of China Chemical Society.E-mail: [email protected]
Education experience：
2004.09-2008.06 School of pharmaceutical sciences Shandong University, Pharmacology, Bachelor of Science;
2008.09-2013.12 School of pharmaceutical sciences Shandong University,Medicinal chemistry, Doctor of Medicine.
Work experience：
2013.12-2015.12, School of Pharmacy Fudan University, Medicinal chemistry, Post doctor;
2016.03-until now, School of Chemistry and Chemical Engineering, Henan Normal University, Lecturer.
Research Interest：
1、The design and synthesis of small molecular compounds with antitumor activity
2,、Target-based design and structure optimization of lead compounds
近年來主持的主要科研項目:
1,、Henan Natural Science Foundation：The design, synthesis and mechanism of small molecular never growth factor mimics, Project number：162300410182, 2017.1-2018.12, 0.1Million
2、Basic Research Plan of Key Scientific Research Projects in Henan Higher Education Institutions：The design, synthesis and application of small molecular never growth factor mimics, Project number：17A350008, 2017.1-2018.12,，0.03 Million
3,、High-end Foreign Expert Project：Research and Development of Bruton Tyrosine Kinase Inhibitor (BTK inhibitor HB040), Project number：GDW20186300346，3 Million
代表性論文：
12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors. Journal of Medicinal Chemistry, 2021,64, 16242?16270..
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2021, DOI: 10.1016/S1872-2067(21)63917-7
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724.
9）Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers, 2021, DOI: 10.1039/D1QO00064K.
8）Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.
6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides, Organic Letter 2019, 21(17), 7179-7183.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
獲得榮譽與獎勵：
Excellent Teachers of Henan Normal University